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ABSTRACT: Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Bioorganic & medicinal chemistry letters 04/2008; 18(6):2109-13. DOI:10.1016/j.bmcl.2008.01.091 · 2.42 Impact Factor