Caroline Pasteris

Publications (2)8.72 Total impact

• Source

  Available from: miracd.com

  Article: Impaired fMRI activation in patients with primary brain tumors.

  Zhen Jiang, Alexandre Krainik, Olivier David, Caroline Salon, Irène Troprès, Dominique Hoffmann, Nicolas Pannetier, Emmanuel L Barbier, Eduardo Ramos Bombìn, Jan Warnking, Caroline Pasteris, Stefan Chabardes, François Berger, Sylvie Grand, Christoph Segebarth, Emmanuel Gay, Jean-François Le Bas
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  ABSTRACT: To characterize peritumoral BOLD contrast disorders, 25 patients referred for resection of primary frontal or parietal neoplasms (low-grade glioma (LGG) (n=8); high-grade glioma (HGG) (n=7); meningioma (n=10)) without macroscopic tumoral infiltration of the primary sensorimotor cortex (SM1) were examined preoperatively using BOLD fMRI during simple motor tasks. Overall cerebral BOLD signal was estimated using vasoreactivity to carbogen inhalation. Using bolus of gadolinium, cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were estimated. In a 1cm(3) region-of-interest centered on maximal T-value in SM1 contralateral to movements, interhemispheric asymmetry was evaluated using interhemispheric ratios for BOLD and perfusion parameters. During motor tasks contralateral to the tumor, ipsitumoral sensorimotor activations were decreased in HGG and meningiomas, correlated to the distance between the tumor and SM1. Whereas CBV was decreased in ipsitumoral SM1 for HGG, it remained normal in meningiomas. Changes in basal perfusion could not explain motor activation impairment in SM1. Decreased interhemispheric ratio of the BOLD response to carbogen was the best predictor to model the asymmetry of motor activation (R=0.51). Moreover, 94.9+/-4.9% of all motor activations overlapped significant BOLD response to carbogen inhalation.
  NeuroImage 08/2010; 52(2):538-48. · 5.89 Impact Factor
• Article: Perfusion-sensitive MRI of pilocytic astrocytomas: initial results.

  Sylvie D Grand, Stéphane Kremer, Irène M Tropres, Dominique M Hoffmann, Stephan J Chabardes, Virginie Lefournier, François R Berger, Caroline Pasteris, Alexandre Krainik, Basile M Pasquier, Michel Peoch, Jean François Le Bas
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  ABSTRACT: To present the imaging and perfusion data obtained in nine patients with pilocytic astrocytomas (PA) and to discuss the original functional issues of this technique. Nine patients with pathologically proven PA underwent conventional and perfusion MR imaging. Various areas of relative cerebral blood volume (rCBV) within the tumors were obtained. The maximum rCBV ratios were identified and considered as representative of the tumor. The results were compared with the pathological findings. In all patients, rCBV was <1.5 (mean 1) and the signal intensity curve overshot the baseline. PA tend to have low rCBV values and a first-pass curve that crosses the baseline. These characteristics may be explained by the histological profile of the tumoral vascularity and are of relevance in the identification of these rare tumors.
  Neuroradiology 07/2007; 49(7):545-50. · 2.82 Impact Factor