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ABSTRACT: The purpose of this study is to assess patient, tumour and treatment related factors on quality of life (QoL) outcomes of
patients who received definitive or postoperative radiotherapy±chemotherapy for head and neck (H&N) cancer. In this cross-sectional
study, 110 H&N cancer patients were evaluated in follow-up visit and were asked to fill out the European Organisation for
Research and Treatment of Cancer QoL Core Questionnaire (QLQ-C-30) and H&N Module (QLQ-H&N35). Patients were also graded for
their late side effects using EORTC/RTOG scoring system. The QLQ C-30 and QLQ-H&N35 mean scores were compared using ANOVA
analysis for these variables: age, gender, occupation, educational status, social security status, place of residence, tumour
localization, clinical stage, comorbidity, Karnofsky performance score, treatment modality and side effects. Median follow-up
was 29 (4–155)months. Tumour localization was significant factor affecting physical (P=0.03), social (P=0.01), cognitive (P=0.002) functioning. Treatment modality had significant impact on the physical (P=0.02) and cognitive scores (P=0.008). Global QoL was affected significantly by disease stage (P=0.01) and occupation (P=0.01). The QLQ-H&N35 scores were found significantly higher in patients with moderate/severe late morbidity. Tumour localization
and the treatment modality are the most important factors affecting the QoL of H&N cancer patients treated definitively.
Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 09/2008; 266(9):1461-1468. DOI:10.1007/s00405-008-0889-0 · 1.61 Impact Factor
Journal of Thoracic Oncology 08/2007; 2(Supplement 4). DOI:10.1097/01.JTO.0000284148.18927.e8 · 5.80 Impact Factor
Journal of Thoracic Oncology 01/2007; 2. DOI:10.1097/01.JTO.0000284147.41798.cf · 5.80 Impact Factor
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ABSTRACT: To compare ultrasonographic (US) with computerized tomographic (CT) images in order to choose electron energy for radiotherapy (RT) boost field in patients with breast conserving surgery (BCS).
Thirty-seven consecutive patients with breast cancer treated by BCS and RT in our department were evaluated. Median age was 49 years (range 32-82). According to the Dokuz Eylul Breast Tumor Group Protocol (DEBTG), in patients with BCS, RT (5000 cGy to the whole breast ± lymphatic area) and boost with electron energy to the primary tumor bed (1000 cGy if surgical margin negative, or 1600 cGy if surgical margin positive was delivered. Before January 2003, the distances between skin-the deepest point of tumor bed (STD), skin-clips (SCD), and skin-fascia (SFD) were measured with US to choose electron energy in boost field. Since then, CT simulation images were used to this purpose. These two imaging systems were compared in this study. Electron energy was selected after measurement of the deepest metallic clips in CT simulation images (90%) or measurement of the STD if no clips were present (10%).
Median measurements with US and CT were as follows: STD: US 12 mm (range 4-35), CT 28 mm (range 2-54); SFD: US 25 mm (range 6-57), CT 31 mm (range 2-93); SCD: US 14 mm (range 7-26), CT 29 mm (range 2-68). The median electron energy was 9 MeV é (range 6-12) for US and 12 MeV é (range 6-21) for CT. Concordance in US and CT measurements was 27%.
This preliminary study reveals that CT-based SCD measurements are deeper than US measurements, and selected electron energy with CT is 3 MeV higher than US. These two factors can affect local control and side effects. We noticed only one local recurrence in 37 patients. We did not evaluate side effects in this study. These could be a subject of a future study.
Journal of B.U.ON.: official journal of the Balkan Union of Oncology 15(3):500-3. · 0.71 Impact Factor