Concepción Rodriguez-Esteban

Publications (5)42.86 Total impact

• Article: Wnt/beta-catenin signaling regulates vertebrate limb regeneration.

  Yasuhiko Kawakami, Concepción Rodriguez Esteban, Marina Raya, Hiroko Kawakami, Mercè Martí, Ilir Dubova, Juan Carlos Izpisúa Belmonte
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  ABSTRACT: The cellular and molecular bases allowing tissue regeneration are not well understood. By performing gain- and loss-of-function experiments of specific members of the Wnt pathway during appendage regeneration, we demonstrate that this pathway is not only necessary for regeneration to occur, but it is also able to promote regeneration in axolotl, Xenopus, and zebrafish. Furthermore, we show that changes in the spatiotemporal distribution of beta-catenin in the developing chick embryo elicit apical ectodermal ridge and limb regeneration in an organism previously thought not to regenerate. Our studies may provide valuable insights toward a better understanding of adult tissue regeneration.
  Genes & Development 01/2007; 20(23):3232-7. · 11.66 Impact Factor
• Source

  Available from: genepath.med.harvard.edu

  Article: Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud

  Mineko Kengaku, Javier Capdevila, Concepción Rodriguez-Esteban, Jennifer De La Peña, Randy L. Johnson, Juan Carlos Izpisúa Belmonte, Clifford J. Tabin
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  ABSTRACT: The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3ainduces ectopic expression of AER-specific genes in the limb ectoderm. The genes β-catenin and Lef1 can mimic the effect of Wnt3a, and blocking the intrinsic Lef1activity disrupts AER formation. Hence, Wnt3a functions in AER formation through the β-catenin/LEF1 pathway. In contrast, neither β-catenin nor Lef1 affects theWnt7a-regulated dorsoventral polarity of the limb. Thus, two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways.
  Science 05/1998; 280(5367):1274-1277. · 31.20 Impact Factor
• Article: Erratum: Radical fringe positions theapical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

  Concepción Rodriguez-Esteban, John W. R. Schwabe, Jennifer De La Peña, Bryon Foys, Brian Eshelman, Juan Carlos Izpisúa Belmonte
• Article: Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

  Daniel P. Szeto, Concepción Rodriguez-Esteban, Aimee K. Ryan, Shawn M. O'Connell, Forrest Liu, Chrissa Kioussi, Anatoli S. Gleiberman, Juan Carlos Izpisúa Belmonte, Michael G Rosenfeld
• Article: RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

  Ingolf Bach, Concepción Rodriguez-Esteban, Catherine Carrière, Anil Bhushan, Anna Krones, David W Rose, Christopher K Glass, Bogi Andersen, Juan Carlos Izpisúa Belmonte, Michael G Rosenfeld