Zoran Vucinovic

Klinički Bolnički Centar Split, Spalato, Splitsko-Dalmatinska, Croatia

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Publications (7)3.23 Total impact

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    ABSTRACT: Pseudocyesis is a rare condition in the pediatric population characterized by all signs and symptoms of pregnancy except the existence of a fetus [1]. In some patients it is associated with organic etiology, in others with mental disorders, also occurs in those without disorders in their medical history. Pseudocyesis occurs in both sexes, but more frequently in women. An effective treatment is a combination of psychotherapy and pharmacotherapy with antidepressants and antipsychotics [2]. We present a 15,9-year old girl with pseudocyesis as a cause of abdomen enlargement, who comes from an ordinary family with a negative history of psychiatric illness. The organic etiology of her condition was excluded, and therefore she was treated with antidepressants which contributed to the resolution of her case. KeywordsAbdomen enlargement–Adolescent–Pseudocyesis
    Central European Journal of Medicine 01/2011; 6(6):720-722. · 0.26 Impact Factor
  • Damir Roje, Zoran Vucinovic
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    ABSTRACT: Gestational diabetes mellitus (GDM) is a common pregnancy disorder. It is the result of inadequate insulin resistance regulation, a biological phenomenon usually accepted as a fact of unknown purpose. The regulation of insulin resistance, changes in the dynamics of quantitative and qualitative parameters of fetal growth, the onset of active fetal insulin secretion and clinical manifestation of GDM are too harmonized throughout pregnancy to be accidental. It is hypothesized that the origin of GDM, at least partially, might be explained by dissonance between the rapid lifestyle changes in the last decades/centuries and the Mother Nature inability to reprogram the physiologic processes, acquired long ago within such a ‘short time’. KeywordsGestational diabetes mellitus–Insulin resistance–Human placental lactogen
    Mediterranean Journal of Nutrition and Metabolism 01/2011; 4(2):153-154.
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    ABSTRACT: The aim of the study was to assess perinatal outcome of pregnancy burdened with maternal addiction in comparison with an unselected population from a European transition country. Data on pregnancies complicated by illicit drug abuse (n = 85) managed during a 10-year period (1997-2007) at Split University Hospital were analyzed. Data on the type of drug, course of gestation and labor, and on perinatal outcome were considered. Data on all non-dependence pregnancies recorded during the study period were used as a control group. During the study period, there were 85 dependence-complicated pregnancies (0.2%). Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%). Premature delivery was significantly more common in the group of pregnant addicts (21% vs. 6%); 49% of pregnant addicts were carriers of hepatitis C virus (HCV) and 14% of hepatitis B virus (HBV). Neonatal abstinence syndrome developed in 61 infants (7%) born to addicted mothers. There were 4 cases (4.6%) of early neonatal death; 7 neonates had 5-minute Apgar score < or = 7 (8%); 29 neonates had low birth weight for age (33%); and 7 neonates had congenital anomalies (8%). The risk of various congenital anomalies was 3-fold in the group of children born to addicted mothers. Addiction pregnancies present a small but high-risk group according to perinatal outcome. Appropriate obstetric and neonatal care can reduce the rate of complications in these pregnancies and improve perinatal outcome.
    Yonsei Medical Journal 10/2008; 49(5):705-13. · 1.31 Impact Factor
  • Edited by Deni Karelović, 01/2008; University hospital center Split., ISBN: 978-953-55167-1-2
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    ABSTRACT: There are conflicting data about gender differences in short-term mortality after acute myocardial infarction (AMI) after adjusting for age and other prognostic factors. Therefore, we investigated the risk profile, clinical presentation, in-hospital mortality and mechanisms of death in women and men after the first AMI. The data were obtained from a chart review of 3382 consecutive patients, 1184 (35%) women (69.7+/-10.9 years) and 2198 (65%) men (63.5+/-11.8 years) with a first AMI. The effect of gender and its interaction with age, risk factors and thrombolytic therapy on overall mortality and mechanisms of death were examined using logistic regression. Unadjusted in-hospital mortality was higher in women (OR 1.77, 95% CI 1.47-2.15). Adjustment that included both age only and age and other baseline differences (hypertension, diabetes mellitus, hypercholesterolemia, smoking, AMI type, AMI site, mean peak CK value, thrombolytic therapy) decreased the magnitude of the relative risk of women to men but did not eliminate it (OR 1.26, 95% CI 1.03-1.54 and OR 1.31 95% CI 1.03-1.66, respectively). Multivariate analysis revealed that female gender was an independent predictor of in-hospital mortality after the first AMI. Women were dying more often because of mechanical complications - refractory pulmonary edema and cardiogenic shock (P=0.02) or electromechanical dissociation (P=0.03), and men were dying mostly by arrhythmic death, primary ventricular tachycardia/fibrillation (P=0.002). Female gender was independently associated with mechanical death (OR 1.56, 95% CI 1.35-2.58; P=0.01) and anterior AMI was independently associated with arrhythmic death (OR 0.54, 95% CI 0.34-0.86; P=0.01). Our results demonstrate significant differences in mechanisms of in-hospital death after the first AMI in women and men, suggesting the possibility that higher in-hospital mortality in women exists primarily because of the postponing AMI death due to the gender-related differences in susceptibility to cardiac arrhythmias following acute coronary events.
    Annals of Saudi medicine 01/2006; 26(6):455-60. · 1.10 Impact Factor
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    ABSTRACT: A grave form of HDN (haemolytic disease of the new-born) is described in female twins, caused by Kell, E and Vel isoimmunisation. The weakly vital and anaemic new-born babies were hospitalised with signs of respiratory distress on the first day of their life after the delivery by Caesarean section in the 38 (th) week of pregnancy in the General Hospital Dubrovnik. Already during the first hours of their life jaundice developed with a high bilirubin level for their age. The direct Coombs' test on the twins and the indirect Coombs' test on the mother were positive. Immuno-haematological analysis proved the presence of anti-Kell, anti-E and the very rare anti-Vel antibodies in the mother's serum and in the plasma of both twins. We had no possibility to obtain appropriate blood for the indicated exsanguine transfusion because cross-probes with the accessible blood samples were positive. Up to the fourteenth day of life the anaemia deepened and was aggravated in one twin, the Kell positive one (phenotype CcDEe,Kk) in relation to the other, the Kell negative (phenotype CcDEe,kk) twin. The recovery of the female twins started on the 15 (th) day of life, after the transfusion of blood (phenotype: 0,ccddee, Vel negative, Kel negative), received from the bank of rare blood groups in London. This is the first described case of haemolytic disease of the new-born caused by antibodies on the antigen Kell, E and Vel. The low frequency of immunisation with rare antigens such as Kell, E and Vel, does not exclude the possibility of the occurrence of grave forms of haemolytic disease. All pregnant women with a positive indirect Coombs' test should be further immuno-haematologically tested in order to identify the antibodies type so that the treatment of the new-borns could be commenced in time.
    Zeitschrift für Geburtshilfe und Neonatologie 11/2004; 208(5):197-202. · 0.56 Impact Factor
  • Zeitschrift Fur Geburtshilfe Und Neonatologie - Z GEBURTSH NEONATOLOGIE. 01/2004; 208(5):197-202.

Publication Stats

34 Citations
3.23 Total Impact Points

Institutions

  • 2011
    • Klinički Bolnički Centar Split
      Spalato, Splitsko-Dalmatinska, Croatia
  • 2006
    • University of Split-School of Medicine
      Spalato, Splitsko-Dalmatinska, Croatia
  • 2004
    • University of Split
      Spalato, Splitsko-Dalmatinska, Croatia