[Show abstract][Hide abstract] ABSTRACT: This article is about resettled Afghan Hazaras in Australia, many of whom are currently undergoing a complex process of transition (from transience into a more stable position) for the first time in their lives. Despite their permanent residency status, we show how resettlement can
be a challenging transitional experience. For these new migrants, we argue that developing a sense of belonging during the transition period is a critical rite of passage in the context of their political and cultural identity. A study of forced migrants such as these, moving out of one transient
experience into another transitional period (albeit one that holds greater promise and permanence) poses a unique intellectual challenge. New understandings about the ongoing, unpredictable consequences of ‘transience’ for refugee communities is crucial as we discover what might
be necessary, as social support structures, to facilitate the process of transition into a distinctly new environment. The article is based on a doctoral ethnographic study of 30 resettled Afghan Hazara living in the region of Dandenong in Melbourne, Australia. Here, we include four of these
participants’ reflections of transition during different phases of their resettlement. These reflections were particularly revealing of the ways in which some migrants deal with change and acquire a sense of belonging to the community. Taking a historical view, and drawing on Bourdieu’s
notion of symbolic social capital to highlight themes in individual experiences of belonging, we show how some new migrants adjust and learn to ‘embody’ their place in the new country. Symbolic social capital illuminates how people access and use resources such as social networks
as tools of empowerment, reflecting how Hazara post-arrival experiences are tied to complex power relations in their everyday social interactions and in their life trajectories as people in transition. We learned that such tools can facilitate the formation of Hazara migrant identities and
are closely tied to their civic community participation, English language development, and orientation in, as well as comprehension of local cultural knowledge and place. This kind of theorization allows refugee, post-refugee and recent migrant narratives to be viewed not merely as static
expressions of loss, trauma or damage, but rather as individual experiences of survival, adaptation and upward mobility.
Cancer cell 07/2010; 18(1):52-62. DOI:10.1016/j.ccr.2010.04.028 · 23.52 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be associated with carcinogenesis. Here, the expression of VHZ associated with cell growth and human cancers was investigated.
We generated a mouse monoclonal antibody (mAb clone#209) and rabbit polyclonal antibodies (rAb) against VHZ. We performed cell proliferation assay to learn how VHZ is associated with cell cycle by retroviral transduction to express VHZ, VHZ(C95S), and control vector in MCF-7 cells. Overexpression of VHZ [but not VHZ(C95S)] in MCF-7 cells promoted cell proliferation compared to control cells. shRNA-mediated knockdown of VHZ in MCF-7 cells showed that reduction of VHZ resulted in increased G1 but decreased S phase cell populations. Using indirect immunofluorescence, we showed that both exogenous and endogenous VHZ protein was localized at the centrosome in addition to its cytoplasmic distribution. Furthermore, using immunohistochemistry, we revealed that VHZ protein was overexpressed either in enlarged centrosomes (VHZ-centrosomal-stain) of some invasive ductal carcinomas (IDC) Stage I (8/65 cases) or in entire cytoplasm (VHZ-cytosol-stain) of invasive epithelia of some IDC Stage II/III (11/47 cases) of breast cancers examined. More importantly, upregulation of VHZ protein is also associated with numerous types of human cancer, in particular breast cancer. VHZ mAb may be useful as a reagent in clinical diagnosis for assessing VHZ positive tumors.
We generated a VHZ-specific mAb to reveal that VHZ has a novel subcellular localization, namely the centrosome. VHZ is able to facilitate G1/S cell cycle transition in a PTP activity-dependent manner. The upregulation of its protein levels in primary human cancers supports the clinical relevance of the protein in cancers.
Molecular Cancer 05/2010; 9(1):128. DOI:10.1186/1476-4598-9-128 · 4.26 Impact Factor