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Publications (5)7.5 Total impact

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    ABSTRACT: Cochlear implantation (CI) is a revolutionary method for hearing rehabilitation in patients with severe or profound sensorineural hearing loss. One of the surgical complications may be the necrosis of the skin flap above the receiver-stimulator coil, resulting in device extrusion. Our aim was to find the plausible causes of the silicone covered implant rejection. Authors present four cases of cochlear implant rejection, briefly describe their dermato-surgical solutions and analyse their innovative method - the epicutanoeus patch testing with silicone samples. They observed positive skin reaction in three of the four cases. Authors analyse the applicability and results of their surgical solutions and the epicutaneous testing in connection with the prevention of skin flap necrosis and rejection of silicone-covered cochlear implants.
    International journal of pediatric otorhinolaryngology 08/2013; · 0.85 Impact Factor
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    ABSTRACT: BACKGROUND: Fragrance mix II (FM II) was initiated to detect contact hypersenstitivity (CH) to fragrances that could not have been identified previously. OBJECTIVE: The aim of this multicenter study was to map the frequency of CH to FM II and its components in Hungary. METHODS: Six centers participated in the survey from 2009 to 2010. A total off 565 patients (434 women and 131 men) with former skin symptoms provoked by scented products were patch tested. The tests were performed with Brial GmbH D-Greven allergens. In the environmental patch test series, FM II, FM I, Myroxylon pereirae, colophonium, wood-tar mix, propolis, and sesquiterpene lactone mix were tested as fragrance allergens. The FM II components (citral, farnesol, coumarin, citronellol, α-hexyl-cinnamaldehyde, and hydroxy-isohexyl-3-cyclohexene-carboxaldehyde [Lyral]) were also tested. RESULTS: Contact hypersenstitivity to any fragrances was detected in 28.8%, to FM II in 17.2% of the patients. Contact hypersenstitivity to hydroxy-isohexyl-3-cyclohexene-carboxaldehyde was observed in 7.3%, to coumarin in 5.1%, to α-hexyl-cinnamaldehyde in 3.5%, to citral in 3.4%, to farnesol in 2.5%, and to citronellol in 1.2%. Of the FM II-positive cases, 48.4% showed isolated CH reaction. CONCLUSIONS: The frequency of CH to FM II is 17.2% in the tested, selected Hungarian population. The CH to FM II and its components could not have been revealed without the present test materials.
    Dermatitis 03/2012; 23(2):71-74. · 1.36 Impact Factor
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    ABSTRACT: A case is presented of subepidermal, autoimmune bullous disease in which the initial examinations suggested the combination of epidermolysis bullosa acquisita and bullous pemphigoid. The diagnosis of epidermolysis bullosa acquisita was made by indirect immunofluorescence microscopy: the patient's serum bound to normal skin substrate but not to type VII collagen-deficient skin substrate derived from a patient with mutilating dystrophic epidermolysis bullosa. The use of skin substrates deficient in basement membrane molecules also excluded the presence of concomitant, circulating bullous pemphigoid autoantibodies in our patient. The diagnosis of epidermolysis bullosa acquisita was confirmed by split mapping, fluorescence overlay antigen mapping and Western blot.
    European journal of dermatology: EJD 04/1998; 8(2):83-5. · 1.95 Impact Factor
  • Journal of Dermatological Science 03/1998; 16. · 3.34 Impact Factor
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    ABSTRACT: Korábbi vizsgálataink alapján célul tűztük ki, hogy megvizsgáljuk a prealbumin egyes szerkezeti elemeinek haptén hordozó szerepét és különböző gyógyszerekhez kapcsolva nagyszámú betegben meghatározzuk, növelhető-e a limfocita transzformációs teszt (LTT) diagnosztikus hatékonysága. 119 biztosan gyógyszer érzékenységben szenvedő beteg csak gyógyszerrel ill. gyógyszer-prealbumin peptid konjugátummal végzett párhuzamos LTT vizsgálata során nem találtunk konzekvens különbséget a gyógyszer-peptid javára az LTT vizsgálat érzékenységében. Gyógyszeraktiválást követően a különböző immunglobulinok (IgD, IgM, IgG) sejtfelszíni kifejeződése individuálisan változott a betegek B limfocitáin. 84 gén expresszióját vizsgáltuk 2 egészséges egyén és 4 gyógyszerallergiában szenvedő beteg izolált limfocitáin a gyógyszerindukciót követően, amely gének a CD4+ helper T limfociták TH1-TH2 típusaival voltak kapcsolatban. A betegek esetében az érzékenyítő gyógyszer hatására sokkal több vizsgált gén kifejeződésének növekedése következett be. Az is megállapítható volt, hogy a TH1 és TH2 típusú válaszok egyaránt indukálódnak a gyógyszerallergiás betegeknél, bár egyénenként különböző kifejeződési mintázatot mutattak. Eredményeink megerősítik azt a vélekedést, hogy a gyógyszerallergia mind klinikai megjelenésében és lefolyásában, mind immunológiai mechanizmusaiban heterogén kórkép, a TH1 és TH2 típusú válaszok keverednek. | Human prealbumin acting as a hapten-carrier protein in drug allergy was suggested by our previous investigations. The aim of the work was that different structural elements of prealbumin acting as hapten-carrier peptides, in conjugation of different drugs, are able to increase the diagnostic sensitivity of lymphocyte transformation test (LTT) in drug allergy patients comparing to simple drugs. Gene expressions of drug-specific lymphocytes during drug activation were also investigated. Unfortunately, drug-prealbumin conjugates as activators were not able to increase the diagnostic sensitivity of LTT test comparing to simple drug activation based on detailed parallel measurements in 119 patients with proved drug allergy. Immunoglobulin expressions (IgD, IgM, IgG) on the drug-induced B lymphocytes of the patients are individually varied compared to freshly isolated B lymphocytes of the patients as well as to healthy controls.We investigated the expressions of 84 genes (in connection with TH1 and/or TH2 immune response) in freshly separated and drug-induced lymphocytes isolated from healthy controls and patients with drug allergy. The expressions of a lot of genes are increased in the drug-induced lymphocytes of drug allergy patients, however, their expression patterns are varied individually. Our results supported that drug allergy is a heterogeneous disorder in its clinical picture and immunological mechanisms. Both TH1 and TH2 immune responses are involved in the pathogenesis.