Ruben Rodríguez-Mena

Consorcio Hospital General Universitario de Valencia, Valenza, Valencia, Spain

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Publications (11)4.42 Total impact

  • Carlos Barcia-Mariño, Ruben Rodríguez-Mena
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    ABSTRACT: Professor Juan José Barcia-Goyanes started neurosurgical practice from anatomy and neuropsychiatry in response to a vacancy at a department known as “Nervous diseases”, in 1931 at Hospital General in Valencia, Spain. Since the first intervention, based on the methods and surgical instruments already used in Europe and the U.S.A., the neurosurgical practice became the mainstay of the department, from which other auxiliary specialties emerged, such as neuroradiology, neurophysiology, neuropathology and also new techniques such as stereotactic surgery, functional neurosurgery and palencephalography. This year, the department celebrates its 80th anniversary. The broad spectrum of Prof. Barcia's scientific work included fields like neurology, neurosurgery and psychiatry, as well as anthropology, medical thought, history of medicine, morphology and history of anatomical language in his work “Onomatologica anatomica nova”, in addition to an interesting poetic work. He was a founding member of the Luso-Spanish Neurosurgical Society and the Neurosurgical Society of Levante.
    Neurocirugía. 01/2013; 24(6):262–271.
  • Carlos Barcia-Mariño, Ruben Rodríguez-Mena
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    ABSTRACT: Professor Juan José Barcia-Goyanes started neurosurgical practice from anatomy and neuropsychiatry in response to a vacancy at a department known as "Nervous diseases", in 1931 at Hospital General in Valencia, Spain. Since the first intervention, based on the methods and surgical instruments already used in Europe and the U.S.A., the neurosurgical practice became the mainstay of the department, from which other auxiliary specialties emerged, such as neuroradiology, neurophysiology, neuropathology and also new techniques such as stereotactic surgery, functional neurosurgery and palencephalography. This year, the department celebrates its 80th anniversary. The broad spectrum of Prof. Barcia's scientific work included fields like neurology, neurosurgery and psychiatry, as well as anthropology, medical thought, history of medicine, morphology and history of anatomical language in his work "Onomatologica anatomica nova", in addition to an interesting poetic work. He was a founding member of the Luso-Spanish Neurosurgical Society and the Neurosurgical Society of Levante.
    Neurocirugia (Asturias, Spain) 11/2012; · 0.34 Impact Factor
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    ABSTRACT: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade astrocytic tumour that usually occurs in the superficial cerebral hemispheres of children and young adults. Although it has a relatively favourable prognosis, malignant progression of these tumours has been described. Therefore, we present an unusual case of a 54-year-old male with a right, multicystic, parietooccipital tumour extending through the ipsilateral ventricle. After surgical resection, histological examination revealed a lesion with pleomorphic cells, cytoplasmic lipidisation, intensely eosinophilic granular bodies, well-delimitated unique nuclei and focal, positive immunoreactivity for synaptophysin, glial fibrillary acidic protein (GFAP), S-100 protein, vimentin and CD56. Once other tumours, such as giant cell metastatic carcinoma or primary lesion like subependymal giant cell astrocytoma, were ruled out, a final diagnosis of XAP was established. After a follow-up period of 9 months, the patient suffered an extensive and local tumour relapse considered inoperable, with progressive neurological deterioration and radiological findings of malignant progression. The brain biopsy procedure revealed anaplastic changes, including necrosis foci, higher mitotic activity (5×10 high-power fields) and a 10% proliferation index measured by Ki67 labelling. The present case showed intraventricular extension and a more aggressive behaviour, both uncommon in these tumours (similar to anaplastic astrocytoma or glioblastoma multiforme), thus demanding an initial, optimal surgical treatment with close clinical and radiological follow-up, due to the high potential for malignant transformation of XAPs.
    Neurocirugia (Asturias, Spain) 08/2012; 23(5):203-10. · 0.34 Impact Factor
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    ABSTRACT: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade astrocytic tumour that usually occurs in the superficial cerebral hemispheres of children and young adults. Although it has a relatively favourable prognosis, malignant progression of these tumours has been described. Therefore, we present an unusual case of a 54-year-old male with a right, multicystic, parietooccipital tumour extending through the ipsilateral ventricle. After surgical resection, histological examination revealed a lesion with pleomorphic cells, cytoplasmic lipidisation, intensely eosinophilic granular bodies, well-delimitated unique nuclei and focal, positive immunoreactivity for synaptophysin, glial fibrillary acidic protein (GFAP), S-100 protein, vimentin and CD56. Once other tumours, such as giant cell metastatic carcinoma or primary lesion like subependymal giant cell astrocytoma, were ruled out, a final diagnosis of XAP was established. After a follow-up period of 9 months, the patient suffered an extensive and local tumour relapse considered inoperable, with progressive neurological deterioration and radiological findings of malignant progression. The brain biopsy procedure revealed anaplastic changes, including necrosis foci, higher mitotic activity (5 × 10 high-power fields) and a 10% proliferation index measured by Ki67 labelling. The present case showed intraventricular extension and a more aggressive behaviour, both uncommon in these tumours (similar to anaplastic astrocytoma or glioblastoma multiforme), thus demanding an initial, optimal surgical treatment with close clinical and radiological follow-up, due to the high potential for malignant transformation of XAPs.
