Peter W Daniels

Publications (4)14.68 Total impact

• Article: Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding.

  John Bingham, Diane J Green, Sue Lowther, Jessica Klippel, Simon Burggraaf, Danielle E Anderson, Hendra Wibawa, Dong Manh Hoa, Ngo Thanh Long, Pham Phong Vu, Deborah J Middleton, Peter W Daniels
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  ABSTRACT: Pekin ducks were infected by the mucosal route (oral, nasal, ocular) with one of two strains of Eurasian lineage H5N1 highly pathogenic avian influenza virus: A/Muscovy duck/Vietnam/453/2004 and A/duck/Indramayu/BBVW/109/2006 (from Indonesia). Ducks were killed humanely on days 1, 2, 3, 5 and 7 after challenge, or whenever morbidity was severe enough to justify euthanasia. Morbidity was recorded by observation of clinical signs and cloacal temperatures; the disease was characterized by histopathology; tissue tropism was studied by immunohistochemistry and virus titration on tissue samples; and viral shedding patterns were determined by virus isolation and titration of oral and cloacal swabs. The Vietnamese strain caused severe morbidity with fever and depression; the Indonesian strain caused only transient fever. Both viruses had a predilection for a similar range of tissue types, but the quantity of tissue antigen and tissue virus titres were considerably higher with the Vietnamese strain. The Vietnamese strain caused severe myocarditis and skeletal myositis; both strains caused non-suppurative encephalitis and a range of other inflammatory reactions of varying severity. The principal epithelial tissue infected was that of the air sacs, but antigen was not abundant. Epithelium of the turbinates, trachea and bronchi had only rare infection with virus. Virus was shed from both the oral and cloacal routes; it was first detected 24 h after challenge and persisted until day 5 after challenge. The higher prevalence of virus from swabs from ducks infected with the Vietnamese strain indicates that this strain may be more adapted to ducks than the Indonesia strain.
  Avian Pathology 08/2009; 38(4):267-78. · 1.71 Impact Factor
• Article: Emerging viruses: coming in on a wrinkled wing and a prayer.

  Kim Halpin, Alexander D Hyatt, Raina K Plowright, Jonathan H Epstein, Peter Daszak, Hume E Field, Linfa Wang, Peter W Daniels
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  ABSTRACT: The role that bats have played in the emergence of several new infectious diseases has been under review. Bats have been identified as the reservoir hosts of newly emergent viruses such as Nipah virus, Hendra virus, and severe acute respiratory syndrome-like coronaviruses. This article expands on recent findings about bats and viruses and their relevance to human infections. It briefly reviews the history of chiropteran viruses and discusses their emergence in the context of geography, phylogeny, and ecology. The public health and trade impacts of several outbreaks are also discussed. Finally, we attempt to predict where, when, and why we may see the emergence of new chiropteran viruses.
  Clinical Infectious Diseases 04/2007; 44(5):711-7. · 9.15 Impact Factor
• Article: Menangle and Nipah virus infections of pigs.

  Peter D Kirkland, Peter W Daniels, Mohd Nordin bin Mohd Nor, Robert J Love, Adrian W Philbey, Anthony D Ross
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  ABSTRACT: Viruses belonging to the family Paramyxoviridae generally have not been recognized as a significant cause of disease in pigs until recently. Between 1997 and 1999, there were large outbreaks of disease in pigs in Australia and Malaysia due to infection with viruses that have been shown to be new members of the Paramyxoviridae family. This article reviews current knowledge of Menangle and Nipah virus infections in pigs, the only major species of domestic animals to experience serious disease after infection with these viruses.
  Veterinary Clinics of North America Food Animal Practice 12/2002; 18(3):557-71, ix. · 1.47 Impact Factor
• Article: Serological evidence for Japanese encephalitis and West Nile viruses in domestic animals of Nepal.

  Ganesh Raj Pant, Ross A Lunt, Chris L Rootes, Peter W Daniels
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  ABSTRACT: A regional survey was conducted in Nepal for antibody to Japanese encephalitis virus (JEV) in domestic animals. Sera from pigs, and limited numbers of ducks and horses were collected from 16 districts in 2002-2003 and subjected to three serological tests. Of 270 porcine sera tested by C-ELISA, 55% were found positive for the presence of antibodies against Japanese encephalitis virus. Additional testing for IgM antibody to JEV revealed less than 2% of C-ELISA positive sera had evidence of recent JEV infection. Plaque reduction neutralisation tests (PRNT) using JEV, Murray Valley encephalitis (MVEV) and Kunjin (KUNV) viruses implicated JEV as the flavivirus associated with the observed antibody response in most sero-positive pigs. However, eight porcine sera with predominant neutralising antibody for KUNV (an Australasian subtype of West Nile Virus) provided evidence for the circulation of West Nile virus in Nepal.
  Comparative Immunology Microbiology and Infectious Diseases 29(2-3):166-75. · 2.34 Impact Factor