Angela McCann

Publications of Angela McCann

• The tree of genomes: An empirical comparison of genome phylogeny reconstruction methods.

  Authors: Angela McCann, James Cotton, James McInerney

  BMC evolutionary biology. 12/2008; 8(1):312.

  ABSTRACT: BACKGROUND: In the past decade or more, the emphasis for reconstructing species phylogenies has moved from the analysis of a single gene to the analysis of multiple genes and even completedABSTRACT: BACKGROUND: In the past decade or more, the emphasis for reconstructing species phylogenies has moved from the analysis of a single gene to the analysis of multiple genes and even completed genomes. The simplest method of scaling up is to use familiar analysis methods on a larger scale and this is the most popular approach. However, duplications and losses of genes along with horizontal gene transfer (HGT) can lead to a situation where there is only an indirect relationship between gene and genome phylogenies. In this study we examine five widely-used approaches and their variants to see if indeed they are more-or-less saying the same thing. In particular, we focus on Conditioned Reconstruction as it is a method that is designed to work well even if HGT is present. RESULTS: We confirm a previous suggestion that this method has a systematic bias. We show that no two methods produce the same results and most current methods of inferring genome phylogenies produce results that are significantly different to other methods. CONCLUSIONS: We conclude that genome phylogenies need to be interpreted differently, depending on the method used to construct them.

• The tree of genomes: An empirical comparison of genome-phylogeny reconstruction methods

  Authors: Angela McCann, James A Cotton, James O McInerney