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ABSTRACT: The isotachophoretic separation of some isoquinoline alkaloids in acid-base partially purified extracts from Bulgarian FUMARIA PARVIFLORA was studied. The electrolyte system for model mixtures of alkaloids (-)-stylopine, (-)-canadine, coptisine, berberine, protopine, cryptopine, chelidonine, bulbocapnine, papaverine, parfumine and for the plant extracts contained the leading ion K (+) (0.01 M), counter ion CH (3)COO (-), pH (L) 5.5, and the terminating ion H (+) (acetic acid 0.01 M). In the plant extracts, protopine and parfumine were quantitatively determined during F. PARVIFLORA growth and development in the term May-June 1984.
Planta Medica 09/1985; 51(4):319-22. · 2.15 Impact Factor
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Planta Medica 07/1985; 51(3):286. · 2.15 Impact Factor
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Planta Medica 03/1985; 51(1):72. · 2.15 Impact Factor
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Acta Universitatis Palackianae Olomucensis Facultatis Medicae 02/1985; 111:23-36.
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ABSTRACT: A rapid isotachophoretic separation of benzo[ C]phenanthridine alkaloids from CHELIDONIUM MAJUS L. is described. The method allows the determination of sanguinarine and chelerythrine in the presence of other isoquinoline alkaloids in crude alkaloids extracts.
Planta Medica 05/1984; 50(2):149-51. · 2.15 Impact Factor
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Acta Universitatis Palackianae Olomucensis Facultatis Medicae 02/1984; 107:159-62.
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Planta Medica 08/1983; 48(3):174-7. · 2.15 Impact Factor
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ABSTRACT: FUMARIA DENSIFLORA DC., collected near Varna (Bulgaria) was investigated for its alkaloidal content. Protopine, cryptopine, coptisine, palmatine, adlumidiceine, (+/-)-sinactine, and a new spirobenzylisoquinoline alkaloid densiflorine were isolated. Benzophenanthridine alkaloids were not detected.
Planta Medica 08/1983; 48(8):272-4. · 2.15 Impact Factor
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ABSTRACT: The inhibition of butyrylcholinesterase activity in human serum by protoberberine, benzophenanthridine and aporphine alkaloids as well as four model compounds has been studied. The mechanism of the inhibition is discussed on the basis of the different types of interaction of these compounds with butyrylcholinesterase and acetylcholinesterase.
Planta Medica 07/1983; 48(7):174-7. · 2.15 Impact Factor
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Planta Medica 07/1983; 48(2):111-5. · 2.15 Impact Factor
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ABSTRACT: From Fumaria parviflora Lam. were isolated the major alkaloids protopine and adlumidiceine and the minor alkaloids parfumine, fumariline, dihydrofumariline, cryptopine, (-)-stylopine, 8-oxocoptisine, sanguinarine, and oxysanguinarine. The quaternary protoberberine fraction gave coptisine. Adlumidiceine, dihydrofumariline, 8-oxocoptisine, sanguinarine, and oxysanguinarine were found in F. parviflora for the first time. F. kralikii Jordan gave, besides the major alkaloids protopine, fumarophycine, and O-methylfumarophycine, the alkaloids adlumidiceine, berberine, coptisine, cryptopine, (-)-stylopine, and (-)-canadine. Only protopine and cryptopine have been isolated from F. kralikii earlier.
Planta Medica 06/1982; 45(2):120-2. · 2.15 Impact Factor
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Acta Universitatis Palackianae Olomucensis Facultatis Medicae 02/1982; 103:147-53.
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Planta Medica 11/1981; 43(2):161-5. · 2.15 Impact Factor
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ABSTRACT: The quaternary benzophenanthridine alkaloids sanguinarine (1) and chelerythrine (2) inhibit rat liver L-alanine-:2-oxoglutarate aminotransferase (EC 2.6.1.2) activity. Nitidine (3) has no inhibitory effect. The inhibitory activity of alkaloids depends on the reactivity of the iminium bond with the nucleophilic reagent, e.g., the thiol group. The stability constants of adduct formation for thioethanol, cysteine, and glutathione with sanguinarine (1) and chelerythrine (2) are given. The mechanism of the inhibition of alanine aminotransferase activity by the alkaloids 1 and 2 is discussed.
Journal of Medicinal Chemistry 10/1981; 24(9):1100-3. · 5.25 Impact Factor
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ABSTRACT: It was found that the so far described variations in the content of colchicine alkaloids in leaves and flowers of Colchicum autumnale L. and C. byzantinum Ten. are due to enzymatic O-demethylation and degradation of colchicine (I), N-deacetyl-N-formylcolchicine (XI), and demecolcine (XVII) during drying and storing of the plant material. A simplified method was elaborated to separate the neutral, phenolic, basic, and basic-phenolic fractions of tropolone alkaloids.
Planta Medica 10/1981; 43(2):153-60. · 2.15 Impact Factor
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ABSTRACT: On the basis of alkaloidal, morphological and chromosomal studies, the section Mecones Bernh. (Syn.: Papaver L., sect. Papaver) has been subdivided into two sections. Thus the new section Glauca J. Novak includes the species Papaver glaucum Boiss. et Hausskn., P. gracile Auch. and P. decaisnei Hochst. et Steud., whereas the section mecones Bernh. only the species P. somniferum L. and P. setigerum Dc. The major alkaloids of the species of the section mecones are the morphinane alkaloids morphine and codeine, whereas those of the section Glauca the rhoeadine and the papaverrubines. The section mecones has the basic chromosome number x = 11, and the section Glauca x = 7. The basic chromosome numbers have been correlated with the morphological features.
Planta Medica 02/1981; 41(2):119-23. · 2.15 Impact Factor
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Planta Medica 07/1979; 36(2):119-27. · 2.15 Impact Factor
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Bratislavske lekarske listy 05/1978; 69(4):386-401. · 0.40 Impact Factor
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ABSTRACT: From Corydalis cava (L.) Sch. et K. (C. tuberosa DC) (Papaveraceae: genus Corydalis Med.), a mixture of alkaloids (0.53%) was isolated. The main alkaloid was (+)-bulbocapnine, and the minor alkaloids were coptisine, (+)-domestine, adlumidiceine, (+)-predicentrine, protopine, (-)-capnoidine, (+)-stylopine, (+)-isoboldine, 8-oxocoptisine, 1,2-methylenedioxy-6a,7-dehydroaporphine-10,11-quinone, and corysamine. In addition, fumaric acid was obtained. Coptisine, adlumidiceine, predicentrine, 8-oxocoptisine, corysamine, 1,2-methylenedioxy-6a, 7-dehydroaporphine-10,11-quinone, and isoboldine were found in C. cava for the first time, but rhoeadine and papaverrubine alkaloids were not detected. Predicentrine and isoboldine were identified on the basis of the UV, IR, mass, and PMR spectra.
Journal of Pharmaceutical Sciences 03/1976; 65(2):294-6. · 3.06 Impact Factor
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Planta Medica 12/1975; 28(3):210-4. · 2.15 Impact Factor