B. Dzamba

Publications (2)2.54 Total impact

• Article: Xenopus fibrillin is expressed in the organizer and is the earliest component of matrix at the developing notochord-somite boundary.

  P Skoglund, B Dzamba, C R Coffman, W A Harris, R Keller
  [show abstract] [hide abstract]
  ABSTRACT: We identify a Xenopus fibrillin homolog (XF), and show that its earliest developmental expression is in presumptive dorsal mesoderm at gastrulation, and that XF expression is regulated by mesoderm-inducing factors in animal cap assays. XF protein is also first detected in presumptive mesoderm, but is concentrated specifically into extracellular-matrix structures that begin to develop de novo by mid-gastrulation at both of the bilateral presumptive notochord-somite boundaries. Later in embryogenesis, XF protein is localized to the extracellular matrix at tissue boundaries, where it is found surrounding the notochord, the somites, and the neural tube, as well as under the epidermis. This pattern of protein deposition combines to give the appearance of an "embryonic skeleton," suggesting that one role for XF is to serve as a mechanical element in the embryo prior to bone deposition.
  Developmental Dynamics 08/2006; 235(7):1974-83. · 2.54 Impact Factor
• Source

  Available from: virginia.edu

  Conference Proceeding: Computational automata simulation of blastocoel roof thinning in the Xenopu laevis embryo

  D. Longo, S. Peirce, T. Skalak, M. Marsden, L. Davidson, B. Dzamba, D. DeSimone
  [show abstract] [hide abstract]
  ABSTRACT: Computer simulation of the interactions between numerous cells is a novel approach to analyzing and comprehending the spatial and temporal patterns that are formed in a large network of cells within a tissue. Coupled with experimental observation, computational modeling at the cellular level is a powerful method that is capable of providing valuable information about the functions of quite complex biological systems. For this study, the biological system under examination is the Xenopus laevis embryo. In the blastocoel roof of the Xenopus laevis embryo, thinning of multiple cell layers into two cell layers is accomplished via radial intercalation of the deep layer cells. A cell-based simulation has been developed to analzye the process of blastocoel roof (BCR) thinning event. The cellular automata model can predict important characteristics of the BCR thinning process including total thinning time and spatial fibronectin fibril densities.
  Systems and Information Engineering Design Symposium, 2003 IEEE; 05/2003