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Publications (10)0 Total impact

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    ABSTRACT: Type 2 diabetes is associated with multiple abnormalities, all of which can contribute to vascular disease. The most notable of these abnormalities include obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and renal disease. Although a number of these disorders are often grouped together in an entity termed "metabolic syndrome,” the increased risk for atherosclerotic disease in insulin-resistant patients correlates best with these abnormalities when each is considered individually. These abnormalities promote heart disease by inducing atherosclerosis, endothelial cell dysfunction, oxidative stress, inflammation, and vascular remodeling. This review article is focused on the prevalence of diabetes mellitus in patients with acute myocardial infarction and to determine whether cardiac markers along with routine biochemical markers measured at admission could be used to diagnose the interrelation between Myocardial infarction and diabetes mellitus.
    Int J Cur Bio Med Sci. 01/2011; 1:30-34.
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    ABSTRACT: Background: Clinicopathological correlations, as well as several angiographic studies, suggest that diabetic patients have more extensive atherosclerotic disease, affecting the coronary arteries in particular. We sought to examine the combinational effect of cardiac and biochemical markers in diabetic patients with cardiovascular disease. Method: The study population constituted 50 healthy subjects, 50 cardiovascular subjects with diabetes and 50 cardiovascular subjects without diabetes. The population was subjected to biochemical and cardiac marker analysis and the results were verified. Results and discussion: Studies suggest that glycated hemoglobin values in the abnormal range can identify persons at increased risk for coronary heart disease, stroke, and death before the diagnosis of diabetes, indicating that glycated hemoglobin is a useful marker of cardiovascular risk and death from any cause.
    Int J Cur Bio Med Sci. 01/2011; 1:72-81.
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    ABSTRACT: Smoking is a major cause for several types of cancer. Smoking increases the risk of cancers of the lungs, bladder, cervix, kidney, larynx (voice box), pharynx (upper throat), nose, mouth, oesophagus (foodpipe), pancreas, stomach, liver and some types of leukaemia. And smokers are 7 times more likely to die of these cancer than non-smokers. Scientists have identified about 4,000 different chemicals in tobacco smoke. Chemicals such as nitrosamines, benzo(a)pyrene, benzene, acrolein, cadmium, and polonium-210 can damage DNA.Within this review article we will focus on the correlation between smoking and oxidative stress and the role of smoking in increasing the risk of gastric cancer .
    Int J Biol Med Res. 01/2011; 2:593 - 602.
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    ABSTRACT: Cigarette smoke contains mutagenic chemicals that are in the “probably carcinogenic” or “possibly carcinogenic” categories. In addition to free radicals, cigarette smoke is also rich in combustion toxic gases that can reach a very high concentration and become involved in more radical formation. Smoking increases the risk of cancers of the lungs, bladder, cervix, kidney larynx (voice box), pharynx (upper throat), nose, mouth, oesophagus (foodpipe), pancreas stomach, liver and some types of leukaemia. Within this review article we will focus on the correlation between smoking and oxidative stress and the role of smoking in increasing the risk of gastric cancer.
    Int J Cur Biomed Phar Res. 01/2011; 1:48-66.
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    ABSTRACT: Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases. Studies have found that the ability of a particular statin to lower or reduce LDL is proportional to the amount it can increase HDL levels. This review article will focus on the effective role of statin in cardiovascular disease and comparison was made between various classes of statin drugs.
    Int J Cur Sci Res. 01/2011; 1:47 - 56.
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    ABSTRACT: Type 2 diabetes is associated with multiple abnormalities, all of which can contribute to vascular disease. The most notable of these abnormalities include obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and renal disease. Although a number of these disorders are often grouped together in an entity termed "metabolic syndrome,” the increased risk for atherosclerotic disease in insulin-resistant patients correlates best with these abnormalities when each is considered individually. These abnormalities promote heart disease by inducing atherosclerosis, endothelial cell dysfunction, oxidative stress, inflammation, and vascular remodeling. This review article is focused on the prevalence of diabetes mellitus in patients with acute myocardial infarction and to determine whether cardiac markers along with routine biochemical markers measured at admission could be used to diagnose the interrelation between Myocardial infarction and diabetes mellitus.
