Publications (4)12.27 Total impact
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Article: The Risk of Epilepsy Following Febrile Convulsions.
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ABSTRACT: Neurology 1979;29:297-303.Neurology 06/2011; 76(23):1995. · 8.31 Impact Factor -
Article: Remission of Seizures and Relapse in Patients with Epilepsy
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ABSTRACT: In a longitudinal study of patients with epilepsy in Rochester, Minnesota, we found that the probability of being in remission (at least 5 consecutive years seizure-free, and continuing) at 20 years after diagnosis was 70%. The rates for remission we encountered were generally higher than those previously reported. We believe that the better prognosis in our series results from inclusion of all incidence cases in a defined population, beginning at the initial diagnosis of epilepsy. Prognosis for remission of epilepsy is poor in patients with' associated neurologic dysfunction identified from birth. Patients with idiopathic seizures and survivors of postnatally acquired epilepsy have better prospects for eventual remission. The probability of remission is highest in patients with generalized-onset seizures diagnosed before 10 years of age. Prognosis is less favorable for those with partial complex seizures and adult-onset epilepsy.RÉSUMÉA L'occasion d'une étude longitudinale des malades Épileptiques de Rochester (Minesota) nous avons trouvé que la probabilityé d'une remission (au moins 5 années consécutives sans crises) 20 années après le diagnostic était de 70%. Ce taux est plus élevé que ceux précédemment rapportés. Nous pensons que le meilleurs pronostic dans notre série tient à ce que nous avons inclus tous les cas incidents dans une population définie, à partir du diagnostic initial d'épilepsie. Le pronostic concernant la rémission est moins bon pour les patients qui présentent des troubles neurologiques associés d'origine obstétricale; il est meilleurs pour les patientsavec des crises idiopathiques ou ayant une épilepsie acquise après la naissance. Ce pronostic est le meilleur pour les malades qui présentent des crises généralisées d'emblée diagnostiquées avant L';áge de 10 ans; il est moins favorables chez ceux qui présentent des crises partielles à sémiologie complexe et chez ceux dont L';épilepsie est survenue à L';áge adulte.RESUMENEn un estudio longitudinal de enfermos con epilepsia realizado en Rochester, Minnesota, encontramos que la probabilidad de estar en remisión (por lo menos 5 años consecutivos sin ataques y continuar así), 20 años después del diagnóstico, era de un 70%. Las cifras de remisiones son generalmente más elevadas que las publicadas previamente. Pensamos que el mejor pronóstico de nuestras series se basa en la inclusión de todos los casos que inciden en una población definida desde el momento del diagnóstico de epilepsyía. El pronóstico con respecto a la remisión de la epilepsyía es pobre en los pacientes con disfunción neurológica asociada identificada desde el nacimiento. Tienen mejor posibilidad de eventual remisión aquellos enfermos con ataques idiopáticos y los supervivientes de epilepsyía adquirida en el periodo postnatal. La mayor posibilidad de remisión la tienen los enfermós con ataques de comienzo generalizado diagnósticados antes de los 10 años. El pronóstico es menos favorable en los que presentan ataques parciales complejos y epilepsyía de comienzo en edad adulta.ZUSAMMENFASSUNGIn einer Langzeitstudie überPatienten mit Epilepsie in Rochester, Minnesota, fander wir daß die Wahrs-cheinlichkeit einer Remission (mindestens 5 und mehr Jahre Anfallsfreiheit) 20 Jahre nach der Diagnosestel-lung bei 70% lag. Die Remissionsrate lag allgemein höher als in früheren Arbeiten angegeben wird. Wir glauben, daß die bessere Prognose in unserer Gruppe dadurch zustande kommt, daß, bei einer definierten Population, alle Falle mit dem Zeitpunkt der Diagnos-estellung Epilepsie in die Studie aufgenommen wur-den. Die Prognose bzgl. Anfallsfreiheit ist schlecht bei Patienten mit zusätzlich neurologischen Störungen, die seit Geburt bestehen. Sie ist besser bei Patienten mit idiopathischen Anfällen und bei über-lebenden einer postnatal erworbenen Epilepsie. Die Wahrscheinlichkeit einer Remission ist besonders hoch bei Patienten mit generalisierten Anfällen, die vor dem 10. Lebensjahr diagnostiziert wurden. Weni-ger günstig ist die Prognose bei Patienten mit parti-ellen Anfällen mit komplexer Symptomatik und Beginn im Erwachsenenalter.Epilepsia 11/1979; 20(6):729 - 737. · 3.96 Impact Factor -
Article: Congenital Malformations and Seizure Disorders in the Offspring of Parents with Epilepsy
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ABSTRACT: The medical records linkage system of the Rochester Project at the Mayo Clinic was used to identify births at Rochester hospitals from 1922 through 1976 to women with epilepsy and to the wives of men with epilepsy. The children were followed up to determine the incidence of congenital malformation and seizure disorders among them. In 133 births to women before the onset or after the remission of epilepsy, there were no major malformations. Among children born to mothers who had active epilepsy but did not take anticonvulsants during pregnancy, the rate of malformations was not excessive (2/82, or 2.4 per cent). Children of mothers who took anticonvulsants during pregnancy had a high incidence of major congenital malformations (19/177, or 10.7 per cent). Only certain types of malformations were elevated in the offspring of women taking anticonvulsants; these were congenital heart disease, cleft lip or palate, and, perhaps, ureteral duplication. The rate of congenital malformations among the children of men with epilepsy did not appear elevated: 9 in 234 (3.8 per cent) had major malformations. Although a strong association between maternal anticonvulsant medication for epilepsy and certain types of malformations was demonstrated, it is still possible that the association could be due, in part, to the epilepsy per se rather than to the anticonvulsants. The incidence of epilepsy was found to be 3.2 times higher than expected in children of women with epilepsy but was not increased in children of men with epilepsy. This difference does not seem to be due to maternal use of anticonvulsants or seizures during pregnancy. -
Article: Epidemiologic aspects of Hashimoto's thyroiditis and Graves' disease in rochester, minnesota (1935–1967), with special reference to temporal trends
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ABSTRACT: To evaluate the trends relative to incidence of Hashimoto's thyroiditis and Graves' disease from 1935 through 1967, records of all diagnosed cases occurring in residents of Rochester, Minnesota, were identified through the facilities of the Rochester-Olmsted County epidemiologic program. During those 33 yr, 246 cases of Hashimoto's thyroiditis and 256 cases of Graves' disease were diagnosed in the subject population. The average annual incidence rates per 100,000 for Hashimoto's thyroiditis for females increased from 6.5 (1935–1944) to 21.4 (1945–1954) to 67.0 (1955–1964) to 69.0 (1965–1967). There was no indication that the incidence of Graves' disease changed in any significant or consistent pattern during the 33 yr. The average annual rate for females was 36.8/100,000/yr for all age groups; the rate was highest among women 20–39 yr old.Metabolism.
