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ABSTRACT: The aim of this study was to retrospectively correlate FDG uptake in primary Ewing sarcoma family of tumors (ESFT) with tumor behavior, and to evaluate whether FDG PET can be used to predict response to neoadjuvant chemotherapy (NACT) in this patient group.
Out of the total 54 patients of recently diagnosed ESFT who underwent pretreatment FDG PET imaging, group I included patients without metastasis at presentation (n = 34) and group II included those with metastasis at presentation (n = 20). Fourteen of these patients had undergone FDG PET after 4 cycles of induction chemotherapy and surgical resection of primary tumor. In this subgroup of 14 patients, maximum standardized uptake value (SUVmax) of primary tumor was estimated before and after 4 cycles of induction chemotherapy and was correlated with the histopathological response in terms of necrosis in the tumor specimen.
Mean SUVmax in the primary tumor in group I patients was 6.84 and in group II patients, it was 11.31. The difference between mean SUVmax of these 2 groups was significant by Wilcoxon test analysis, with P < 0.01. In group II patients, SUVmax in metastasis with maximum FDG uptake was consistently lower as compared with that of primary tumor. In subgroup of 14 patients, Pearson correlation analysis showed that percentage change in SUVmax of primary tumor correlated well with percentage necrosis on histopathological examination (P < 0.01).
FDG uptake in primary ESFT reflected its metastatic potential and hence the aggressive behavior. The significant correlation between change in metabolic activity of the primary tumor and histopathological response after neoadjuvant chemotherapy suggests that FDG PET may be an ideal noninvasive method to assess tumor behavior and response to therapy in ESFT.
Clinical nuclear medicine 11/2011; 36(11):973-7. · 3.92 Impact Factor
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ABSTRACT: The standard care for muscle-invasive carcinomas of the urinary bladder is neoadjuvant chemotherapy followed by radical cystectomy and a urinary diversion procedure. Recurrence of urothelial cancer in an ileal conduit is known, but is exceedingly rare, with only a few cases reported thus far. The sensitivity of conventional positron emission tomography (PET), using flourodeoxy glucose (FDG) as the tracer, in detection of primary as well as recurrent urothelial cancers is low. We discuss a case of recurrent urothelial cancer occurring in an ileal conduit detected on positron emission tomography-computed tomography (PET-CT) and confirmed histopathologically.
Clinical nuclear medicine 01/2010; 35(1):42-3. · 3.92 Impact Factor
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ABSTRACT: Positron emission tomography (PET) using flourodeoxyglucose (FDG) is routinely used for initial staging and restaging of colorectal cancers. However FDG PET studies can suffer from false-positive tracer uptake due to a variety of physiological and inflammatory conditions arising in the abdomen and pelvis. Epiploic appendagitis is one such condition that can give rise to increased glucose concentration on a FDG PET study. We describe the etiology, clinical presentation, computerized tomography scan and FDG PET-computed tomography findings of this unusual inflammatory condition in an operated case of colorectal cancer.
Clinical nuclear medicine 12/2009; 34(12):906-8. · 3.92 Impact Factor
