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ABSTRACT: In recent years, pimecrolimus 1% cream has been demonstrated to reduce symptoms of atopic dermatitis in patients when applied topically.
In our study we compared the therapeutic effects of local 1% pimecrolimus to 1% hydrocortisone, and to a control group in a mouse model with atopic dermatitis in the external ear canals. Atopic dermatitis was created by application of Dinitrochlorobenzene in the external ear canals of mice. The development of atopic dermatitis was detected by clinical observation score and determination of total serum IgE levels. Pimecrolimus and hydrocortisone cream were topically applied to the external ear canal skin once a day for 14 days.
There was no significant difference between the hydrocortisone and the pimecrolimus therapy groups, while there was a statistically significant difference between these 2 groups and the control group (p<0.05) Assessment of the clinical observation scoring carried out on the 14th day of therapy revealed that there was no difference between the hydrocortisone and pimecrolimus groups. Biopsies were taken on the 14th day following treatment. Tissue samples were histologically evaluated; contact dermatitis was observed microscopically in the control group, but in the therapy groups only minimal evidence of contact dermatitis was found.
The results of our study reveal that the therapeutic efficacy of 1% pimecrolimus was equivalent to 1% hydrocortisone treatment in the artificially developed atopic dermatitis model in external ear canals of mice. These results clearly demonstrate that 1% pimecrolimus cream can be an effective alternative therapeutic agent in cases where steroid treatment proves to be insufficient or in cases where treatment must be discontinued due to its adverse effects.
Medical science monitor: international medical journal of experimental and clinical research 04/2012; 18(4):BR135-43. · 1.70 Impact Factor
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ABSTRACT: The purpose of the study was to compare children's reactions to inferior alveolar nerve injection with traditional syringe and periodontal ligament injection with a computerized device (Wand); and to assess the efficacy of the anesthesia and their reaction after treatment.
Twenty-five children, aged 6 to 10 years, participated in the study. The contralateral primary mandibular second molars were treated in 2 separate visits with random use of either the Wand or traditional syringe injection. The pain perception levels for each step were assessed with Eland Color Scale during the preparation. A Mann-Whitney U test was performed to compare the results. The patients were asked their preference of technique after the treatment.
When pain was measured immediately after injection, the traditional syringe was found to be more painful than injections with the Wand (P < .05). Pain scores with the Wand injections were found to be significantly (P < .05) higher than those with traditional inferior alveolar nerve injections at the end of the restoration. The overwhelming majority of patients favored the periodontal ligament injection with the Wand.
The Wand technique provided significantly lower pain scores during the periodontal ligament injection. However, the pain scores during the treatment were significantly higher compared with the inferior alveolar nerve injections. Most of the patients stated that they preferred the periodontal ligament injection with the Wand to the traditional inferior alveolar nerve injection.
Quintessence international 36(7-8):559-64. · 0.76 Impact Factor
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ABSTRACT: Implant dislocation following type 1 tyroplasty mostly results from the effects of triggering factors in the early postoperative period. A 42-year-old female patient who had had tyroplasty type 1 surgery with silastic implant, applied to our clinic with cough episodes, dyspnea and hoarseness following an upper airway infection 10 years after the surgery. In laryngeal endoscopic examination of the patient, white colored irregularity on anterior left vocal cord and left band ventricule fullness was seen. Regarding the patient's medical history, it was thought that the silastic prosthesis which had been implanted in the type 1 thyroplasty surgery might have displaced. The silastic prosthesis was removed by means of microsurgery technique through endolaryngeal way under general anesthesia. During the first month follow-up of the patient, dyspnea and hoarseness complaints were improved right away and she had no other problems. The causes and consequences of displacement of the prothesis which rarely occurs, after tyroplasty type 1 have been discussed along with the latest data in the literature.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 19(5):268-71.
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ABSTRACT: Zenker's diverticulum is a pulsion typed pharyngoeosophageal diverticle caused by the herniation of the pharyngeal mucosa, standing beside the posterior pharyngeal wall, through the Killian opening which is known as the weak area between the inferior constructor muscle's oblique fibres and transverse fibres of cricopharyngeal muscle. In patients with Zenker's diverticulum, symptoms such as disfagia, globus in the cervical area, weigh loss, regurgitation, cough, and aspiration. These patients are primarily admitted to the Gastroenterology and Othorhinolaryngology clinics with the complaint of disfagia and the diagnosis of this disease is mostly established late and the treatment is started late because the results of their physical examinations seem normal. Therefore, especially in the patients who have disfagia complaint, pharyngoeosophageal diverticle prediagnosis should be thought and that should be examined by passage graphies with barium and endoscopic methods, if needed. In this article, we presented the 67-year-old Zenker's diverticulum patient in whom we performed open diverticulectomy and posterior cricopharyngeal myotomy, and we specified the important points in choosing the patient and the type of surgery.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 19(6):311-5.
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ABSTRACT: Nasal obstruction is a very rare symptom caused by a pituitary adenoma. A 57-year-old man admitted to our clinic with bilateral nasal obstruction for the last six months. Endoscopic examination revealed soft pinkish pulsatile tissues in both nasal cavities. Radiologic investigation revealed a suprasellar mass extending to the frontal lobes, spheno-ethmoidal sinuses and nasal cavities. He had bitemporal superior quadrant hemianopsia. Pituitary hormone levels were normal. Biopsies were taken from the patient endonasally. Pathological evaluations and laboratory findings were compatible with nonfunctioning pituitary adenoma.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 20(6):309-13.
