[show abstract][hide abstract] ABSTRACT: Injectable scaffolds are a class of materials that stimulate the regeneration of functional tissue within the body. These materials are attracting interest in regenerative medicine because they allow tissue repair to occur after minimally invasive administration. From a chemistry perspective these materials present new challenges because they must convert from an injectable material to a solid or gel with appropriate kinetics and without damaging surrounding tissues. Furthermore, the material may have to carry living cells or sensitive drug molecules into the body. The demands placed on these materials have stimulated research into novel chemical and physical mechanisms of forming porous structures within aqueous conditions. This review examines the underlying chemistry of a number of classes of injectable scaffolds and sets out challenges for these materials in the future.
Chemistry of Materials 01/2012; 24:781-795. · 8.24 Impact Factor
[show abstract][hide abstract] ABSTRACT: Here, we report successful synthesis of novel hyperbranched polymers with both thermal-responsive and photocrosslinkable properties via one-pot deactivation enhanced living polymerisations, including deactivation enhanced atom transfer radical polymerisation (DE-ATRP) 37 and 38 and deactivation enhanced reversible addition-fragmentation chain transfer polymerisation (DE-RAFT) .
Journal of Controlled Release - J CONTROL RELEASE. 01/2008; 132(3).