Pankaj Chaturvedi

Publications (2)6.29 Total impact

• Source

  Available from: Vanda Stepanek

  Article: Evaluation of a low-cost, portable imaging system for early detection of oral cancer.

  Mohammed S Rahman, Nilesh Ingole, Darren Roblyer, Vanda Stepanek, Rebecca Richards-Kortum, Ann Gillenwater, Surendra Shastri, Pankaj Chaturvedi
  [show abstract] [hide abstract]
  ABSTRACT: There is an important global need to improve early detection of oral cancer. Recent reports suggest that optical imaging technologies can aid in the identification of neoplastic lesions in the oral cavity; however, there is little data evaluating the use of optical imaging modalities in resource limited settings where oral cancer impacts patients disproportionately. In this article, we evaluate a simple, low-cost optical imaging system that is designed for early detection of oral cancer in resource limited settings. We report results of a clinical study conducted at Tata Memorial Hospital (TMH) in Mumbai, India using this system as a tool to improve detection of oral cancer and its precursors. Reflectance images with white light illumination and fluorescence images with 455 nm excitation were obtained from 261 sites in the oral cavity from 76 patients and 90 sites in the oral cavity from 33 normal volunteers. Quantitative image features were used to develop classification algorithms to identify neoplastic tissue, using clinical diagnosis of expert observers as the gold standard. Using the ratio of red to green autofluorescence, the algorithm identified tissues judged clinically to be cancer or clinically suspicious for neoplasia with a sensitivity of 90% and a specificity of 87%. Results suggest that the performance of this simple, objective low-cost system has potential to improve oral screening efforts, especially in low-resource settings.
  Head & Neck Oncology 01/2010; 2:10. · 3.13 Impact Factor
• Article: Low-cost, multimodal, portable screening system for early detection of oral cancer.

  Mohammed Rahman, Pankaj Chaturvedi, Ann M Gillenwater, Rebecca Richards-Kortum
  [show abstract] [hide abstract]
  ABSTRACT: Oral cancer is an important global health problem. There is an urgent need for improved methods to detect oral cancer and its precursors, because early detection is the best way to reduce oral cancer mortality and morbidity. In this work, we describe simple modifications to a surgical headlight system that enables direct visualization and digital image acquisition from oral tissue in multiple imaging modalities including fluorescence, white-light reflectance, and orthogonal polarization reflectance. Images obtained with the system in-vivo demonstrate that it is an attractive technology to explore for oral cancer screening in low-resource environments where clinical expertise is often unavailable.
  Journal of Biomedical Optics 13(3):030502. · 3.16 Impact Factor