Toshitaka Mori

Aichi Medical University, Koromo, Aichi, Japan

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Publications (13)15.24 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to assess vascular endothelial reactivity and carotid intima-media thickness in women with early- and late-onset preeclampsia, and with chronic hypertension. A total of 28 women with uncomplicated pregnancies, 25 women with early-onset preeclampsia, 36 women with late-onset preeclampsia and 26 women with chronic hypertension were evaluated. We measured flow-mediated vasodilation in the brachial artery (FMD; marker of endothelial function), and intima-media thickness in the carotid artery (IMT; marker of atherogenesis) in women with early-onset preeclampsia during pregnancy and three months after delivery, and compared these parameters with those in normal, late-onset preeclampsia, and chronic hypertension. FMD was significantly lower during pregnancy in both preeclamptic and chronic hypertension groups, compared to the control group. FMD in late-onset preeclamptic group significantly increased and normalized 3 months after delivery. Although, FMD in the early-onset preeclamptic and chronic hypertension groups significantly increased 3 months after delivery, it showed still lower than control. IMT in early-onset preeclamptic and chronic hypertension groups, but not late-onset preeclamptic group, were significantly larger than that in control group. These findings suggest that endothelial dysfunction is irreversible and atherosclerotic changes might be enhanced in women with early-onset preeclampsia and chronic hypertension. T. Mori: None. K. Watanabe: None. A. Iwasaki: None. C. Kimura: None. A. Wakatsuki: None. Copyright © 2014.
    01/2015; 5(1):147. DOI:10.1016/j.preghy.2014.10.303
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    ABSTRACT: This study aimed to assess whether pregnancy induced hypertension (PIH) affects the risk of cardiovascular disease (CVD) in later life in Japanese women. The eligible study population consisted of 1100 women who were ⩾40 years old, underwent a health check-up at a periodic health examination facility in Aichi, Japan, between January 2012 and December 2013, and had experience giving birth. Questionnaires were sent to potential participants and they were encouraged to provide their Maternal and Child Health Handbooks. We recruited women with a history of PIH (PIH group) and women with uncomplicated pregnancies (control group). Information was obtained from the Maternal and Child Health Handbooks. We assessed the association between history of PIH and risk of CVD such as hypertension, diabetes mellitus, and dyslipidemia in later life. Antihypertensive medication use rate was higher in PIH group compared to those without PIH. With respect to risk factors for CVD, triglycerides were significantly higher, while HDL-cholesterol was significantly lower in the PIH group compared to control group. The PIH group showed a significantly higher proportion of dyslipidemic medication use after menopause. Our findings suggest that Japanese women with a history of PIH may have an increased risk of hypertension and dyslipidemia in later life. K. Watanabe: None. C. Kimura: None. A. Iwasaki: None. T. Mori: None. H. Matsushita: None. K. Shinohara: None. A. Wakatsuki: None. Copyright © 2014.
    01/2015; 5(1):74. DOI:10.1016/j.preghy.2014.10.148
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    ABSTRACT: This study aimed to assess whether changes in blood pressure during pregnancy is associated with hypertension in later life in Japanese women with or without pregnancy induced hypertension (PIH). The eligible study population consisted of 1100 women who were ⩾40 years old, underwent a health check-up at a periodic health examination facility in Aichi, Japan, between January 2012 and December 2013, and had experience giving birth. Questionnaires were sent to potential participants and they were encouraged to provide their Maternal and Child Health Handbooks. We recruited women with a history of PIH (PIH group) and of uncomplicated pregnancies at delivery (control group). Information obtained from the Maternal and Child Health Handbooks. Participants were divided into five periods of whole gestation period and the average maximum value of systolic blood pressure calculated in each period. We assessed the association between changes in average systolic blood pressures during pregnancy and hypertension in later life in Japanese women with or without PIH. The odds ratios (OR) of antihypertensive medication use for the PIH group in later life was 4.31 (95%CI, 2.69-6.88) by average blood pressure 10mmHg rise during pregnancy, OR for the control group was 1.38 (95%CI, 1.01-1.90). Our findings suggest that high blood pressure during pregnancy in women without a history of PIH is high risk of hypertension in later life. C. Kimura: None. K. Watanabe: None. A. Iwasaki: None. T. Mori: None. H. Matsushita: None. K. Shinohara: None. A. Wakatsuki: None. Copyright © 2014.
