Publications (2)5.64 Total impact
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Article: Synthesis and antioxidant properties of pulvinic acids analogues.
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ABSTRACT: The synthesis of three types of pulvinic acid analogues, using a diversity-oriented strategy starting from a single compound, dimethyl l-tartrate, is described. Lacey-Dieckmann condensation, alcohol dehydration and Suzuki-Miyaura cross-couplings were employed in the course of the analogues syntheses. The evaluation of the antioxidant properties of the 28 synthesized analogues was carried out using antioxidant capacity assays (protection of thymidine and β-carotene) and free radical scavenging assays (DPPH radical and ABTS radical cation). This allowed to assess the relative influence of the groups bonded to the tetronic ring and to the exocyclic double bond on the activity, as well as the importance of this exocyclic double bond. It was shown that the presence of an electron-donating group on the 3-position of the tetronic ring had a beneficial effect. It was shown in several assays that the presence of the exocyclic bond was not crucial to the activity.Bioorganic & medicinal chemistry 09/2010; 18(22):7931-9. · 2.82 Impact Factor -
Article: Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
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ABSTRACT: In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property. The radioprotective activity has also been evaluated in mice. Some of these compounds could be good radioprotectors.Bioorganic & medicinal chemistry 06/2009; 17(14):5275-84. · 2.82 Impact Factor
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Institutions
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2009–2010
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Université Paul Sabatier - Toulouse 3
Toulouse, Midi-Pyrenees, France
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