Hyun Joo Lee

Kyungpook National University Hospital, Sŏul, Seoul, South Korea

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Publications (130)330.25 Total impact

  • [show abstract] [hide abstract]
    ABSTRACT: Thyroid hormone signaling has long been implicated in mammalian testicular function, affecting steroidogenesis in testicular Leydig cells. However, its molecular mechanism is not well understood. Here, we investigated the molecular action of thyroid hormone receptor-alpha (TRα) on mouse testicular steroidogenesis. TRα/thyroid hormone (T3) signaling differentially affected the expression of steroidogenic enzyme genes, mainly regulating their promoter activity. TRα directly regulated the promoter activity of the P450c17 gene, elevating its expression in the presence of T3. TRα also indirectly regulated the expression of steroidogenic enzyme genes, such as steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD), by modulating the transactivation of Nur77 on steroidogenic enzyme gene promoters through protein-protein interaction. TRα enhanced Nur77 transactivation by excluding histone deacetylases from Nur77 in the absence of T3, while liganded TRα inhibited Nur77 transactivation, likely due to interfering with the recruitment of coactivator such as the steroid receptor coactivator-1 to Nur77. Together, these findings suggest a role of TRα/T3 in testicular steroidogenesis and may provide molecular mechanisms for the differential regulation of steroidogenic enzyme genes by thyroid hormone.
    Molecular Endocrinology 04/2014; · 4.75 Impact Factor
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    ABSTRACT: We presented two interesting cases of gastrocolocutaneous fistula that occurred after percutaneous endoscopic gastrostomy (PEG) tube placement, and its management. This fistula is a rare complication that occurs after PEG insertion, which is an epithelial connection between mucosa of the stomach, colon, and skin. The management of the fistula is controversial, ranging from conservative to surgical intervention. Endoscopists should be aware of the possibility of gastrocolocutaneous fistula after PEG insertion, and should evaluate the risk factors that may contribute to the development of gastrocolocutaneous fistula before the procedure. We reviewed complications of gastrostomy tube insertion, symptoms of gastrocolocutaneous fistula, and its risk factors. (Korean J Gastroenterol 2014;63:120-124).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 02/2014; 63(2):120-4.
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    ABSTRACT: The proximal ulna, particularly the course of the posterior border, has a complex three-dimensional (3D) morphology which has been highlighted recently due to its clinical relevance in relation to surgical treatments. 3D computed tomography (CT) reconstruction and computer-aided design (CAD) based software can help to visualize the complex anatomy and thus aid the investigation of the more detailed morphology of the proximal ulna. In our current study, 3D CT reconstruction images of 20 cadavers were imported into the 3D CAD program. Three morphologic angle parameters of the proximal ulna were measured including the dorsal, varus and torsion angulation. The torsion angulation was measured using the flat spot of olecranon dorsal aspect. We measured the total length of the ulna and the distance between the olecranon tip and the apex of dorsal and varus angulation. Furthermore, the thickness of olecranon was also measured for all the specimens. The results showed that the mean dorsal, varus, and torsion angulation was 4.3° (range 2.6°-5.9°), 12.1° (range 7.9°-17.6°), and 22.5° (range 16.6°-30.5°), respectively. The average length ratio of the dorsal and varus angulation apex to the total ulnar length was 26.4 % (range 19.8-30.7 %) and 32.7 % (range 27.5-37.5 %), respectively. The average of olecranon thickness at the proximal tip, mid-olecranon fossa, and at coronoid tip level was 17.8 mm (range 14.1-22.8 mm), 19.7 mm (range 15.8-23.1 mm), and 35.1 mm (range 27.9-41.8 mm), respectively. In conclusion, variations in the proximal ulna have to be considered when anatomically contoured dorsal plates are applied. Knowledge of the 3D morphologic anatomy of the proximal ulna would provide important information on fracture reductions, and the design of a precontoured dorsal plate or a prosthetic ulnar stem.
    Anatomia Clinica 02/2014; · 0.93 Impact Factor
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    ABSTRACT: Pulmonary sclerosing pneumocytoma is a rare, benign lung tumor that usually occurs in middle-aged women. It usually manifests as isolated pulmonary nodules and is often confused with other solitary, benign nodules. We present a case of sclerosing pneumocytoma with clustered lung nodules and surrounding ground-glass opacity in a single lobe in a young man. Progressive growth was seen on serial CT observations, and the nodules appeared similar to those seen in active pulmonary tuberculosis.