    01/2015; 5(1):80. DOI:10.1016/j.preghy.2014.10.160
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    ABSTRACT: Objective: This study assessed whether pregnancy-induced hypertension (PIH) affects the prevalence of cardiovascular disease (CVD) risk factors in later life among Japanese women. Methods: Study participants were 1,185 women (mean [SD] age, 46.5 [5.6] y; range, 38-73 y) aged 40 years or older who underwent a health checkup at a periodic health examination facility between January 2012 and December 2013 and had experienced giving birth. Questionnaires were sent to potential participants, and they were encouraged to provide their Maternal and Child Health Handbook (handbook). We recruited 101 women with a history of PIH (PIH group) and 1,084 women with uncomplicated pregnancy at delivery (control group). Groupings were based on information from the handbook. We assessed the association between PIH and CVD in later life among Japanese women by focusing on hypertension, diabetes mellitus, and dyslipidemia as risk factors for CVD. Odds ratios (ORs) for the use of antihypertensive, diabetes mellitus, and dyslipidemic medications in the PIH group were determined. Results: Women with PIH had increased risk of antihypertensive medication use compared with women without PIH (2.9% vs 13.9%; OR, 4.28; 95% CI, 2.14-8.57). Triglycerides were significantly higher and high-density lipoprotein cholesterol was significantly lower in the PIH group than in the control group. The OR for dyslipidemic medication use in the PIH group relative to the control group was 3.20 (95% CI, 1.42-7.22). Conclusions: Our findings suggest that a history of PIH may be associated with an increased risk of hypertension (a risk factor for CVD) in later life among Japanese women.
    Menopause (New York, N.Y.) 11/2014; 22(6). DOI:10.1097/GME.0000000000000361 · 2.81 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate the distinct pathogenic mechanisms underlying chronic hypertension in pregnancy and preeclampsia in terms of oxidative stress and vascular reactivity. A total of 17 women with uncomplicated pregnancies, 30 women with preeclampsia and 17 women with chronic hypertension were evaluated. We measured serum derivatives of reactive oxygen metabolites (d-ROMs; marker of oxygen free radicals), flow-mediated vasodilation (FMD; marker of endothelial function) and intima-media thickness in the carotid artery (IMT; marker of atherogenesis) during pregnancy and 1 month after delivery. Serum d-ROM concentrations were significantly higher in women with chronic hypertension and severe preeclampsia than in the control group during pregnancy. d-ROM concentrations in all groups significantly decreased to similar levels 1 month after delivery. FMD was significantly lower during pregnancy in preeclamptic and chronic hypertension groups compared with the control group. FMD in preeclamptic groups significantly increased and normalized to control levels after delivery. Similarly, FMD in the chronic hypertension group significantly increased after delivery but was still lower. IMT in the chronic hypertension group was significantly higher than that in control and preeclamptic groups. These findings suggest that endothelial dysfunction induced by enhanced oxidative stress is reversible in women with preeclampsia, whereas impaired vascular reactivity may be associated with atherosclerotic changes in women with chronic hypertension.Hypertension Research advance online publication, 26 September 2013; doi:10.1038/hr.2013.131.
