Amy Timmons,
Mark Seierstad,
Rich Apodaca,
Matt Epperson, Dan Pippel,
Sean Brown,
Leon Chang,
Brian Scott,
Michael Webb,
Sandra R Chaplan,
J Guy Breitenbucher
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ABSTRACT: Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Bioorganic & medicinal chemistry letters 04/2008; 18(6):2109-13. · 2.65 Impact Factor