    Clinical imaging 01/2014; · 0.73 Impact Factor
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    ABSTRACT: Primary small intestinal lymphoma is relatively uncommon. Small bowel tumors are difficult to diagnose, because they are usually asymptomatic in the initial phase, and they are not easily detected by traditional methods of investigating the small intestine. This case shows a successfully detected and treated gastrointestinal bleeding from rare ileal mucosa-associated lymphoid tissue lymphoma, using double balloon endoscopy. (Korean J Gastroenterol 2013;62:365-369).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 12/2013; 62(6):365-9.
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    ABSTRACT: Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose and liver tissue, frequently involved in insulin resistance. 8-Oxo-2'-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages. In this study, we explored whether 8-Oxo-dG suppressed a series of systemic inflammatory cascades, resulting in the amelioration of typical features of metabolic syndrome in obese mice. The results demonstrate that 8-Oxo-dG effectively improved hyperglycemia, dyslipidemia and fatty liver changes in obese mice. The level of biochemical markers indicative of systemic inflammation were reduced in 8-Oxo-dG treated mice, whereas serum levels of adiponectin, a crucial factor associated with improved metabolic syndrome, were enhanced. Our results demonstrate that 8-Oxo-dG effectively disrupts the pathogenesis of insulin resistance and obesity-associated metabolic syndrome.
    Biochemical and Biophysical Research Communications 12/2013; · 2.41 Impact Factor
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    ABSTRACT: Osteosarcoma is the most common malignant bone tumor in children and adolescents. This aggressive cancer mostly occurs in the long bones. Therefore, novel therapeutic approaches, such as biological therapies and gene therapy, are required to efficiently treat osteosarcoma. Capsaicin (trans‑8‑methyl‑N‑vanillyl‑6‑nonenamide) has been demonstrated to inhibit the growth of several types of cancer cells and a number of studies have shown that osteosarcoma may be vulnerable to biological therapies. However, little is known regarding the therapeutic effects of capsaicin on osteosarcoma. This study investigated the effects of capsaicin on MG63 human osteosarcoma cells, in addition to elucidating the regulatory signaling pathways underlying the effects of capsaicin, the caspase cascade and the antioxidant enzyme system. The MG63 cell line was treated with various concentrations of capsaicin. Cells were analyzed using MTT and flow cytometry, and the presence of DNA fragmentation was evaluated using TUNEL assay. Results showed capsaicin induced apoptosis in MG63 cells. Thus, capsaicin exhibited an anticancer effect in osteosarcoma cells.
    Molecular Medicine Reports 12/2013; 8(6):1655-62. · 1.17 Impact Factor
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    ABSTRACT: Terlipressin is a vasopressin analogue that is widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has a lower incidence of severe ischemic complications than does vasopressin. However, it can still lead to serious complications such as myocardial infarction, skin necrosis, or bowel ischemia. Herein we report a case of severe ischemic bowel necrosis in a 46-year-old cirrhotic patient treated with terlipressin. Although the patient received bowel resection, death occurred due to ongoing hypotension and metabolic acidosis. Attention should be paid to patients complaining of abdominal pain during treatment with terlipressin.
    Clinical and molecular hepatology. 12/2013; 19(4):417-20.
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    ABSTRACT: Hemangiomas are vascular anomalies characterized by increased proliferation and turnover of endothelial cells. Hemangiomas of the parotid region are relatively uncommon in adult population, and there are a few reports of hemangioma with large phlebolith within the parotid gland. We herein report a case of it. Sialography may be a useful investigation method in the evaluation of radiopaque lesions localized intraglandularly in the parotid area to rule out the sialolith. Cavernous hemangioma with phleboliths should be included in the differential diagnosis of a swelling in the mandibular area.
    The Journal of craniofacial surgery 11/2013; 24(6):e621-3. · 0.81 Impact Factor
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    ABSTRACT: OBJECTIVE. We conducted a retrospective analysis to evaluate the diagnostic outcomes of CT-guided aspiration and core biopsy of 305 pulmonary nodules measuring less than 1 cm. MATERIALS AND METHODS. We determined the diagnostic yield of using CT-guided aspiration and core biopsy to analyze 305 lesions in 290 patients. Diagnostic performance was evaluated according to the biopsy method, including aspiration alone, core biopsy alone, and combination use, and the consistency of the nodule, including solid, partly solid ground-glass opacity (GGO), and pure GGO. Final diagnoses were established in 268 of the 305 lesions (87.9%). Nondiagnostic biopsy results were obtained for 27 of the 268 lesions (10.1%). RESULTS. The overall sensitivity, specificity, positive predictive value, and negative predictive value for the diagnosis of malignancy were 93.1% (148 of 159 lesions), 98.8% (81/82), 99.3% (148/149), and 88.0% (81/92), respectively; diagnostic accuracy was 95.0% (229/241). Using multivariate logistic regression analysis, we found that aspiration alone was a significant independent risk factor associated with diagnostic failure (odds ratio, 3.199; p = 0.001). CONCLUSION. The use of CT-guided aspiration and core biopsy resulted in a high diagnostic yield for pulmonary nodules smaller than 1 cm. The use of the aspiration method alone was an independent risk factor associated with diagnostic failure.
