Paolo Anselmo

Università degli Studi di Torino, Torino, Piedmont, Italy

Are you Paolo Anselmo?

Claim your profile

Publications (3)0 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Plasma azopigments derived from conjugated biirubin were analyzed by thin-layer chromatography according toHeirwegh et al.21, 23 in 14 cases of obstructive jaundice and in 11 of acute hepatitis. The chromatographic patterns were compared with those obtained from azopigments derived from 8 normal bile samples. The plasma pigment patterns did not differ from those of the bile in number and chromatographic mobility of the spots. However, the quantitative percentages of the plasma azopigments were significantly modified: the α0 fraction (free azodipyrrolic pigment) increased in both icteric syndromes, while the δ fraction (mainly glucuronide azopigment) decreased. Moreover, the behaviour of two closed components of the δ group showed significant differences in both icteric syndromes. It can be postulated that the synthesis of bilirubin diconjugates decreases both in hepatocellular and cholestatic jaundice, while monoglucuronidated as well as saccharide and glucoside conjugates increase. In cholestatic jaundice the conjugation with glucuronic acid mainly takes place in the normal way, whereas compounds with different features are formed in hepatitis.
    International Journal of Clinical & Laboratory Research 09/1979; 9(4):379-386.
  • Journal of Steroid Biochemistry. 01/1979; 11.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Plasma azopigments derived from conjugated bilirubin were analyzed by thin-layer chromatography according to HEIRWEGH et al. in 14 cases of obstructive jaundice and in 11 of acute hepatitis. The chromatographic patterns were compared with those obtained from azopigments derived from 8 normal bile samples. The plasma pigment patterns did not differ from those of the bile in number and chromatographic mobility of the spots. However, the quantitative percentages of the plasma azopigments were significantly modified: the alpha 0 fraction (free azodipyrrolic pigment) increased in both icteric syndromes, while the delta fraction (mainly glucuronide azopigment) decreased. Moreover, the behavior of two closed components of the delta group showed significant differences in both icteric syndromes. It can be postulated that the synthesis of bilirubin diconjugates decreases both in hepatocellular and cholestatic jaundice, while monoglucuronidated as well as saccharide and glucoside conjugates increase. In cholestatic jaundice the conjugation with glucuronic acid mainly takes place in the normal way, whereas compounds with different features are formed in hepatitis.
    La Ricerca in Clinica e in Laboratorio 9(4):379-86.