Bei-En Zhang

Publications (2)0 Total impact

• Article: [Screening of anti-diarrhea effective fractions from guava leaf].

  Wen-biao Lu, Bei-en Zhang, Jing Wang, Rui-xin Lu, Ru-liu Li, Wei-wen Chen
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  ABSTRACT: To screen the fractions from guava leaf to ascertain the effective anti-diarrhea fraction and to establish the method of quality control. A series of samples from guava leaf were prepared through extraction and separation by solvents progressively, and their effect on the mice diarrhea models induced by senna decoction were tested individually; and the constituent correlated with the effect of the samples on the models was determined by HPLC. The effect of the fractions with moderate-polar glucosides from guava leaf was better than that of the other fractions; the effect of the fractions with the glucosides was correlated with the content of the quercetin glucosides in the fractions. The fractions with the moderate-polar glucosides is the effective anti-diarrhea fraction of guava leaf; determination of the quercetin glucosides can be used for quality control of guava leaf and its extracts.
  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 05/2010; 33(5):732-5.
• Article: [Study on self-microemulsifying drug delivery system of Jiaotai Pill active components].

  Bei-En Zhang, Wen-Biao Lu, Wei-Wen Chen
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  ABSTRACT: To develop self-microemulsifying drug delivery system (SMEDDS) of Jiaotai Pill active components and its quality control method. The solubility of berberine hydrochloride in different auxiliary-materials were investigated, and the self-microemulsion formula was optimized by studying the self-microemulsifying efficiency. The content of berberine hydrochloride and cinnamaldehyde in the preparation were determined by HPLC. The optimal self-microemulsion formula was composed of OP, propanediol, cinnamon oil, and total alkaloid from Rhizoma Coptidis with the ratio of 4:8:3:6. The average size of the microemulsion particle was 15.8 nm; the average content of berberine hydrochloride and cinnamaldehyde in the preparation was above 20.0% and 10.0%, respectively. The acquired microemulsion with small particle size is stable. The determination method of berberine hydrochloride and cinnamaldehyde in the preparation is accurate and reliable.
  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 08/2008; 31(7):1068-71.