    American Journal of Roentgenology 11/2013; 201(5):964-70. · 2.90 Impact Factor
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    ABSTRACT: Gallbladder cancer, the most common biliary tract malignancy, is a highly malignant neoplasm. In the present work, we have analyzed the significance of cell cycle-related proteins to predict prognosis and to provide guidance for optimal therapeutic decision-making in patients with gallbladder adenocarcinoma. The expressions of p16, p21, p27, p53, p63, cyclin D1, bcl-2 and bcl-6 were examined in a tissue microarray constructed from 96 cases of gallbladder adenocarcinoma by immunohistochemistry and correlated with clinicopathologic prognostic factors. Expression of p16 was correlated with a low pT stage, adenoma background and good prognosis. Cases with p63 expression showed a higher T stage, more frequent perineural invasion and poor prognosis when compared to cases without p63 expression. Over-expression of p53 or loss of p53 was associated with poor tumor differentiation, frequent distant metastasis and low disease-specific survival rate. The expressions of p21, p27, bcl-2, bcl-6 and cyclin D1 were not significant prognostic factors for gallbladder adenocarcinoma. These results indicate that p16, p63 and p53 can be used as prognostic markers in gallbladder adenocarcinoma; especially p53 and p63 as poor prognostic markers and p16 as a favorable prognostic marker.
    Pathology & Oncology Research 11/2013; · 1.56 Impact Factor
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    ABSTRACT: The aim of this study was to characterize primary cells from extrauterine carcinosarcoma (CS) and to establish a primary CS xenograft mouse model. Primary cells were isolated from a patient with CS and cultured in vitro. Primary CS cells were verified for their ability to consecutively generate tumorigenesis in NOD/SCID mice. The properties of xenograft tumor and explants cells were investigated by immunohistochemistry, cytogenetic, and FACS analysis. Anticancer drug susceptibility of primary CS was analyzed using CCK-8. Primary CS cells greater than 27 passages in vitro showed an ability of a series of xenograft tumorigenesis in vivo having the same marker expression and cytogenetic character as that of original tumor. In addition, explants of xenograft tumors retained their original characteristics in the in vitro culture system. Finally, the analysis of the susceptibility to anticancer drug revealed that primary CS cells were susceptible to both doxorubicin and nilotinib, which are tyrosine kinase inhibitors. The primary CS cells and the primary CS xenograft tumorigenesis introduce a new therapeutic model for targeting cancer and also explore a deeper understanding of generation of the tumor itself.
    International Journal of Gynecological Cancer 11/2013; 23(9):1552-60. · 1.94 Impact Factor
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    ABSTRACT: Superior segmental optic hypoplasia (SSOH) is a congenital disorder that is expected not to progress. This study aimed to determine the prevalence and clinical characteristics of coexistent open-angle glaucoma (OAG) in patients with SSOH. We retrospectively reviewed the records of 61 patients diagnosed with SSOH. The estimated prevalence and clinical characteristics of concomitant OAG among patients with SSOH were investigated. Of the 61 patients with SSOH, 12 patients presented with concomitant OAG (mean age, 44.8±19.2 y). Mean follow-up period was 84.9±50.9 months. Five patients (8.2%) were diagnosed with both high-tension glaucoma (HTG) and SSOH; 4 had HTG and SSOH in both the eyes; and the other had HTG only in the eye with SSOH. Seven patients (11.5%) were diagnosed with both normal-tension glaucoma (NTG) and SSOH. Two patients had NTG and SSOH in both eyes and 5 patients had unilateral NTG. The estimated prevalence of OAG in patients with SSOH was 19.7% (95% confidence interval, 9.7%-29.7%). Primary OAG, including HTG and NTG, could develop in eyes with SSOH, regarded as having a nonprogressive visual field defect. The estimated prevalence of OAG, including both NTG and HTG, might be relatively higher in the SSOH patients. Thus, continuous follow-up examinations of patients with SSOH are required.
