Kenji Kumagai

Nagasaki University Hospital, Nagasaki, Nagasaki, Japan

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Publications (6)0 Total impact

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    ABSTRACT: We present here a rare autopsy case of malignant germ cell tumor with leukemia-like infiltration of the anterior mediastinum in a 35-year-old male. Chest X-rays revealed an abnormal mediastinum, which was diagnosed as thymoma. During the course of treatment, huge abnormal cells 40-50 mu in size were found in the peripheral blood smear and disseminated bone metastasis of the malignant thymoma was suspected. The tumor was resistant to both chemotherapy and radiotherapy. The patient died of respiratory failure. The autopsy disclosed a huge tumor measuring 24 X 13 X 10 cm in the anterior mediastinum. Histological findings of the tumor revealed cells which had spread to almost all organs, indicating leukemia-like infiltration. This pattern of metastasis has been reported in the cancer of non-hematologic origin under the term "carcinocythemia (CCA)". To our knowledge, the present case is the first report of a leukemia-like infiltration in case of malignant germ cell tumor. Careful serial section revealed no primary foci in either testis.
    Acta pathologica japonica 12/1985; 35(6):1561-70.
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    ABSTRACT: A case of myxopapillary ependymoma originating in the soft tissue is described. The tumor was located subcutaneously over the coccyx of an 11-year-old girl but was connected neither to the filum terminale nor cauda equina. Clinically, the tumor was locally resected with a diagnosis of pilonidal cyst. Histological and electron microscopic findings were identical to myxopapillary ependymoma. The tumor cells showed a positive reaction by immunoperoxidase method (PAP method) of glial fibrillary acidic protein (GFAP).
    Acta pathologica japonica 08/1985; 35(4):925-31.
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    ABSTRACT: A 47-year-old man, whose chief complaint was massive hematoemesis, was underwent partial gastrectomy. The resected stomach revealed a large elevated tumor, Borrmann I type, measuring 4 X 3 X 2 cm, in the anterior wall of the body. Histologically, the major part of the tumor showed a sarcomatous structure, while the margin and some areas consisted of papillary or well differentiated adenocarcinoma, invading to the submucosa. The border between the two components was irregular and the two components intermixed with each other in some areas. In the sarcomatous area, there was no bone, cartilage or muscle. It was interesting that the metastatic lymph nodes disclosed a sarcomatous picture with teratomatous pattern and that immunocytochemically HCG was localized in some of the adenocarcinoma in the lymph node.
    Gan no rinsho. Japan journal of cancer clinics 01/1985; 30(15):1931-6.
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    ABSTRACT: An 89-year-old woman with adenosquamous carcinoma arising in a dermoid cyst (benign cystic teratoma) of the ovary is reported. The malignant change of a dermoid cyst is rare. To our knowledge, this is the first report case of an adenosquamous carcinoma arising in a dermoid cyst of the ovary. Moreover, this case is the oldest patient on record. It is important that dermoid cyst be examined carefully.
    Gan no rinsho. Japan journal of cancer clinics 12/1984; 30(14):1840-4.
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    ABSTRACT: We present an autopsy case of 30-day-old female infant who had hidrotic ectodermal dyplasia with ichthyosiform erythroderma-like skin changes and low value of migration test of neutrophils. At the time of birth she had the abscence of hairs, eyelashes, eyebrows, dystrophic nails, erythema and hyperkeratosis with scales on whole body. Autopsy revealed the presence of eccrine glands and hyperkeratosis of the epidermis, thymic involution and papillary proliferation of squamous epithelium in esophagus and vagina. Aspiration pneumonia is the immediate cause of her death. The co-existence of ectodermal dysplasia and ichthyosiform-skin changes in this case provide an opportunity to study the relationship between congenital dysplasia and ichthyosiform erythroderma in their development. It might also be possible to correlate that relationship on common ground of immunological insufficiency
    01/1984;
  • Kenji Kumagai, 謙治 熊谷
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    ABSTRACT: The pituitary gland, especially the corticotrophs, of spontaneously hypertensive rats (SHR) at 4 weeks (prehypertensive stage) and 10 weeks of age (early hypertensive stage) was examined immunohistochemically and morphometrically. The corticotrophs (ACTH positive stained cells) were found sparsely in the anterior lobe and a few cells were observed in the area adjacent to the intermediate lobe. The corticotrophs appeared small and stellate in shape and extended their cytoplasm to the neighboring sinusoid. The total area and number of the corticotrophs in SHR was significantly greater than that in WKY at 4 weeks of age. Although the total number of corticotrophs in SHR at 10 weeks was also greater, the total area of these cells was not different from that of WKY. The average width of the zona fasciculata and reticularis in SHR was significantly greater than that of WKY at 4 weeks. These result suggest that there was increased activity of the pituitary-adrenal system in SHR just before their spontaneously developing hypertension