Su Jin Lim

Sungkyunkwan University, Sŏul, Seoul, South Korea

Are you Su Jin Lim?

Claim your profile

Publications (26)48.25 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We studied the relative roles of Duox2-derived reactive oxygen species (ROS) in host defense against influenza A virus (IAV) infection in normal human nasal epithelial (NHNE) cells and mouse nasal mucosa. We found that Duox2 primarily generated ROS rapidly after IAV infection in NHNE cells, and that knockdown of Duox2 aggravated IAV infection. In addition, Duox2-derived ROS enhancement significantly suppressed IAV infection in nasal epithelium. In particular, Duox2-derived ROS were required for the induction of retinoic acid-inducible gene 1 (RIG-I), and melanoma differentiation-associated protein 5 (MDA5) transcription. Following intranasal IAV inoculation into mice, viral infection was significantly aggravated from 3 days post-infection (dpi) in the nasal mucosa and the IAV viral titer was highest at 7 dpi. Both RIG-I and MDA5 mRNA levels increased dominantly in mouse nasal mucosa from 3 dpi; consistent with this, RIG-I and MDA5 proteins were also induced after IAV infection. RIG-I and MDA5 mRNA levels were induced to a lower extent in the nasal mucosa of the mice which were inoculated Duox2 shRNA and the IAV viral titer was significantly higher in nasal lavage. Taken together, Duox2-derived ROS are necessary for the innate immune response and trigger the induction of RIG-I and MDA5 to resist IAV infection in human nasal epithelium and mouse nasal mucosa.
    American Journal of Respiratory Cell and Molecular Biology 03/2015; DOI:10.1165/rcmb.2014-0334OC · 4.11 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A bubble merged from two parent bubbles with different size tends to be placed closer to the larger parent. This phenomenon is known as the coalescence preference. Here we demonstrate that the coalescence preference can be blocked inside a densely packed cluster of bubbles. We utilized high-speed high-resolution X-ray microscopy to clearly visualize individual coalescence events inside densely packed microbubbles with a local packing fraction of ~40%. The surface energy release theory predicts an exponent of 5 in a relation between the relative coalescence position and the parent size ratio, whereas our observation for coalescence in densely packed microbubbles shows a different exponent of 2. We believe that this result would be important to understand the reality of coalescence dynamics in a variety of packing situations of soft matter.
    Scientific Reports 01/2015; 5:7739. DOI:10.1038/srep07739 · 5.08 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the effectiveness of sulodexide for the treatment of hard exudates (HE) in non-proliferative diabetic retinopathy (NPDR).
    Albrecht von Graæes Archiv für Ophthalmologie 08/2014; DOI:10.1007/s00417-014-2746-8 · 2.33 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Case study A woman aged 62 years presented with chronic throat pain on the right tonsillar area that had started approximately 2 years earlier. During the 2 years, she visited several local clinics, including internal medicine, family medicine and otolaryngology clinics, and underwent various tests, including esophagogastroduodenoscopy. However, there was no improvement in the symptom and the cause was not identified. She was referred by her family doctor to our hospital for further evaluation and proper management. The pain was characterised by an intermittent, needle-like, piercing pain on the right tonsillar area and could be worsened by swallowing and neck rotation. There was no history of any medical problems, trauma or surgery. Careful visual examination of the oral cavity and oropharynx revealed no particular abnormalities. During pharyngeal palpation, a hard mass was felt on the right tonsillar area and she complained of severe pain when turning her neck to the right. A radiographic study (reverse Towne's view) was performed (Figure 1).
    Australian family physician 07/2014; 43(7):454-6. · 0.67 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mitochondrial dysfunction reflects a lifelong cumulative burden of cellular damage, and a decrease in mitochondrial DNA (mtDNA) copy number is associated with oxidative stress and chronic inflammation. The goal of this study was to assess whether mitochondrial dysfunction and a decrease in mtDNA copy number is a common feature of patients with obstructive sleep apnea syndrome (OSA). We compared mtDNA copy number between 20 healthy volunteers and 20 patients with OSA and investigated whether a significant attenuation of mtDNA copy number was observed in genomic DNA isolated from whole blood of OSA patients. Our observations lead to the hypothesis that mtDNA copy number is lower in whole blood DNA of OSA subjects and might be related to OSA severity, reflecting excessive oxidative stress in patients with OSA.
