Susmita Santra

IIT Kharagpur, Khargpur, Bengal, India

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Publications (6)7.66 Total impact

  • Susmita Santra · Girija Srinarayan · Panchanan Pramanik
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    ABSTRACT: Nanostructured ceramic oxides exhibit novel and appreciable mechanical, electrical and magnetic properties in comparison with the bulk counterparts and therefore offer many industrial applications. Most of the research in the field of nanoscience in the past two decades has been dedicated to the synthesis routes of the fine particles. This review presents an overview of the generally followed methods for the synthesis of fine ceramic oxides with special focus on the methods suitable for bulk production of fine ceramics, particularly on the methods developed by the authors. The method developed by the authors basically involves evaporation/flame pyrolysis of a precursor solution constituting the desired metal ions dispersed in a polymeric reagent (polyhydroxy-organics). Afterward the process has been improved involving metal ions complexed with a chelating agent (diethanolamine triethanolamine, inorganic acids such as citric/oxalic/tartaric acid, EDTA, etc) and simple polyhydroxy organic compound. These reagents (polymeric/chelating/organic) play a dual role of keeping the solution homogeneous preventing precipitation of metal ions from solution during pyrolysis, and acting as template for the formation of nanostructures during combustion. A number of single phase ceramic oxides with size ranging from 10-90 nm with a narrow particle size distribution have been synthesized by the developed methods and characterized.
    Transactions - Indian Ceramic Society 01/2015; 69(3):115-124. DOI:10.1080/0371750X.2010.11090827 · 0.23 Impact Factor
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    ABSTRACT: The development of smart targeted nanoparticle that can deliver drugs to direct cancer cells, introduces better efficacy and lower toxicity for treatment. We report the development and characterizations of pH-sensitive carboxymethyl chitosan modified folic acid nanoparticles and manifest their feasibility as an effective targeted drug delivery vehicle. The nanoparticles have been synthesized from carboxymethyl chitosan with covalently bonded bifunctional 2,2'-(ethylenedioxy)-bis-(ethylamine) (EDBE) through the conjugation with folic acid. The conjugation has been analyzed by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The resultant nanoparticles with an average size less then 200 nm measured by dynamic light scattering and transmission electron microscopy. Confocal microscopy and flow cytometric analysis have revealed that folate-mediated targeting significantly enhances the cellular uptake of the nanoparticle and thus facilitates apoptosis of cancer cells (HeLa, B16F1). For the application of the nanoparticles as a drug carrier, Doxorubicin a potent anticancer drug has been loaded into the nanoparticles, with the drug loading amount and the drug release pattern observed.
    Journal of Materials Science Materials in Medicine 05/2010; 21(5):1587-97. DOI:10.1007/s10856-010-3998-4 · 2.38 Impact Factor
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    ABSTRACT: More than 90% of Staphylococcus strains are resistant to penicillin. In 1961 S. aureus developed resistance to methicillin (MRSA), invalidating almost all antibiotics, including the most potent beta-lactams. Vancomycin, a glycopeptide antibiotic, was used for the treatment of MRSA in 1980. Vancomycin inhibits the bio-synthesis of peptidoglycan and the assembly of NAM-NAG-polypeptide into the growing peptidoglycan chain. Vancomycin resistant S. aureus (VRSA) first appeared in the USA in 2002. Folic acid tagged chitosan nanoparticles are used as Trojan horses to deliver vancomycin into bacterial cells. These nanoparticles are biocompatible and biodegradable semisynthetic polymers. These nanosized vehicles enhance the transport of vancomycin across epithelial surfaces and show its efficient drug action, which has been understood from studies of the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles of a chitosan derivative loaded with vancomycin. Tolerance values distinctly show that vancomycin loaded into nanoconjugate is very effective and has a strong bactericidal effect on VRSA.
    Nanotechnology 02/2010; 21(10):105103. DOI:10.1088/0957-4484/21/10/105103 · 3.67 Impact Factor
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    ABSTRACT: Alpha alumina powders have been prepared by the pyrolysis of sucrose, aluminium nitrate and ammonium nitrate. After spray pyrolysis at 400°C the mixture yields fluffy light brown precursor mass. After grinding followed by heat-treatment at 900°C and 1000°C it produced the alpha-alumina having particle sizes of 42 nm and 55 nm with surface area 12 m²/gm and 16 m²/gm respectively. The yield per unit time from precursor with ammonium nitrate is 3-4 times that of simple thermal spray pyrolysis without ammonium nitrate. The particle size and crystallite size have been decreased with increase of sucrose commensurated with ammonium nitrate in the reaction mixture. The crystallite sizes are comparable with particle sizes due to poor agglomeration due to excess addition of sucrose and ammonium nitrate.
    International Journal of Nanotechnology 01/2010; 7. DOI:10.1504/IJNT.2010.034705 · 1.14 Impact Factor
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    ABSTRACT: Study was focused to effectively suppress the agglutinability of human A and B type erythrocyte by concerted chemical oxidation approach. Consequently some major bio-physiological consequences of human erythrocytes were analyzed. Concerted chemical oxidation of human A and B type erythrocyte were done by potassium permanganate (KMnO(4)) in presence of ethylene diamine tetra-acetic acid (EDTA). All the chemical reactions were carried out at 37°C temperature and pH 7.4 in phosphate buffer. Finally, suppression of agglutinability were determined by using anti-A and anti-B antisera. A marked suppression in agglutinability was observed after chemical treatment on human A and B type erythrocytes in vitro. Effective suppression of agglutinability was observed in 0.57 mM concentration of KMnO(4) in presence of 0.9 mM EDTA at optimum condition. Results showed that KMnO(4)-EDTA concerted action is feasible. The future work is directed towards the universal human erythrocytes preparation from A and B type human erythrocytes.
    Indian Journal of Hematology and Blood Transfusion 09/2009; 25(3):104-10. DOI:10.1007/s12288-009-0022-6 · 0.23 Impact Factor