    Neurocirugía. 01/2012; 23(5):203–210.
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    ABSTRACT: Introducción: Los meduloblastomas son tumores malignos, invasivos, altamente celulares, del cerebelo, infrecuentes en el adulto. En el presente trabajo describiremos la experiencia en el manejo de esta patología en nuestro centro. Material y métodos: Se trata de un trabajo retrospectivo que incluyó 11 pacientes adultos con diagnóstico de meduloblastoma del eje craneoespinal atendidos entre 1984-2010. Se evaluaron datos clínicos, radiológicos y terapéuticos durante la evolución de la enfermedad. Resultados: La edad media de los pacientes fue 30,2 años (9 mujeres y 2 varones). Más del 80% de los pacientes manifestaron clínica de hipertensión intracraneal, mientras el 54,5% presentaron síndrome cerebeloso. El grado de resección quirúrgica fue total en 8 pacientes (72,7%) y subtotal en 3 (27,3%). Todos los pacientes recibieron tratamiento radioterápico adyuvante. Posterior a la exéresis tumoral inicial, 6 pacientes recibieron quimioterapia adyuvante con cisplatino (CDDP) y etopósido (VP-16). Durante el seguimiento, después de un tiempo medio de 35,2 meses, se observaron recidivas en el 36,4% de los pacientes (n= 4), con mayor frecuencia en la fosa posterior, empleando en todos ellos tratamiento con cirugía y quimioterapia. El tiempo medio de supervivencia fue 100,3 meses, con un índice de supervivencia estimado a los 5 y 8 años de seguimiento del 84 y 56 % respectivamente. Conclusiones: La máxima resección quirúrgica forma parte crucial del tratamiento, seguida de adyuvancia oncológica tan pronto sea posible, con radioterapia seguida o no de quimioterapia.
    Neurocirugia (Asturias, Spain) 12/2011; 22(6):488-497. · 0.34 Impact Factor
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    ABSTRACT: Medulloblastomas are malignant, invasive and highly cellular tumours from the cerebellum, rarely seen in adults. We describe the experience in the treatment of this entity in our institution. A retrospective study was made including 11 adult patients with medulloblastomas confined to the craniospinal axis treated between 1984-2010. Clinical, radiological and therapeutic data were assessed during the evolution of this entity. Mean age of patients was 30.2 years (9 women/2 men). Over 80% of the patients presented intracranial hypertension, while 54.5% presented cerebellum syndrome. Gross total surgical resection was achieved in 8 patients (72.7%) and subtotal resection in the other 3 (27.3%). All patients received craniospinal radiotherapy. After primary surgical resection, 6 patients received chemotherapy with cisplatin (CDDP) and etoposide (VP-16). During the follow up period and after a median time of 35.2 months, 4 patients (36.4%) presented with relapse, mainly in the posterior cranial fossa, managed in the majority of cases with surgical resection plus additional chemotherapy. Mean survival time was 100.3 months with a 5- and 8- year overall survival rate of 84 and 56% respectively. In the treatment of this malignancy, gross surgical resection has a crucial role, followed as soon as possible by oncological therapy, specially radiotherapy if needed.
    Neurocirugia (Asturias, Spain) 11/2011; 22(6):488-97. · 0.34 Impact Factor
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    ABSTRACT: Radiosurgery is among the treatment options for patients with vestibular schwannoma. We present the experience in our institution in the treatment of this disease with this technique. A retrospective study was made including 20 patients (11 women and 9 men; median age: 55.15 years-old) with vestibular schwannoma who received linear accelerator radiosurgery treatment since April 2005 until December 2008. Follow-up period was between 12 and 42 months, considering clinical examination of cranial nerves VII (House-Brackmann scale) and VIII (Gardner-Robertson scale) as well as radiological findings (considering tumor volume). For statistical analysis, the Fisher's exact test and logistic regression test were used. Certain worsening of hearing function was present in 25% of the patients. Five patients had large tumors at the moment of the treatment (equal or larger than 3.5 cm3), from which four deteriorated from headache, unsteady gait, dizziness/vertigo, facial numbness and tinnitus, with statistical significance (p < 0.05). From the first year of treatment on, there was a tumor volume decrease tendency, with no tumor growth in the medium/long term follow-up, achieving a local control rate of 100%. Radiosurgery has become an alternative in the treatment of patients with vestibular schwannoma of appropriate size, with high safety level, using low radiation doses, low rate of complications and good tumor control rate in the medium term follow-up.
    Revista de neurologia 03/2011; 52(5):275-82. · 1.18 Impact Factor
