Tatiani Uceli Maioli

Publications (2)11.83 Total impact

• Article: Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice.

  Yaron Ilan, Ruth Maron, Ann-Marcia Tukpah, Tatiani Uceli Maioli, Gopal Murugaiyan, Kaiyong Yang, Henry Yim Wu, Howard L Weiner
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  ABSTRACT: Leptin-deficient ob/ob mice are overweight, develop insulin resistance, and serve as a model for type 2 diabetes (T2D). Studies suggest that inflammatory pathways are linked to the development of insulin resistance and T2D both in animals and humans. We asked whether the induction of regulatory T cells (Tregs) could alleviate the pathological and metabolic abnormalities in ob/ob mice. We induced TGF-beta-dependent CD4(+) latency-associated peptide (LAP)-positive Tregs by oral administration of anti-CD3 antibody plus beta-glucosylceramide. We found a decrease in pancreatic islet cell hyperplasia, fat accumulation in the liver, and inflammation in adipose tissue, accompanied by lower blood glucose and liver enzymes. In addition, treated animals had decreased CD11b(+)F4/80(+) macrophages and TNF-alpha in adipose tissue. Adoptive transfer of orally induced CD4(+)LAP(+) Tregs ameliorated metabolic and cytokine abnormalities. Our results demonstrate the importance of inflammation in T2D and identify a unique immunological approach for treatment of T2D by the induction of Tregs.
  Proceedings of the National Academy of Sciences 05/2010; 107(21):9765-70. · 9.68 Impact Factor
• Source

  Available from: Rosa Maria Esteves Arantes

  Article: Immune response induced by New World Leishmania species in C57BL/6 mice.

  Tatiani Uceli Maioli, Erica Takane, Rosa Maria Esteves Arantes, Juliana Lopes Rangel Fietto, Luís Carlos Crocco Afonso
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  ABSTRACT: In the present study, C57BL/6 mice were inoculated with metacyclic Leishmania amazonensis or L. braziliensis promastigotes. While these animals were capable of controlling the infection by L. braziliensis, they developed chronic lesions with elevated numbers of parasites when infected by L. amazonensis. The differences in parasite control were associated with a decreased production of IFN-gamma and TNF by lymph node cells from L. amazonensis-infected mice. Furthermore, these animals presented decreased spleen cell proliferation and activation of germinal centers. In addition, we compared the ability of these parasites to hydrolyze extracellular ATP and AMP. While the ATPase activity of both parasite species was similar, L. amazonensis promastigotes presented higher AMP hydrolytic activity. This increased activity may lead to an increased production of adenosine, which has been shown to present anti-inflammatory activity and may thus be involved in the establishment of the immunosuppression observed in mice infected by L. amazonensis.
  Parasitology Research 11/2004; 94(3):207-12. · 2.15 Impact Factor