    Hypertension Research 09/2013; DOI:10.1038/hr.2013.131 · 2.94 Impact Factor
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    ABSTRACT: Abstract Objective: To determine there are different in those production levels of oxygen free radical between mothers and neonates by the mode of delivery, we measured oxygen free radical concentrations in maternal vein and umbilical artery. Methods: Forty-four women with singleton term pregnancies were prospectively recruited and classified into two groups: those who had a spontaneous uncomplicated vaginal delivery (VD group; n = 21), and those who had an elective cesarean delivery (CD group; n = 23). We determined maternal and fetal oxidative stress levels by measuring concentrations of derivatives of reactive oxygen metabolites (d-ROMs) in maternal vein before delivery and on postnatal day 5, and in umbilical artery at delivery. We also measured the pH, partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), and base excess (BE) in umbilical artery blood collected at delivery. Results: The concentrations of d-ROMs in maternal vein on postnatal day 5 were significantly decreased in the VD group, but were significantly increased in the CD group, compared to before delivery. The concentrations of d-ROMs in umbilical artery were significantly higher in the VD group than the CD group. Compared to the CD group, umbilical artery pH tended to be lower (p=0.07), and BE significantly lower (p<0.005), in the VD group. There were no significant differences in umbilical artery PaO2 and PaCO2 between the two groups. Conclusion: Our findings indicate that those production levels of oxygen free radical in mothers are greater by CD than by VD, while those in neonates are greater by VD than by CD.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 04/2013; DOI:10.3109/14767058.2013.794209 · 1.21 Impact Factor
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    ABSTRACT: The purpose of the present study was to determine whether oxidative stress occurring in the maternal body also affects the fetus in preeclamptic women with FGR. We ∥@consecutively recruited 17 preeclamptic women with FGR, 16 preeclamptic women without FGR, and 16 healthy pregnant women with uncomplicated pregnancy. We measured concentrations of derivatives of reactive oxygen metabolites (d-ROMs) as a marker of oxygen free radicals in a maternal vein, umbilical artery, and umbilical vein. ∥@Maternal d-ROM levels were higher in preeclamptic groups compared to the control group. Umbilical artery and vein d-ROM levels were elevated in preeclamptic women with FGR compared to the control group. Umbilical artery d-ROM levels were significantly higher than in the vein in preeclamptic women with FGR, but not in those without FGR. Umbilical arterial blood pH was significantly lower in preeclamptic women with FGR. The partial pressure of oxygen (PaO2) in umbilical arterial blood tended to be lower in preeclamptic women with FGR (p=0.08). The partial pressure of carbon dioxide (PaCO2) in umbilical arterial blood was significantly higher in preeclamptic women with FGR. These results indicate that oxidative stress occurring in the maternal body also affects the fetus in preeclamptic women with FGR. Copyright © 2013. Published by Elsevier B.V.
    04/2013; 3(2):82. DOI:10.1016/j.preghy.2013.04.070
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    ABSTRACT: To determine whether enhanced oxidative stress during pregnancy impairs vascular endothelial function and improves after delivery in preeclamptic women, we measured serum parameters of oxidative stress and endothelial function during pregnancy and 1 month after delivery in women with or without preeclampsia. We evaluated 18 participants with uncomplicated pregnancies, 11 with mild preeclampsia and 13 with severe preeclampsia. The plasma concentrations of reactive oxygen metabolite derivatives (d-ROMs) were measured, and the biological antioxidant potential (BAP) was determined to evaluate the oxygen free radicals and antioxidants, respectively. Flow-mediated vasodilation (FMD) was also assessed as a marker of endothelial function. FMD was decreased significantly in both preeclamptic groups compared with control during pregnancy. FMD did not change after delivery in the control group, but it significantly increased after delivery in both the mildly and severely preeclamptic groups, nearing control levels 1 month after delivery (mild, 6.5±3.6-9.0±3.5%; severe, 4.3±3.3-9.7±2.6%). No changes in d-ROM concentrations were observed in the control group; however, the concentrations in both the mildly and severely preeclamptic groups significantly decreased to normal levels 1 month after delivery (mild, 562.0±106.5-430.5±90.5 CARR U (Carratelli units); severe, 681.0±239.0-411.8±69.7 CARR U). The plasma BAP levels did not change significantly in all three groups. A negative correlation between FMD and d-ROM concentrations was observed in the preeclamptic group, but not in the control group (r=-0.497; P<0.05). Our findings indicated that enhanced oxidative stress during pregnancy may impair endothelial function and improve after delivery in preeclamptic women.Hypertension Research advance online publication, 17 January 2013; doi:10.1038/hr.2012.208.
    Hypertension Research 01/2013; 36(4). DOI:10.1038/hr.2012.208 · 2.94 Impact Factor
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    01/2013; 1(2):98-102. DOI:10.14390/jsshp.1.98
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    ABSTRACT: Abstract To investigate the relation between the severity of hypoxic changes and oxidative DNA damage in the placenta of early and late-onset preeclampic women and FGR, serum parameters of oxidative stress, placental hypoxic change, and oxidative DNA damage were determined.We examined 10 participants with uncomplicated pregnancies, 13 with early-onset and 12 with late-onset preeclampsia. Maternal and umbilical plasma derivatives of reactive oxygen metabolites (d-ROMs) were measured as markers of oxygen free radicals. Immunohistochemical analysis was performed to measure the proportion of placental trophoblast cell nuclei staining positive for 8-hydroxy-2'-deoxyguanosine (8-OHdG), redox factor-1 (ref-1), and hypoxia-induced factor-1α (HIF-1α), which are markers of oxidative DNA damage, repair functions, and hypoxia status, respectively. 8-OHdG was higher in both preeclamptic groups, but significantly higher in the early-onset preeclamptic group. Ref-1 was higher in the late-onset preeclamptic group. HIF-1α was higher in both preeclamptic groups, with a tendency towards a higher in the early-onset preeclamptic group. Our findings indicate that the severity of hypoxic changes and oxidative DNA damage are greater in the placenta of women with early-onset preeclampsia, and that the prolonged preeclamptic conditions may reduce placental blood flow, ultimately leading to fetal growth restriction (FGR).