    Antioxidants and Redox Signaling 06/2014; 21(9). DOI:10.1089/ars.2014.5955 · 7.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objectives This study aimed to evaluate the hypothesis that relief of nasal obstruction in subjects with obstructive sleep apnea (OSA) would lead to reduce OSA severity and to discuss the available evidence on the clinical efficacy of nasal surgery as a treatment modality for OSA. Study Design Twenty-five subjects who had reduced patency of nasal cavity and narrowing of retroglossal or retropalatal airways were diagnosed with OSA and underwent nasal surgery, such as septoplasty or turbinoplasty to correct nasal pathologies. The effect of the surgery on nasal patency was quantified by measuring minimal cross-sectional area (MCA) using acoustic rhinometry. The watch-PAT-derived respiratory disturbance index (RDI), apnea and hypopnea index (AHI), lowest oxygen saturation, and valid sleep time were measured before and after nasal surgery. Results The present study shows that the AHI and RDI decreased significantly and the lowest oxygen saturation and valid sleep time rose after nasal surgery in 25 OSA subjects. In addition, a reduction in subjective symptoms was observed in subjects and mean MCA increased after nasal surgery. Fourteen subjects were classified as responders and 11 subjects as non-responders. Responders showed considerable improvement of their subjective symptoms and the AHI and RDI were significantly lower after surgery. We found that the changes between pre- and post-operative AHI and RDI values were minimal in 11 non-responders. However, daytime somnolence and REM sleep time improved after nasal surgery in non-responders. Conclusions Our study provides evidence that the surgical treatment of nasal pathology improves nasal airway patency and reduces OSA severity in 56% subjects. Furthermore, correction of nasal pathology appears to result in improved sleep quality in both responder and non-responders OSA subjects.
    PLoS ONE 06/2014; 9(6):e98765. DOI:10.1371/journal.pone.0098765 · 3.53 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Angioleiomyoma is a benign myogenic tumor that may develop wherever smooth muscle is present. It occurs commonly in the uterus, skin, and gastrointestinal tract and is rare within the nasal cavity, but only three of 24 reported cases of sinonasal leiomyoma may have originated from the nasal septum. Treatment of choice for these neoplasms is surgical excision. We present one case of nasal septal angioleiomyoma arising from the nasal septum with symptoms of nasal obstruction and epistaxis, which were successfully removed by endoscopic surgery.
    01/2014; 57(5):337. DOI:10.3342/kjorl-hns.2014.57.5.337
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to assess the accuracy and clinical efficacy of a wrist-worn device that is based on peripheral arterial tonometry (watch-PAT) to evaluate the surgical results of obstructive sleep apnea (OSA) syndrome subjects. Thirty-five subjects who were diagnosed with OSA and underwent sleep surgeries such as septoplasty, tonsillectomy, or uvuloplasty to correct their airway collapse, participated in this study; the watch-PAT-derived respiratory disturbance index (RDI), apnea and hypopnea index (AHI), lowest oxygen saturation, and valid sleep time were measured after the sleep surgery. The present study showed that RDI (32.8 ± 10.7 vs 14.8 ± 7.5), AHI (30.3 ± 8.6 vs 13.4 ± 8.2 events/h), lowest oxygen saturation (78.2% ± 8.4% vs 90.5% ± 7.1%), and valid sleep time (329.1 ± 47.2 min and a postoperative value of 389.1 ± 50.1 min) recovered to within a normal range after surgery in 28 subjects. In addition, good agreement was found between watch-PAT-derived factors and visual analogue scales for changes in subjective symptoms, such as snoring, apnea, and daytime somnolence. Seven of the 35 subjects showed no improvement for their subjective symptoms and complained of snoring and apnea after surgery. We found that the RDI and AHI of those 7 subjects were not reduced, and the changes between pre- and postoperative values which were measured with watch-PAT were minimal. Their postoperative lowest oxygen saturation and valid sleep time were not elevated per the watch-PAT. The results support a strong correlation between the findings from watch-PAT and improved symptoms after surgical correction of an airway collapse. Our study provides evidence that the factors measured by the watch-PAT might be reliable indicators of symptomatic changes in OSA subjects after sleep surgery and also shows that the watch-PAT is a highly sensitive portable device for estimating treatment results in OSA. Park CY; Hong JH; Lee JH; Lee KE; Cho HS; Lim SL; Kwak JW; Kim KS; Kim HJ. Clinical usefulness of watch-PAT for assessing the surgical results of obstructive sleep apnea syndrome. J Clin Sleep Med 2014;10(1):43-47.
    Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine 01/2014; 10(1):43-7. DOI:10.5664/jcsm.3356 · 2.83 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Purpose: To investigate the prevalence of Toxoplasma gondii and Toxocara canis in patients with uveitis. Methods: Patients with uveitis were examined. Serum antibodies to T. gondii and T. canis were tested by using the enzyme-linked immunosorbent assay. Polymerase chain reaction (PCR) was done using blood and aqueous humor (AH). Results: Ninety-eight patients were enrolled. Mean age was 43.5 ± 13.2 years. Six patients were seropositive for T. gondii with the following pattern: anterior uveitis, 1; posterior uveitis with retinitis, 2; pan uveitis, 2. One patient had a positive PCR result for T. gondii in AH, who showed panuveitis. Twenty-three patients were positive to serum IgG for T. canis with the following clinical manifestation: granuloma, 6; pigmented scar, 3; vitritis, 6-but none were PCR positive. Conclusions: T. gondii and T. canis are still important causes of uveitis. Ocular toxocariasis is not an uncommon cause of uveitis, even in adults.
    Ocular immunology and inflammation 10/2013; 22(5). DOI:10.3109/09273948.2013.839798 · 1.44 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: PURPOSE: The aim of this study was to perform the detection of folate receptor (FR)-positive tumors with a bimodal imaging contrast agent, a perfluorocarbon (PFC)/rhodamine nanoemulsion, providing both (19)F-based magnetic resonance imaging (MRI) and fluorescence imaging capabilities. PROCEDURES: The PFC/rhodamine nanoemulsion was further infused with phospholipid-anchored folate to improve the ability to target FR-expressing tumors. The preferential accumulation of the FR-targeted bimodal nanoemulsion in FR-positive tumor sites was monitored by both (19)F-MRI and optical imaging. RESULTS: The FR-targeted PFC nanoemulsion had no significant effect on cell viability, and the size and fluorescence signal of PFC nanoemulsion were very stable. These nanoprobes were successfully delivered into FR-positive tumor xenograft models and showed significantly enhanced signal intensities of (19)F-MRI and fluorescence imaging in the tumor area. CONCLUSIONS: The folate-PFC/rhodamine nanoemulsion has a great potential to serve as a useful optical and (19)F-MRI agent for the diagnosis and targeting of FR-positive tumor.
    Molecular imaging and biology: MIB: the official publication of the Academy of Molecular Imaging 03/2013; 15(4). DOI:10.1007/s11307-013-0622-2 · 2.87 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to evaluate the non-dissected anatomic structures and abnormal computed tomographic findings that contribute to the recurrence of chronic rhinosinusitis (CRS) or the trail of revision endoscopic sinus surgery (ESS).
    01/2013; 56(12):764. DOI:10.3342/kjorl-hns.2013.56.12.764
  • [Show abstract] [Hide abstract]
    ABSTRACT: Arachnoid cyst develops due to cerebrospinal fluid increase in the subarachnoid space and is mostly located in the middle cranial fossa, which may be associated with non-specific symptoms such as headache, unsteadiness and ataxia. However, it rarely occurs in the posterior cranial fossa and is mostly asymptomatic. When symptoms do develop, they are usually headache and psychomotor retardation, which make diagnosis very difficult. Diagnosis is generally made through magnetic resonance imaging and surgical treatment is indicated for cases where there are displacement and compression of its surrounding neurovascular component, and aggravation of symptoms. We present a case of unilateral sudden hearing loss possibly developing from an arachnoid cyst in the posterior cranial fossa with a review of literatures.
    01/2013; 56(12):781. DOI:10.3342/kjorl-hns.2013.56.12.781
  • [Show abstract] [Hide abstract]
    ABSTRACT: To report a case of globe perforation and linear retinal tear after periocular acupuncture therapy which resulted in persistent temporal field defect with normal retinal function evidenced by multifocal electroretinogram (MERG).
    Journal of the Korean Ophthalmological Society 01/2013; 54(9):1475. DOI:10.3341/jkos.2013.54.9.1475
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.
