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ABSTRACT: Intervertebral discs (IVD) are specialized structures to anchor adjacent vertebral bodies conferring flexibility and providing
mechanical stability during axial compression1. Degeneration of IVD results in discogenic low back pain and limited mobility. Very recently, to overcome limited success
of current surgical treatment focused on fusion, few studies have been started by tissue engineering technique2,3. It has been recognized that tissue engineering offers an alternative techniques to whole organ and tissue transplantation
for diseased, failed or malfunctioned organs4,5. In tissue engineering of IVD, presence of disc cells harvested from IVD tissue of donor and proper scaffold is needed6–8.
Advances in experimental medicine and biology 02/2006; 585:167-81. · 1.83 Impact Factor