Liang-Ho Lin

Chang Gung University, Hsin-chu-hsien, Taiwan, Taiwan

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Publications (4)2.39 Total impact

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    ABSTRACT: Most Western studies do not recommend interrupting warfarin therapy or replacing it with heparin prior to tooth extraction if the international normalized ratio (INR) levels are maintained. However, this issue remains controversial in Taiwan. The aim of this study was to investigate whether Taiwanese patients who had an INR within the therapeutic range required cessation of warfarin prior to dental extractions.
  • Shin-Yu Lu, Chi-Cheng Liang, Liang-Ho Lin
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    ABSTRACT: Background/purpose Bisphosphonate-related osteonecrosis of the jaw (BRONJ) appears to be refractory to conventional treatment approaches. We offer our experiences and treatment strategies regarding the successful resolution of BRONJ. Materials and methods Thirty sites of BRONJ in 27 patients were clinicopathologically proven. The mandible was more commonly affected than the maxilla (67% versus 33%). The appearance of 23 (77%) BRONJ sites was preceded by a tooth extraction, dental infection, or oral trauma, and the remaining sites occurred spontaneously. There was a female predilection with a ratio of 3.5:1, and 22 (81%) patients were oral bisphosphonate (BPh) users. The treatment strategies included: (1) nonsurgical treatment using antimicrobial rinses; (2) removal of necrotic bone followed by insertion of Gelfoam impregnated with tetracycline; or (3) filling with alloplastic bone substitute plus tetracycline as the procedure of guided bone regeneration (GBR); and (4) radical resection of all necrotic bone and immediate reconstruction. Results In 25 (93%) patients with 27 (90%) sites, BRONJ was successfully treated. The three treatment failures were all in two intravenous BPh users. There was no significant dependence of the treatment results on the severity of BRONJ. However, there was a significant dependence of the treatment result on the route of BPh administration. Conclusion Our study demonstrates a high success rate of conservative and surgical treatment of BRONJ. This is the first reported use of GBR to successfully treat oral BPh-related osteonecrosis of the jaw. Irrigation with antimicrobial rinses may result in pain reduction, and regression or even resolution of BRONJ.
    Journal of dental sciences 06/2014; 9(2):185–194. DOI:10.1016/j.jds.2013.03.004 · 0.47 Impact Factor
  • Liang-Ho Lin, Shin-Yu Lu, Sheng-Nan Lu
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    ABSTRACT: A possible association between oral lichen planus (OLP) and hepatitis C virus (HCV) infection has been documented in certain populations such as Japan and Southern Europe; however, the issue remains controversial. The aim of this study was to investigate the prevalence of HCV antibodies among patients with OLP in Southern Taiwan, and to assess the possible association between OLP and HCV infection. All patients enrolled in the study sought care at a hospital dental clinic. Serum samples of 104 patients with OLP and 100 controls with healthy oral mucosa, whose age and gender were matched, were respectively screened for anti-HCV antibodies by the microparticle enzyme immunoassay (AxSYM HCV version 3.0). The prevalence of HCV infection was 22.1% in the study group (23 of 104 OLP patients) and 2% in the control group (2 of 100 control subjects) respectively (P < .001). Eleven of 23 HCV-infected OLP patients (47.8%) were unaware of their HCV infection status in the study. A positive association between OLP and HCV in Southern Taiwan exists, suggesting that routine HCV infection testing of patients with OLP in Southern Taiwan should be considered.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 03/2010; 109(3):408-14. DOI:10.1016/j.tripleo.2009.10.005 · 1.46 Impact Factor
  • Journal of dental sciences 12/2009; 4(4):191-197. DOI:10.1016/S1991-7902(09)60026-X · 0.47 Impact Factor