    Journal of glaucoma 06/2013; · 1.74 Impact Factor
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    ABSTRACT: Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition of angiogenesis and cell proliferation. However, the effects of Rg3 and its molecular mechanism on glioblastoma multiforme (GBM) remain unclear. Therefore, it is essential to develop a greater understanding of this novel compound. In the present study, we investigated the effects of Rg3 on a human glioblastoma cell line and its molecular signaling mechanism. The mechanisms of apoptosis by ginsenoside Rg3 were related with the MEK signaling pathway and reactive oxygen species. Our data suggest that ginsenoside Rg3 is a novel agent for the chemotherapy of GBM.
    Oncology Reports 06/2013; · 2.30 Impact Factor
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    ABSTRACT: The purpose of this study was to examine the anti-oxidative activity of pectin and other polysaccharides in order to develop a cosmeceutical base having anti-oxidative effects towards retinyl palmitate (RP). The anti-oxidative stabilizing effects of pectin and other polysaccharides on RP were evaluated by DPPH assay and then the stabilizing effect of pectin on RP was examined as a function of time. Among the polysaccharides we examined, pectin exhibited a considerably higher anti-oxidative activity, with an approximately 5-fold greater DPPH radical scavenging effect compared to other polysaccharides. The DPPH radical scavenging effect of pectin increased gradually with increasing concentrations of pectin. At two different RP concentrations, 0.01 and 0.1% in ethanol, addition of pectin improved the stability of RP in a concentration dependent manner. The stabilizing effect of pectin on RP was more effective for the lower concentration of RP (0.01%, v/v). Further, degradation of RP was reduced following the addition of pectin as measured over 8 hours. From the results obtained, it can be suggested that pectin may be a promising ingredient for cosmeceutical bases designed to stabilize RP or other pharmacological agents subject to degradation by oxidation.
    Korean Journal of Physiology and Pharmacology 06/2013; 17(3):197-201. · 1.00 Impact Factor
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    ABSTRACT: A sharp, impacted fish bone in the esophagus is an indication for urgent endoscopy. Endoscopic removal of such an object is a challenging task. An endoscopic protector hood is then used to remove the object. However, an endoscopic hood protector is not always available. In a patient with a large hiatal hernia, the protector hood may not return to the original shape when it passes through the gastroesophageal junction and therefore may not properly protect the esophageal mucosa from the sharp foreign body. In our case, it was impossible to deploy the endoscopic hood protector through the gastroesophageal junction despite multiple attempts. We propose an alternative solution for such cases. We safely removed a large sharp-edged flat fish bone that was folded and compressed using a detachable snare after releasing and pushing the fish bone into the stomach using an endoscope equipped with a transparent cap used for dilating the esophageal wall. This method of using an endoscopic cap and detachable snare is a safe, useful alternative for endoscopically removing a large sharp-edged flat foreign body from the upper gastrointestinal tract. This alternative technique has not been reported in the English medical literature. (Korean J Gastroenterol 2013;61:215-218).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 04/2013; 61(4):215-8.
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    ABSTRACT: BACKGROUND: This study is to evaluate the feasibility and safety of video-assisted thoracoscopic (VATS) lobectomy with two incisions. METHODS: A total of 73 patients (male 47, female 26; mean age 61.2 ± 12.00 years old) who underwent major pulmonary resection, through VATS, using two incisions were included in this study. The thoracoscopy port was placed at the 7th or the 8th intercostal space in the mid-axillary line, and the working port, 3~5 cm long, at the 5th intercostal space, on the operator's side. RESULTS: The preoperative diagnosis was benign lung disease in 8 patients (11.0%) and malignant lung disease in 65 (89.0%). Two patients (3.1%) needed a third port during surgery due to severe pleural adhesion, and conversion to thoracotomy was needed in 5 (6.8%), due to bleeding at pulmonary arterial branch (n = 3), anthracofibrotic lymph nodes around pulmonary artery (n = 1), and severe pleural adhesion (n = 1). The mean duration of the operation in the 66 patients, completed by a two-incision VATS lobectomy, was 163.4 ± 30.40 minutes. In 56 cases, which were completed by a two-incision VATS lobectomy for primary lung cancer, a total number of dissected lymph nodes per patient were 20.2 ± 11.2. The chest tube was removed on postoperative day 5.4 ± 2.8, and there was no occurrence of major perioperative morbidity and mortality. CONCLUSIONS: Two-incision VATS lobectomy is applicable in the selected cases, and may obtain similar results with the conventional VATS lobectomy, through a certain period of learning curve.onal VATS lobectomy, through a certain period of learning curve.
