Shih-Liang Hsieh

Publications (2)3.27 Total impact

• Conference Proceeding: An integrated photolithography system framework for automatic manufacturing in mass production 300mm Fab

  Yung-Yao Lee, Cheng-Fa Lin, Pi-Min Hsu, Kai-Wen Lo, Mei-Fang Hsu, Shih-Liang Hsieh
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  ABSTRACT: This paper describe an integration solution to achieve automatic manufacturing in the photolithography area of ProMOS's 300 mm fabrication facilities. An automation integration system framework that unifies automation system, photolithography systems and production control mechanisms, is developed to fulfill the factory level of mechanical automation dispatching in the 300 mm Fab, leading to continuous and uninterrupted processing. The pervasive use of automatic manufacturing direct operating costs, factory efficiency, simplifies production control, and caters internal/external customer demands.
  Semiconductor Manufacturing, 2007. ISSM 2007. International Symposium on; 11/2007
• Article: Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma.

  Kwan-Hwa Chi, Shih-Jen Liu, Chung-Pin Li, Hsu-Ping Kuo, Yu-Shan Wang, Yee Chao, Shih-Liang Hsieh
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  ABSTRACT: A phase 1 study was conducted to assess the safety and immunologic response induced by direct injection of autologous immature dendritic cells (DCs) into tumor under radiotherapy in advanced hepatoma patients. Patients with advanced/metastatic stage hepatoma not suitable for surgery or transarterial embolization were enrolled. Groups of patients received two vaccinations. Each vaccination consisted of intratumoral injections of autologous immature DCs in four dose cohorts of 5 x 10(6), 1.5 x 10(7), 3 x 10(7), and 5 x 10(7) cells 2 days after a single fraction of conformal radiotherapy of 8 Gy. The second vaccination was performed 3 weeks later. Of the 14 patients entered, 12 completed two cycles of vaccination. The treatment was well tolerated at any of the dose levels. Six patients had mild transient fever (grade 1-2) with chill reactions, three patients developed grade 1 fatigue, and one patient developed mild myalgia and arthralgia after DC injections. There was no evidence of clinically manifested autoimmune disease. There were two partial responses and four minor responses. A decrease in the alpha-fetoprotein (AFP) level of more than 50% was found in three patients. Ten patients had completed immunologic response evaluation 2 weeks after the second cycle of vaccination. The AFP-specific immune response was evident in eight patients examined by cytokine release assay and in seven patients by ELISPOT assay. Six patients showed an increased NK cell cytotoxic activity after vaccination. These data suggest that the combination of intratumoral injection of DCs and conformal radiotherapy is safe and can induce tumor-specific and innate immunity.
  Journla of Immunotherapy 02/2005; 28(2):129-35. · 3.27 Impact Factor