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Publications (2)0 Total impact

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    ABSTRACT: We present an autopsy case of 30-day-old female infant who had hidrotic ectodermal dyplasia with ichthyosiform erythroderma-like skin changes and low value of migration test of neutrophils. At the time of birth she had the abscence of hairs, eyelashes, eyebrows, dystrophic nails, erythema and hyperkeratosis with scales on whole body. Autopsy revealed the presence of eccrine glands and hyperkeratosis of the epidermis, thymic involution and papillary proliferation of squamous epithelium in esophagus and vagina. Aspiration pneumonia is the immediate cause of her death. The co-existence of ectodermal dysplasia and ichthyosiform-skin changes in this case provide an opportunity to study the relationship between congenital dysplasia and ichthyosiform erythroderma in their development. It might also be possible to correlate that relationship on common ground of immunological insufficiency
  • Kenji Kumagai, 謙治 熊谷
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    ABSTRACT: The pituitary gland, especially the corticotrophs, of spontaneously hypertensive rats (SHR) at 4 weeks (prehypertensive stage) and 10 weeks of age (early hypertensive stage) was examined immunohistochemically and morphometrically. The corticotrophs (ACTH positive stained cells) were found sparsely in the anterior lobe and a few cells were observed in the area adjacent to the intermediate lobe. The corticotrophs appeared small and stellate in shape and extended their cytoplasm to the neighboring sinusoid. The total area and number of the corticotrophs in SHR was significantly greater than that in WKY at 4 weeks of age. Although the total number of corticotrophs in SHR at 10 weeks was also greater, the total area of these cells was not different from that of WKY. The average width of the zona fasciculata and reticularis in SHR was significantly greater than that of WKY at 4 weeks. These result suggest that there was increased activity of the pituitary-adrenal system in SHR just before their spontaneously developing hypertension