Publications (3)5.07 Total impact
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Article: Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls.
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ABSTRACT: The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. We examined the association of iron, copper and zinc between biological samples (scalp hair, whole blood and urine) and mortality from myocardial infarction (MI) patients of (first, second and third heart attack). The biological samples were from 130 MI patients (77 male and 53 female, age range 45-60 years) and 61 healthy age-matched controls (33 male and 28 female). The metals in the biological samples were measured by the flame atomic absorption spectrophotometry, prior to microwave assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials. During this study, 78% of the 32 patients aged >50 years, registered after the third MI attack died. In these subjects the concentration of Fe and Cu were increased by 0.83% and 3.12% in the scalp hair while in blood samples 9.7% and 22.5% were enhanced respectively, as compared to those who tolerated 3rd MI attack (p=0.072). The concentrations of Zn in whole blood and scalp hair samples were lower in MI patients as compared to normal subjects. Deficiency of zinc and high concentration of copper and iron may play a role in the development of heart disease.Clinica Chimica Acta 03/2008; 389(1-2):114-9. · 2.54 Impact Factor -
Article: Evaluation of zinc status in whole blood and scalp hair of female cancer patients.
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ABSTRACT: Zinc is essential for all life forms and plays a vital role in human nutrition and biochemical functions. Epidemiologic studies suggest that zinc deficiency may be associated with increased risk of cancer. We measured the concentration of Zn in whole blood and scalp hair of female patients with breast and ovarian cancers from different cities of Pakistan. Sixty-five patients (30-60 y) and 50 healthy subjects of the same age groups were included. Both controlled and study group female patients were of same socio-economic status, localities and dietary habits. The scalp hair and whole blood samples were oxidized by mixture of 65% nitric acid: 30% hydrogen peroxide (2:1) ratio in microwave oven, to reduce the conventional wet acid digestion period. The proposed method was validated by certified sample of human hair BCR 397 and Clincheck control-lyophilized human whole blood. The all digested samples were analyzed for Zn concentration using flame atomic absorption spectrometry (FAAS). There was a significant decrease in mean total of Zn in whole blood and scalp hair samples of both cancer groups of patients compared to a controlled healthy female group (p<0.001). There is an association of Zn with biological samples in different types of cancer in females.Clinica Chimica Acta 04/2007; 379(1-2):66-70. · 2.54 Impact Factor -
Article: Evaluation of zinc status in whole blood and scalp hair of female cancer patients
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ABSTRACT: Background: Zinc is essential for all life forms and plays a vital role in human nutrition and biochemical functions. Epidemiologic studies suggest that zinc deficiency may be associated with increased risk of cancer. Methods: We measured the concentration of Zn in whole blood and scalp hair of female patients with breast and ovarian cancers from different cities of Pakistan. Sixty-five patients (30–60 y) and 50 healthy subjects of the same age groups were included. Both controlled and study group female patients were of same socio-economic status, localities and dietary habits. The scalp hair and whole blood samples were oxidized by mixture of 65% nitric acid: 30% hydrogen peroxide (2:1) ratio in microwave oven, to reduce the conventional wet acid digestion period. The proposed method was validated by certified sample of human hair BCR 397 and Clincheck control-lyophilized human whole blood. The all digested samples were analyzed for Zn concentration using flame atomic absorption spectrometry (FAAS). Results: There was a significant decrease in mean total of Zn in whole blood and scalp hair samples of both cancer groups of patients compared to a controlled healthy female group (p b 0.001). Conclusion: There is an association of Zn with biological samples in different types of cancer in females.
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2007
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University of Sindh
- National Centre of Excellence in Analytical Chemistry
Jamshoro, Sindh, Pakistan
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