Publications (3)0.68 Total impact
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ABSTRACT: To determine the frequency of autoimmune thyroid disease in diagnosed cases of chronic urticaria (CU) and the association between hypothyroidism and chronic urticaria if any. Non-interventional, descriptive study. Department of Physiology, Dow University of Health Sciences, Karachi, from December 2004 to January 2006. The patients were selected from Department of Dermatology and Medical Units of Civil Hospital, Jinnah Postgraduate Medical Centre, the Aga Khan Hospital and community clinics. A total number of 60 patients were enrolled in this study. In all patients, serum antithyroid autoantibodies (antithyroglobulin and antimicrosomal/thyroperoxidase), thyroid profile (serum TSH, T3 and FT4), complete blood count, erythrocyte sedimentation rate and IgE levels were carried out. The proportions were compared using chi-square test with significance at p < 0.05. Forty seven (78%) patients were found to have chronic urticaria (history and laboratory reports). Out of 47 patients with diagnosis of CU, elevated titres of antithyroglobulin (TGA) and antimicrosomal antibodies (TMA) were found to be present in 20 (42.6%) and 27 (57.4%) patients respectively. Serum TSH level (thyroid stimulating hormone) was increased and T3, FT4 were decreased in 20 (42.6%) patients (p < 0.001). A total number of 20 (42.5%) patients were found to be hypothyroid with chronic urticaria of greater than 6 weeks duration. This study shows a statistically significant association between hypothyroidism and chronic urticaria. Full thyroid profile (serum thyroid autoantibodies, serum TSH, T3 and FT4) is highly recommended in patients with diagnosis of chronic urticaria.Journal of the College of Physicians and Surgeons--Pakistan: JCPSP 03/2010; 20(3):158-61. · 0.34 Impact Factor
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ABSTRACT: To determine the frequencies of serum antithyroglobulin and antimicrosomal autoantibodies in female patients with chronic urticaria, and the association between thyroid autoantibodies and chronic urticaria, if any. Non-interventional, case-control analytic study. This study was carried out by the Department of Physiology, Dow University of Health Sciences, Karachi, from December 2004 to January 2006 on patients selected from Department of Dermatology and Medical Units of Civil Hospital, Jinnah Postgraduate Medical Centre and The Aga Khan University Hospital, Karachi and from the Community Clinics in Karachi. A total number of 90 subjects were enrolled and divided in three groups consisting of 30 patients each. Group 1 comprised of patients with diagnosis of chronic urticaria, Group 2 of diagnosed cases of hypothyroidism with/without urticaria, and Group 3 of normal age and gender-matched healthy volunteers. In all patients, serum antithyroid autoantibodies (antithyroglobulin and antimicrosomal) and thyroid profile (serum T3, T4 and TSH levels) was carried out. Chi-square test was used to determine significance of proportion of variables at p < 0.05. Elevated titres of antithyroglobulin antibodies were found to be present in 9 (30%) patients in Group 1 (chronic urticaria), 24 (80%) patients in Group 2 (known cases of hypothyroidism) compared to control. Elevated titres of antimicrosomal antibodies were found to be present in 13 (43.3%) patients in Group 1, 27 (90%) patients in Group 2 (known cases of hypothyroidism) compared to control. The association between hypothyroidism and chronic urticaria with regard to autoantibodies titres was highly significance (p <0.001). A highly statistically significant association was found between chronic urticaria and hypothyroidism with special regard to antithyroglobulin and antimicrosomal autoantibodies. Therefore, assays of these two autoantibodies are justified for the early diagnosis of autoimmune thyroiditis in combination with chronic urticaria for better treatment options.Journal of the College of Physicians and Surgeons--Pakistan: JCPSP 09/2008; 18(8):498-501. · 0.34 Impact Factor
Article: LOW PRESSURE GLAUCOMA[show abstract] [hide abstract]
ABSTRACT: Background: To observe open angle glaucoma in the presence of low intra-ocular pressure. Methods: A descriptive cross-sectional study was done on 150 patients who attended the glaucoma clinic during one year from January 2005 to January 2006. A detailed history was obtained and a thorough ophthalmic examination was performed, including gonioscopy, ophthalmoscopy, applanation tonometery and automated perimetery. Results: Out of 150 patients of Primary open angle glaucoma 33 patients (22%) were found to have glaucoma at intra-ocular pressure level below normal (low pressure glaucoma), with mean age 56±9.21 years. Mean age of Primary open angle glaucoma group was 52.5±8.7%. Of the 33 cases of low-pressure glaucoma (22 patients) 66.6% were male and (11 patients) 33.4% were female, while in Primary open angle glaucoma (82 patients) 70% were male and (35 patients) 30% were female. Mean intra ocular pressure was 15.13±3.60 mm Hg in low-pressure glaucoma and 28±6.5 mm Hg) in Primary open angle glaucoma. Maximum intra ocular pressure in Low-pressure glaucoma group was 21 mm Hg and minimum Intra ocular pressure was observed as 8 mm Hg, while these values observed as 50 mm Hg and 10 mm Hg respectively in primary open angle glaucoma. Conclusions: Low pressure glaucoma remains a difficult diagnosis for ophthalmologist who favors the argument that raised Intra ocular pressure is essential for the diagnosis of Primary open angle glaucoma. Low pressure glaucoma changes the definition of glaucoma and our concept of intra ocular pressure as a sole etiological factor is now out dated. The overall frequency of Low pressure glaucoma in the current study was 22% among suspected cases of Primary open angle glaucoma.