Caroline Fife

Publications (4)12.72 Total impact

• Article: Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006.

  Sharon R Hymes, Eric A Strom, Caroline Fife
  Journal of the American Academy of Dermatology 02/2006; 54(1):28-46. · 3.99 Impact Factor
• Article: Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study.

  Caroline Fife, Jon T Mader, Jeffery Stone, Leon Brill, Kathleen Satterfield, Andrea Norfleet, Amber Zwernemann, James T Ryaby, Darrell H Carney
  [show abstract] [hide abstract]
  ABSTRACT: Thrombin and thrombin peptides play a role in initiating tissue repair. The potential safety and efficacy of TP508 (Chrysalin) treatment of diabetic foot ulcers was evaluated in a 60-subject, prospective, randomized, double-blind, placebo-controlled phase I/II clinical trial. Chrysalin in saline or saline alone was applied topically, twice weekly, to diabetic ulcers with standardized care and offloading. A dose-dependent effect was seen in the per-protocol population where 1 and 10 mug Chrysalin treatment resulted in 45 and 72% more subjects with complete healing than placebo treatment. Chrysalin treatment of foot ulcers more than doubled the incidence of complete healing (p<0.05), increased mean closure rate approximately 80% (p<0.05), and decreased the median time to 100% closure by approximately 40% (p<0.05). Chrysalin treatment of heel ulcers within this population resulted in mean closure rates 165% higher than placebos (p<0.02) and complete healing in 86% (6/7) of ulcers compared with 0% (0/5) of placebo ulcers (p<0.03). Local wound reactions and adverse events (AEs) were equal between groups with no reported drug-related changes in laboratory tests or serious AEs. These results indicate the potential safety and efficacy of Chrysalin for treatment of diabetic foot ulcers.
  Wound Repair and Regeneration 15(1):23-34. · 2.91 Impact Factor
• Article: Guidelines for the prevention of lower extremity arterial ulcers.

  Harriet W Hopf, Cristiane Ueno, Rummana Aslam, Alan Dardik, Caroline Fife, Lynne Grant, Allen Holloway, Mark D Iafrati, Bruce Misare, Noah Rosen, Dag Shapshak, J Benjamin Slade, Judith West, Adrian Barbul
  Wound Repair and Regeneration 16(2):175-88. · 2.91 Impact Factor
• Article: Guidelines for the treatment of arterial insufficiency ulcers.

  Harriet W Hopf, Cristiane Ueno, Rummana Aslam, Kevin Burnand, Caroline Fife, Lynne Grant, Allen Holloway, Mark D Iafrati, Raj Mani, Bruce Misare, Noah Rosen, Dag Shapshak, J Benjamin Slade, Judith West, Adrian Barbul
  Wound Repair and Regeneration 14(6):693-710. · 2.91 Impact Factor