    Journal of Cardiothoracic Surgery 04/2013; 8(1):88. · 0.90 Impact Factor
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    ABSTRACT: OBJECTIVES: The purpose of this study was to assess the usefulness of dual-energy perfusion computed tomography (CT) for predicting postoperative lung function in patients undergoing lung resection. METHODS: Fifty-one patients (38 men, 13 women; mean age, 63.8 years) were prospectively enrolled and subsequently underwent dual-energy CT, perfusion scintigraphy, a pulmonary function test before surgery, and a pulmonary function test 6 months after surgery. Computed tomography was performed using dual-source CT with the dual-energy technique. Using weighted average images, each lobe was segmented and using perfusion images, the iodine value was quantitatively measured. Lobar perfusion was calculated by multiplying the volume of the lobe by the iodine value. The ratio of lobar perfusion per whole-lung perfusion was then calculated. The predicted postoperative forced expiratory volume during 1 second (post-FEV1) was calculated by multiplying the preoperative FEV1 by the fractional contribution of perfusion of the remaining lung. The agreement between the predicted post-FEV1 and the actual post-FEV1 was then evaluated. The percentage of error of the predicted post-FEV1 to that of the actual post-FEV1 was then calculated. RESULTS: Using the Bland-Altman method, the limits of agreement between the actual post-FEV1 and the predicted post-FEV1 were -29.3% and 26.9% for scintigraphy and -28.9% and 17.3% for CT. The percentage of error of CT (15.4%) was comparable with that of scintigraphy (17.8%). CONCLUSIONS: Dual-energy perfusion CT was more accurate than perfusion scintigraphy was for predicting postoperative lung function.
    Investigative radiology 03/2013; · 4.85 Impact Factor
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    ABSTRACT: Nuclear factor-κB (NF-κB) is involved in proliferation, angiogenesis, and metastasis in various malignancies; however, the role of NF-κB in papillary thyroid carcinoma (PTC) has not been fully elucidated. The purpose of this study was to elucidate the role and clinicopathological significance of the NF-κB signaling pathway in PTC. We investigated NF-κB RelA expression in 122 patients with conventional PTC by immunohistochemistry, and evaluated the correlation between RelA expression and clinicopathological parameters, including BRAF(V600E) mutation. Nuclear expression of NF-κB RelA, regardless of cytoplasmic expression, was identified in 91 of 122 PTCs (74.6%), and was more frequent in PTCs larger than 1cm (overt PTC) (P=0.001). There were significant differences in clinicopathological parameters, such as extrathyroidal extension (P=0.031), nodal metastasis (P=0.021) and BRAF(V600E) mutation (P=0.039), between NF-κB-positive and negative PTCs. Proliferation index was strongly associated with NF-κB activation (P=0.045) but not with BRAF(V600E) mutation (P=0.141). Taken together, our results suggest that NF-κB RelA activation contributes, at least in part, to tumor growth and aggressiveness of PTC after tumor transformation. The expression pattern of NF-κB may serve as a prognostic marker and a potential therapeutic target.
    Pathology - Research and Practice 03/2013; · 1.21 Impact Factor
  • The British journal of radiology 02/2013; · 2.11 Impact Factor

Publication Stats

691 Citations
330.25 Total Impact Points

Institutions

  • 2014
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
  • 2009–2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2013
    • CHA University
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Soonchunhyang University
      • • College of Medicine
      • • Department of Chemistry
      Onyang, South Chungcheong, South Korea
  • 2006–2013
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2005–2013
    • Seoul National University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2011–2012
    • Eulji University
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea
    • Soongsil University
      • Department of Electronic Engineering
      Seoul, Seoul, South Korea
    • Hallym University
      • College of Medicine
      Seoul, Seoul, South Korea
    • Catholic University of Korea
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2005–2012
    • Chonnam National University
      • • School of Biological Sciences and Technology
      • • Hormone Research Center
      Yeoju, Gyeonggi, South Korea
  • 2008–2011
    • Asan Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2004–2011
    • Ewha Womans University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Korea Institute of Toxicology
      Sŏul, Seoul, South Korea
    • Pusan National University
      • College of Pharmacy
      Pusan, Busan, South Korea
  • 2010
    • Korea Institute of Science and Technology
      • Clean Energy Research Center
      Sŏul, Seoul, South Korea
    • Seoul National University Bundang Hospital
      Sŏul, Seoul, South Korea
  • 2007
    • Sungkyunkwan University
      • Samsung Medical Center
      Seoul, Seoul, South Korea
  • 2006–2007
    • Chosun University
      • Department of Physics Education
      Gwangju, Gwangju, South Korea
  • 2004–2006
    • Chungbuk National University
      • College of Veterinary Medicine
      Tyundyu, North Chungcheong, South Korea