Atish Chandra

Publications (2)4.45 Total impact

• Article: Copper-free palladium-catalyzed Sonogashira coupling-annulation: efficient one-pot synthesis of functionalized pyrano[4,3-b]quinolines from 2-chloro-3-formylquinolines.

  Atish Chandra, Bhawana Singh, Ranjana S Khanna, Radhey M Singh
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  ABSTRACT: A convenient, one-pot, copper-free, Pd-catalyzed methodology has been described for the synthesis of 1,3-disubstituted pyrano[4,3-b]quinolines from 2-chloro-3-formylquinolines. Formation of annulated products 3 is attributed to the presence of Pd(OAc)2 and PPh3. Further, PPh3 in the reaction mixture promotes the cyclization by reducing the reaction time and increasing the yield of cyclized product.
  The Journal of Organic Chemistry 07/2009; 74(15):5664-6. · 4.45 Impact Factor
• Article: Copper-free Sonogashira coupling of 2-chloroquinolines with phenyl acetylene and quick annulation to benzo[b][1,6]naphthyridine derivatives in aqueous ammonia

  Atish Chandra, Bhawana Singh, Shraddha Upadhyay, Radhey M. Singh
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  ABSTRACT: An efficient copper-free Sonogashira coupling of 2-chloroquinolines with phenyl acetylene to 2-ethynylquinolines is described. We further discussed the one pot facile annulation of 2-alkynylquinoline-3-carboxaldehydes to 3-phenylbenzo[b][1,6]naphthyridines in aqueous ammonia in excellent yield.Graphical abstract
  Tetrahedron. 64(51):11680-11685.