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    ABSTRACT: Skull defects and even meningeal defects are responsible for the majority of pneumocephalus cases. Sometimes, several factors can produce intracranial gas under pressure (tension pneumocephalus) with severe neurological impairment. We present a case of a 66 year old woman with a double ventriculo-peritoneal shunt that was admitted to the emergency service with an intracranial hypertension syndrome. A scalp wound was found on the physical examination and a brain CT showed a tension pneumocephalus. The scalp wound was just located on the border of a cranioplasty made after surgical removal of a parasagital meningioma eight years ago. Evacuation of pneumocephalus, reparation of cranial and meningeal defects and modification of factors contributing to the tension pneumocephalus (ventricular-peritoneal shunts programmed to low pressure) were performed. When we found a patient with a tension pneumocephalus we must think not only about a skull or meningeal defect but also look for other elements that produce gas inside skull under pressure (shunts, cerebrospinal fluid leak between others). Therefore, therapeutic approach has three parts: pneumocephalus drainage, to find and repair entrance of gas and to modify factors that turn pneumocephalus in a tension pneumocephalus.
    Neurocirugia (Asturias, Spain) 05/2009; 20(2):152-8. · 0.34 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Skull defects and even meningeal defects are responsible for the majority of pneumocephalus cases. Sometimes, several factors can produce intracranial gas under pressure (tension pneumocephalus) with severe neurological impairment. We present a case of a 66 year old woman with a double ventriculo-peritoneal shunt that was admitted to the emergency service with an intracranial hypertension syndrome. A scalp wound was found on the physical examination and a brain CT showed a tension pneumocephalus. The scalp wound was just located on the border of a cranioplasty made after surgical removal of a parasagital meningioma eight years ago. Evacuation of pneumocephalus, reparation of cranial and meningeal defects and modification of factors contributing to the tension pneumocephalus (ventricular-peritoneal shunts programmed to low pressure) were performed. When we found a patient with a tension pneumocephalus we must think not only about a skull or meningeal defect but also look for other elements that produce gas inside skull under pressure (shunts, cerebrospinal fluid leak between others). Therefore, therapeutic approach has three parts: pneumocephalus drainage, to find and repair entrance of gas and to modify factors that turn pneumocephalus in a tension pneumocephalus.
    Neurocirugia (Asturias, Spain) 01/2009; 20(2). · 0.34 Impact Factor
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    ABSTRACT: El neumoencéfalo se produce la mayoría de las veces por una solución de continuidad en el cráneo e incluso en las meninges. En ocasiones, ciertos factores pueden hacer que éste adopte las características de un neumoencéfalo a tensión provocando una clínica neurológica severa. Presentamos el caso de una paciente de 66 años portadora de una doble válvula de derivación ventrículo-peritoneal que acude a Urgencias con un cuadro de hipertensión intracraneal y que tras la exploración física y la tomografía computarizada se detecta una herida en cuero cabelludo y un neumoencéfalo a tensión. Este defecto en piel se hallaba justo en la zona del borde de una plastia craneal colocada tras la resección de un meningoma parasagital 8 años antes. Se realizó drenaje, reparación de la solución de continuidad y modificación de los factores que agravaban el cuadro del neumoencéfalo (la presencia de unas válvulas de derivación con presiones de salida muy bajas). La presencia de un neumoencéfalo a tensión debe hacernos pensar en encontrar no sólo el punto de acceso del aire al interior del cráneo sino también las causas que han favorecido que el neumoencéfalo adopte características de alta presión (sistemas de derivación o fístulas de LCR entre otros). De esta forma la orientación terapéutica adecuada tiene que ir destinada a la modificación de estos factores agravantes, además de hacia el drenaje del neumoencéfalo y cierre del defecto craneal.
    Neurocirugía: Organo oficial de la Sociedad Española de Neurocirugía, ISSN 1130-1473, Vol. 20, Nº. 2, 2009, pags. 152-158.
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    ABSTRACT: One of the therapeutic options for chronic adult hydrocephalus that has become widely used in our service is the lumboperitoneal shunt with low-pressure Spetzler catheter and in an outpatient regimen. We report on the first 30 patients treated in this way with a follow-up of between one and five years. Diagnosis was reached after studying the patient history and a clinical examination; Hakim and Adams' triad was found to be a primary and highly predictive factor, together with flow magnetic resonance imaging and the use of the ambulatory tap test. Patients who responded to the latter were submitted to placement of a shunt in a short operation performed with local anaesthetic and sedation. An evaluation of the three symptoms was carried out before and after the intervention according to a mixed scale (Rankin-Stein and Langfitt-Vall d'Hebron) and graphic tests based on the minimental test. At three months, 21 patients (70%) had improved and 14 of them (65%) maintained this improvement at three years; eight of these have been monitored for four and five years. Five patients died due to intercurrent illnesses. After comparing the complications that occurred with other case mixes involving both lumboperitoneal and ventriculoperitoneal shunts, we discuss the usefulness of this method (which is preferred by patients and relatives) in comparison to ventriculoperitoneal shunts, where the complications are more severe because they invade the brain and due to the need for general anaesthesia and longer hospitalisation. In addition, the method is more economical than the alternatives.
    Revista de neurologia 49(6):300-6. · 1.18 Impact Factor

Publication Stats

5 Citations
4.42 Total Impact Points

Institutions

  • 2009–2013
    • Consorcio Hospital General Universitario de Valencia
      Valenza, Valencia, Spain