Publications (1)2.47 Total impact
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Article: Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer.
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ABSTRACT: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer. To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma. Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively. A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.World Journal of Gastroenterology 07/2007; 13(24):3354-8. · 2.47 Impact Factor
