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ABSTRACT: Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2. Transforming the lactone moiety of the furanone to an imidate or an ortho-ester with a hydrophilic, endogenous appendage resulted in water soluble pro-drugs that converted to the parent drug in vivo.
Bioorganic & Medicinal Chemistry Letters 06/2005; 15(9):2259-63. DOI:10.1016/j.bmcl.2005.03.009 · 2.33 Impact Factor