    Int J Cur Bio Med Sci. 01/2011; 1:72 - 81.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Clinicopathological correlations, as well as several angiographic studies, suggest that diabetic patients have more extensive atherosclerotic disease, affecting the coronary arteries in particular. We sought to examine the combinational effect of cardiac and biochemical markers in diabetic patients with cardiovascular disease. Method: The study population constituted 50 healthy subjects, 50 cardiovascular subjects with diabetes and 50 cardiovascular subjects without diabetes. The population was subjected to biochemical and cardiac marker analysis and the results were verified. Results and discussion: Studies suggest that glycated hemoglobin values in the abnormal range can identify persons at increased risk for coronary heart disease, stroke, and death before the diagnosis of diabetes, indicating that glycated hemoglobin is a useful marker of cardiovascular risk and death from any cause.
    Int J Cur Bio Med Sci. 01/2011; 1:30 - 34.
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    ABSTRACT: Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease (secondary prevention). The effectiveness of various statin drugs in hyperlipidaemic patients is evaluated in the present study. This work was undertaken to assess the effective role of statin in hyperlipidaemic patients with cardiovascular disease and comparison was made between various classes of statin drugs. The study population contained 50 subjects with hyperlipidaemia and they were administered with statin class of drugs. The administration of Rosuvastatin and Atrovastatin was found to be more effective in the treatment of hyperlipidaemic patients than that of Simvastatin and Pravastatin. Although flavostatin also had a profound effect, the dosage was high compared to other statins. Hence its effectiveness compared to Rosuvastatin and Atrovastatin need to be further investigated. Rosuvastatin and Atrovastatin can be more effective in reducing hyperlipidemia compared to other classes of statin drugs and thus further reduce the risk of cardiovascular disease in such patients.In addition to that,Rosuvasatin had less side effects in patients as compared to atrovastatin and can be defined as the most effective among the statin class of drugs.
    Int J Cur Biomed Phar Res. 01/2011; 1:06 - 10.
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    ABSTRACT: Back ground: Gestational diabetes mellitus, characterized by glucose intolerance during pregnancy has many risk factors associated with it. Some studies have shown a strong association between smoking and glucose intolerance during pregnancy. We sought to examine the role of smoking as modifiable risk factor for gestational diabetes. Method: A systematic review of articles published upto 2010 using pub med, Embase, Science direct along with manual search through literature contributed to the present study. We focused on studies related to the effect of smoking on gestational diabetes and heterogeneity analysis was performed. Results: We analyzed data from 39 studies and 14 were included in the review. Majority of the studies indicate smoking as dose-dependent modifiable risk factor for gestational diabetes. Other studies do not support this finding. Conclusion: On the analysis of different studies regarding smoking and gestational diabetes, Current data give enough evidence to support the fact that smoking may be considered as a modifiable risk factor for gestational diabetes.
    International Journal of Biological and Medical Research (IJBMR). 01/2010; 1:105 - 119.
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    ABSTRACT: For over last two decades, the toxicological research has focussed on pesticide-induced oxidative stress (OS) as a possible mechanism of toxicity. In fact OS is an outcome of a multistep process spanning from perturbations in the balance between the levels of oxidants / prooxidants and antioxidants (both enzymatic and non-enzymatic) to tissue damage leading to onset of several disease states and finally to apoptosis. The mechanism(s) of pesticides induced oxidative stress, however, is still not completely understood. Further, several other factors (called as risk factors) are thought to be associated with potentiation of the impact of pesticides induced oxidative stress in living systems and hence play crucial role in the evaluation of safety or toxicity of the pesticide concerned. In recent years several attempts have been made to understand pesticide induced OS in terms of monitoring alterations in various biochemical and molecular compositions in different organs of some experimental animal models by exposing them to varying acute and sub-acute doses of pesticides. It is important therefore to explore some plant products or drugs, which could help mitigate the adverse effects of reactive oxygen species (ROS) including free radicals (FR) produced due to pesticides exposure. This review presents an updated account of reported cellular and molecular events taking place in mammalian systems due to pesticide induced OS, factors influencing its toxicity, and its amelioration through application of various antioxidants.
    Int J Biol Med Res. 01/2010; 1:105-119.