Alla I Kuchto

Publications (1)2.83 Total impact

• Article: The synthesis of functionalized 13,14-seco-steroids via Grob fragmentation.

  Vladimir A Khripach, Vladimir N Zhabinskii, Galina P Fando, Alla I Kuchto, Alexander S Lyakhov, Alla A Govorova, Marinus B Groen, Jaap van der Louw, Aede de Groot
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  ABSTRACT: A synthetic methodology for the synthesis of 13,14-seco-steroids with substituents at C-14 and C-17 is described. The approach involves Grob fragmentation of 14beta-hydroxy-17beta-tosylates, hydroboration-oxidation of the intermediate delta13(17)-olefin, and hydride reduction of the 14-ketone. An unambiguous structural assignment of (13R,14S,17S)-14,17-diacetoxy-3-methoxy-7alpha-methyl-13,14-secoestra-1,3,5(10)-triene was determined by X-ray analysis.
  Steroids 08/2004; 69(7):495-9. · 2.83 Impact Factor