Ruth Harper

Publications (3)4.02 Total impact

• Article: The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMA I).

  Bryan Williams, Philippe Gosse, Linda Lowe, Ruth Harper
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  ABSTRACT: To compare the efficacy and safety of once-daily telmisartan and ramipril on blood pressure (BP) reductions during the last 6 h of the dosing interval. In a prospective, randomized, open-label, blinded-endpoint study using ambulatory BP monitoring, 801 patients with mild-to-moderate hypertension were randomly assigned to once-daily treatment with telmisartan 80 mg for 14 weeks or ramipril 5 mg for 8 weeks and then force titrated to ramipril 10 mg for the last 6 weeks. Primary endpoints were the reduction from baseline in the last 6-h mean ambulatory systolic BP (SBP) and diastolic BP (DBP). Secondary endpoints included changes in 24-h, morning, daytime and night-time mean ambulatory BP and ambulatory BP response rates. Telmisartan 80 mg produced greater reductions in the last 6-h mean ambulatory SBP and DBP compared with ramipril 5 mg (P < 0.0001) and 10 mg (P < 0.0001), and was superior to ramipril for all secondary ambulatory SBP and DBP endpoints (P < 0.05). Ambulatory BP response rates (24-h mean ambulatory SBP/DBP < 130/80 mmHg or reduction from baseline > or = 10 mmHg) were greater with telmisartan 80 mg (P < 0.01) than with ramipril 5 and 10 mg. Ramipril was associated with a higher incidence of treatment-related cough (5.7 versus 0.5% for telmisartan). Telmisartan was significantly more effective than ramipril in reducing BP throughout the 24-h dosing interval and particularly during the last 6 h, a time when patients appear to be at greatest risk of cerebro- and cardiovascular events. Both drugs were well tolerated, although ramipril was associated with a higher incidence of cough.
  Journal of Hypertension 01/2006; 24(1):193-200. · 4.02 Impact Factor
• Article: The effect of accounting for combinations on investor decisions /

  Bullard, Ruth Harper
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  ABSTRACT: Thesis--University of Texas at Austin. Vita. Includes bibliographical references (leaves [193]-202). Photocopy of typescript. Ann Arbor, Mich. : University Microfilms International, 1977. -- 22 cm.
• Article: Studies in the functioning of the royal prerogative in the reign of James I.

  Gottdiener, Ruth Harper
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  ABSTRACT: Thesis (Ph. D.)--New York University. Bibliography: leaves [186-187]. Photocopy.