Nitin Gupta

Publications of Nitin Gupta

• Rituximab in Steroid Refractory Autoimmune Hemolytic Anemia.

  Authors: Nitin Gupta, Sanjeev Sharma, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra, Suman Kumar, Rajan Kapoor, Narendra Agarwal

  Indian journal of pediatrics. 08/2011;

  Autoimmune hemolytic anemia is rare in children and infants and steroids are the corner stone of therapy. Management of the patients with steroid refractory/dependent disease is difficult .RituximabAutoimmune hemolytic anemia is rare in children and infants and steroids are the corner stone of therapy. Management of the patients with steroid refractory/dependent disease is difficult .Rituximab is being used in the treatment of a variety of autoimmune diseases including Autoimmune hemolytic anemia (AIHA),especially in adults but there is scarce data regarding the use of this agent in pediatric AIHA patients.The authors report two cases of steroid refractory AIHA, who responded to rituximab with review the literature of its use in pediatrics.

• Successful management of refractory chronic immune thrombocytopenia with intracranial hemorrhage by emergency splenectomy.

  Authors: Sanjeev Kumar Sharma, Nitin Gupta, Tulika Seth, M Srinivas, Pravas Mishra, Manoranjan Mahapatra

  Indian journal of pediatrics. 07/2011; 79(3):397-8.

• Treatment of acute myeloid leukemia in children: experience from a tertiary care hematology centre in India.

  Authors: Nitin Gupta, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra, Shyam Rathi, Rajan Kapoor, Narendra Agarwal, Suman Kumar, Renu Saxena

  Indian journal of pediatrics. 05/2011; 78(10):1211-5.

  To assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. SecondaryTo assess the treatment and outcome of children with acute myeloid leukemia. The Primary objectives were to assess remission rates, treatment related toxicity and disease free survival. Secondary objective was to assess prognostic factors associated with poor outcome. A retrospective analysis of all treated patients with acute myeloid leukemia, less than 18 year of age from Sept 2005 to Aug 2009 was done. Clinical laboratory, treatment and follow up records retrieved to calculate remission rate, treatment related toxicity, disease free survival and poor prognostic factors. This analysis included thirty five patients (male : female; 23:12), twenty seven (77.1%) achieved remission after one 3 + 7 induction and seven required two inductions. High dose cytosine arabinoside consolidation was given in thirty one patients while one underwent allogenic stem cell transplantation. Two patients died during chemotherapy (TRM- 5.7%), two did not complete the therapy, seventeen relapsed (48.5%) with 80% of relapses occurring within first year of remission and no relapse occurred after 2 years. Fourteen patients are in remission (40%, follow up 5-54 months) and cumulative median disease free survival is of 13 months. The present data suggests that 3 + 7 induction, followed by high dose cytarabine consolidation has low treatment related toxicity and resource utilization; however, relapse free survival is inferior to more intensive regimens, highlighting the need to intensify chemotherapy regimen once the treatment related mortality has been minimized.

• Acute renal failure following antithymocyte globulin therapy for aplastic anaemia-report of two cases and review of literature.

  Authors: Nitin Gupta, Manoranjan Mahapatra, Shyam Rathi, Rajan Kapoor, Avinash Singh, Tulika Seth, Pravas Mishra

  Annals of hematology. 02/2011; 90(2):239-41.

• Clinical profile of dengue infection in patients with hematological diseases.

  Authors: Sanjeev Kumar Sharma, Tulika Seth, Pravas Mishra, Nitin Gupta, Narendra Agrawal, Shobha Broor, M Mahapatra, Renu Saxena

  Mediterranean journal of hematology and infectious diseases. 01/2011; 3(1):e2011039.

  Managing hematological disorders in a tropical country presents several unique diagnostic and management problems. Apart from the disease process, we need to be aware of infections that canManaging hematological disorders in a tropical country presents several unique diagnostic and management problems. Apart from the disease process, we need to be aware of infections that can exacerbate or mimic serious hematological problems. We present here a series of five patients with pre-existing hematological diseases who were infected by dengue virus. These cases highlight the need to keep a strong suspicion of common endemic diseases in tropical countries before considering extensive workup for the basic hematological disease. There was no mortality and all patients recovered without any significant impact on their pre-existing hematological condition inspite of their low baseline blood counts. There was no excessive bleeding, prolonged stay in the hospital or relapse of underlying hematological disease in these patients and the only major concern was the increased anxiety among both the patient and treating physician regarding the relapse/progression of pre-existing hematological disease.

• Acute lymphoblastic leukemia presenting as non-oliguric renal failure and hypertension.

  Authors: Nitin Gupta, Sanjeev Kumar Gupta, Shyam Rathi, Sanjeev Kumar Sharma, Manoranjan Mahapatra, Tulika Seth, Pravas Mishra, Renu Saxena

  Leukemia research. 07/2010; 34(7):e150-1.

• Extramedullary haematopoiesis in lymph node in a patient of T cell leukemia.

  Authors: Nitin Gupta, Sanjeev Kumar Gupta, Ayushi Jain, Manoranjan Mahapatra, Haraprasad Pati, Chitra Sarkar

  European journal of haematology. 12/2009;