Publications (2)0.13 Total impact
Article: [A case of cerebral infarction treated with tissue-plasminogen activator exhibiting prolonged cerebral edema for more than 1 month].[show abstract] [hide abstract]
ABSTRACT: A 62-year-old man with hypertension and diabetes mellitus controlled by medication suddenly noticed slight hemiparesis and was admitted to our hospital. Tissue-plasminogen activator (t-PA) was administered as his NIHSS was 6 and there were no contraindications. His symptoms completely resolved after t-PA injection. He was discharged on Day 9 without neurological deficits despite minor bleeding being detected in a small, low-density area in the right post-central region on CT. However, the hemiparesis gradually recurred subsequently and the low-density area had increased. He was readmitted on Day 38 due to deterioration of symptoms and enhanced CT imaging exhibited a large, low-density area in the central parasagittal region with enhancement was seen. An open biopsy was performed on Day 52 for diagnostic purposes. Histology demonstrated increased small vessels surrounded by many non-specific inflammatory cells and abundant reactive astrocytes. To date, reports of prolonged cerebral edema lasting more than 1 month after cerebral infarction are rare. This condition may be due to angiogenesis induced by t-PA. Another reason may have been the location, i.e., the parasagittal region, which is the most common area for severe cerebral edema after gamma knife surgery.Brain and nerve = Shinkei kenkyū no shinpo 01/2012; 64(1):79-84.
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ABSTRACT: We report a case of gangliocytoma at a cortical and subcortical area in the right parietal lobe. The patient had a generalized seizure at 11 years of age. The MRI shows an ill-demarcated high intensity area in T2 weighted images including an enhancing tumor of 10 mm in diameter. At first, the tumor was carefully followed up because of its small size and the surgical risk. Three years after the onset, a cyst formed at the area of the brain edema adjacent to the tumor. The cyst gradually grew to 21 mm in diameter, the edema had disappeared, and the size of the tumor became smaller (7 mm) within the next 3 years. A mural nodule, jelly-like tumor with calcification was totally removed and diagnosed as gangliocytoma. The cyst fluid was watery-clear, its wall did not contain any tumor. This is the first report of a six-year follow-up of cyst formation of gangliocytoma supporting the concept that edema is a precursor to central nervous system peritumoral cyst formation based on the similar observation of hemangioblastomas.No shinkei geka. Neurological surgery 01/2010; 38(1):61-6. · 0.13 Impact Factor