[Show abstract][Hide abstract] ABSTRACT: A study has been carried out to assess the potential use of pectin in combination with two added hydrocolloids, i.e., hydroxy-propyl-methyl cellulose and hydroxyethyl cellulose in varied concentrations and coated with ethyl cellulose and cellulose acetate phthalate. The results of in vitro drug release showed that the matrix tablets prepared with pectin, hydroxy ethyl cellulose (20 percent) when coated with ethyl cellulose and cellulose acetate phthalate were found to be 63.0 percent, 8.4 percent, and 4.5 percent, respectively, in after eight hours during drug release study period. These results were confirmed with the results of roentgenographic studies in nine healthy human volunteers to find the shape and integrity of the dosage form. The X-ray photographs revealed that the enteric-coated tablet was visible only up to 5.5 hours and at the end of eighth hour, the photograph has not shown any presence of tablet indicating the loss of shape and size by the microflora present in the colon region. So, the results of in vitro and roentgenographic studies revealed that pectin, hydroxy ethyl cellulose (20 percent) base coated with ethyl cellulose and cellulose acetate phthalate was found to be a promising carrier for naproxen to colon.
The Yale journal of biology and medicine 08/2003; 76(4-6):149-54.