Publications (2)0 Total impact
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芳行 神奈川,
伸哉 松本, 学 赤羽,
創一 小池,
健清 吉村,
博史 内,
増隆 古江,
知明 今村,
Yoshiyuki Kanagawa,
Shinya Matsumoto, [......],
Masutaka Furue,
Tomoaki Imamura,
ヨシユキ カナガワ,
シンヤ マツモト,
マナブ アカハネ,
ソウイチ コイケ,
タケスミ ヨシムラ,
ヒロシ ウチ,
マスタカ フルエ,
トモアキ イマムラ
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ABSTRACT: 特集号 油症とPCB及びダイオキシン関連化合物 研究報告第22集 責任編集者 古江増隆 The Twenty-second Reports of the Study on Yusho―PCBs and Dioxin-Related Compounds―Guest Editor Masutaka Furue [Background] Since 1968, when the Yusho poisoning incident occurred, annual physical, dermatological, dental, and ophthalmological and laboratory examinations, collectively called Yusho health checks, have been conducted for Yusho patients. The Yusho incident was a health hazard caused by intake of rice-bran oil contaminated with PCB and PeCDF ; therefore, since 2001 the levels of dioxins such as PeCDF in the blood have been measured in applicants. Here, we investigated correlations among findings from various medical examinations and those between those findings and PeCDF, PCB, and PCQ. [Patients and Methods] Subjects were Yusho patients who underwent Yusho annual health checks and had their levels of PeCDF measured between 2001 and 2004. The results of 4 years of health checks of those who underwent the health checks for 2 years or longer were aggregated to extract representative inspection items by principal component analysis. We also investigated the presence or absence of correlations among these items and PeCDF, PCB, and PCQ levels in blood. [Results] Using 49 variables extracted by principal component analysis as objective variables, we determined that there were correlations between the following combinations : arthralgia, A/G ratio and PeCDF level, ophthalmological symptoms such as excessive eye discharge and PCB level, and total cholesterol, inferior gingival pigmentation and PCQ level.
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学 赤羽,
伸哉 松本,
芳行 神奈川,
淳睦 梶原,
尊 戸髙,
博仙 平川,
創一 小池,
増隆 古江,
知明 今村,
Manabu Akahane, [......],
Tomoaki Imamura,
マナブ アカハネ,
シンヤ マツモト,
ヨシユキ カナガワ,
ジュンボク カジワラ,
タカシ トダカ,
ヒロノリ ヒラカワ,
ソウイチ コイケ,
マスタカ フルエ,
トモアキ イマムラ
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ABSTRACT: 特集号 油症とPCB及びダイオキシン関連化合物 研究報告第22集 責任編集者 古江増隆 The Twenty-second Reports of the Study on Yusho―PCBs and Dioxin-Related Compounds―Guest Editor Masutaka Furue The half-life of 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in the Yusho patients has been reported to be approximately seven years. In the present study, we estimated the half-life of PeCDF using data from the medical check-ups of more than 300 Yusho patients. We performed linear regression analysis with a binary logarithm of PeCDF blood level in Yusho patients as the dependent variable, and the measurement year as the independent variable. Our results showed that there were many patients who had shown no reduction of their blood PeCDF level for several years. This result contradicts the previously reported half-life period. Therefore, we believe that a more complicated excretion model needs to be established to explain the discrepancy we found. We hypothesized that there might be two mechanisms of PeCDF assimilation in human digestive tract. In the present study, we also used our hypothesis to simulate PeCDF excretion in Yusho patients.