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 10/2012; 26(5). DOI:10.3109/14767058.2012.733766 · 1.21 Impact Factor
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    ABSTRACT: Objective: The purpose of this study was to evaluate the association of vascular endothelial dysfunction with increased oxidant generation in the metabolism of hypoxanthine to uric acid in early-onset compared to late-onset preeclampsia. Methods: We investigated 12 women with early-onset preeclampsia, 14 women with late-onset preeclampsia, and 20 women with uncomplicated pregnancies. We measured serum derivatives of reactive oxygen metabolites (d-ROMs) as a marker of oxygen free radicals, serum biological antioxidant potential (BAP), hypoxanthine, uric acid, uric acid clearance (CUA), and flow-mediated vasodilation (FMD) as a marker of endothelial function in preeclamptic women. Results: Concentration of d-ROMs was significantly higher in both preeclamptic groups compared to the control group. Plasma levels of uric acid were significantly elevated in both preeclamptic groups compared to the control group. Plasma levels of hypoxanthine were significantly higher in early-onset preeclamptic women compared to controls, but not in late-onset preeclamptic women. CUA was significantly lower in late-onset preeclamptic women compared to controls, but not in early-onset preeclamptic women. The concentrations of hypoxanthine and uric acid correlated positively with the concentration of d-ROMs in all pregnant women. FMD was significantly lower in both preeclamptic groups compared with controls, but FMD in the early-onset preeclamptic group was significantly lower than in the late-onset preeclamptic group. Conclusions: We found that increased oxidant generation during metabolism of hypoxanthine to uric acid may impair endothelial function in early-onset preeclampsia.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 06/2012; 25(12). DOI:10.3109/14767058.2012.705396 · 1.21 Impact Factor
  • 10/2010; 1. DOI:10.1016/S2210-7789(10)60195-X
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    ABSTRACT: Visceral fat accumulation stimulates the production of adipocytokines in patients with metabolic syndrome. Excess body weight gain during pregnancy is a risk factor for preeclampsia. To evaluate whether the pathogenesis of preeclampsia is similar to that of metabolic syndrome, we measured plasma adipocytokine concentrations and investigated the association between plasma adiponectin concentrations and body weight gain or endothelial function in preeclamptic women. We investigated 15 preeclamptic and 17 women with uncomplicated pregnancies. Women with preeclampsia had significantly lower plasma concentrations of adiponectin (10.2+/-2.0 vs. 7.3+/-2.2 microg ml(-1), P<0.01), but higher concentrations of leptin, plasminogen activator inhibitor-1, interleukin-6, vascular cell adhesion molecule-1, E-selectin and C-reactive protein. Plasma triglyceride levels were significantly higher in preeclamptic patients, but the levels of other lipids did not differ significantly between the two groups. We found that flow-mediated vasodilation was significantly decreased in preeclamptic women compared with controls (10.6+/-6.4 vs. 3.8+/-2.0%, P<0.001). Plasma adiponectin concentrations correlated negatively with body mass index (r=-0.50, P<0.05) and body weight gain during pregnancy (r=-0.63, P<0.01), and positively with flow-mediated vasodilation (r=0.50, P<0.05) in preeclamptic women, but not in women with uncomplicated pregnancies. Similar to the patients with metabolic syndrome, we found that dysregulation of adipocytokines, such as low adiponectin levels and high levels of other adipocytokines, and excess body weight gain during pregnancy, may decrease plasma adiponectin concentrations that are associated with endothelial dysfunction in preeclamptic women.
    Hypertension Research 03/2010; 33(3):250-4. DOI:10.1038/hr.2009.222 · 2.94 Impact Factor