Ralf Sadurski

Publications (3)0 Total impact

• Article: Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals

  Franz-Josef Schmitz, Ralf Sadurski, Angela Kray, Mechthild Boos, Roland Geisel, Karl Köhrer, Jan Verhoef, Ad C Fluit
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  ABSTRACT: The polymerase chain reaction (PCR) was used to study the prevalence of the macrolide resistance genes ermA , ermB , ermC , msrA/msrB , ereA and ereB , in 851 clinical isolates of Staphylococcus aureus and 75 clinical isolates of Enterococcus faecium that were erythromycin resistant. The isolates were from 24 European university hospitals. In S. aureus , the ermA gene was more common in methicillin-resistant S. aureus (MRSA) isolates (88%) than in methicillin-susceptible S. aureus (MSSA) isolates (38%), and occurred mainly in strains with constitutive MLS B expression. In contrast, ermC was more common in MSSA (47%) than in MRSA (5%), occurring mainly in strains with inducible expression. The ereB gene was only found in MRSA isolates expressing a constitutive MLS B phenotype (1%). The ereA gene was not detected. Macrolide resistance by efflux due to the msrA / msrB gene was only detected in MSSA isolates (13%). In contrast to S. aureus , erythromycin resistance in E. faecium was almost exclusively due to the presence of the ermB gene (93%).
• Article: Cross-resistance analyses and molecular typing of Staphylococcus aureus and Streptococcus spp. isolates resistant to quinupristin/dalfopristin

  Franz-Josef Schmitz, Ralf Sadurski, Andre Stattfeld, Angela Kray, Jan Verhoef, A. C. Fluit
• Article: Resistance to tetracycline and distribution of tetracycline resistance genes in European Staphylococcus aureus isolates

  Franz-Josef Schmitz, Angela Krey, Ralf Sadurski, Jan Verhoef, Dana Milatovic, Ad C Fluit, for the European SENTRY participants