    The Korean Journal of Parasitology 09/2012; 50(3):229-31. DOI:10.3347/kjp.2012.50.3.229 · 0.97 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: PURPOSE: To evaluate the efficacy of vitrectomy including internal limiting membrane (ILM) peeling without gas tamponade for myopic foveoschisis (MF). METHOD: In this retrospective study, 15 eyes of 13 consecutive patients with MF underwent pars plana vitrectomy and ILM peeling without gas tamponade. The main outcomes were measured using best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography (OCT). RESULT: The mean refractive error was -11.0 ± 8.2 diopters and mean axial length was 30.8 ± 2.6 mm. The mean BCVA increased from 0.78 ± 0.53 to 0.61 ± 0.75 logMAR unit (p = 0.05), and the mean CMT decreased from 405 ± 143 μm to 255 ± 47 μm (p = 0.002) during a follow-up of 11.8 months. OCT showed a complete resolution of the MF, with foveal reattachment in all eyes. Full-thickness macular hole developed in two eyes during follow-up. CONCLUSION: ILM peeling without gas tamponade results in favorable anatomical and visual outcomes.
    Albrecht von Graæes Archiv für Ophthalmologie 03/2012; 250(11). DOI:10.1007/s00417-012-1983-y · 2.33 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study compared outcomes in children with acute leukemia who underwent transplantations with umbilical cord blood (UCB), bone marrow, or peripheral blood stem cells from a human leukocyte antigen (HLA)-matched related donor (MRD) or an unrelated donor (URD). This retrospective study included consecutive acute leukemia patients who underwent their first allogeneic hematopoietic stem cell transplantation (HSCT) at Samsung Medical Center between 2005 and 2010. Patients received stem cells from MRD (n=33), URD (n=46), or UCB (n=41). Neutrophil and platelet recovery were significantly longer after HSCT with UCB than with MRD or URD (P<0.01 for both). In multivariate analysis using the MRD group as a reference, the URD group had a significantly higher risk of grade III to IV acute graft-versus-host disease (GVHD; relative risk [RR], 15.2; 95% confidence interval [CI], 1.2 to 186.2; P=0.03) and extensive chronic GVHD (RR, 6.9; 95% CI, 1.9 to 25.2; P<0.01). For all 3 donor types, 5-year event-free survival (EFS) and overall survival were similar. Extensive chronic GVHD was associated with fewer relapses (RR, 0.1; 95% CI, 0.04 to 0.6; P<0.01). Multivariate analysis showed that lower EFS was associated with advanced disease at transplantation (RR, 3.2; 95% CI, 1.3 to 7.8; P<0.01) and total body irradiation (RR, 2.1; 95% CI, 1.0 to 4.3; P=0.04). Survival after UCB transplantation was similar to survival after MRD and URD transplantation. For patients lacking an HLA matched donor, the use of UCB is a suitable alternative.
    Korean Journal of Pediatrics 03/2012; 55(3):93-9. DOI:10.3345/kjp.2012.55.3.93
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy. We examined 35 patients (27 men and 8 women) diagnosed with IC-GCTs between August 2004 and April 2008 and received risk-adapted carboplatin-based chemotherapy at the Samsung Medical Center. Patients were divided into either low-risk (LR) or high-risk (HR) groups and a retrospective analysis was performed using information from the medical records. Although hematological complications were common, hearing difficulties or grade 3 or 4 creatinine level elevation were not observed in patients who underwent carboplatin-based chemotherapy. The frequency of febrile neutropenia did not differ between the risk groups. The overall survival was 100% and event-free survival (EFS) was 95.7%. The EFS rate was 100% in the LR group and 90% in the HR group, respectively. Despite their common occurrence in high-risk patients, no lethal hematological complications were associated with carboplatin-based treatment. The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs.
    Korean Journal of Pediatrics 03/2011; 54(3):128-32. DOI:10.3345/kjp.2011.54.3.128
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The risk of invasive fungal infection is greater for allogeneic hematopoietic stem cell transplantation (HSCT) than for autologous transplantation. Therefore, many transplantation centers use antifungal prophylaxis for allogeneic HSCT, however, there exists no standard guidelines or consensus regarding autologous HSCT. A prospective double-blind randomized study was conducted in autologous HSCT recipients who were divided into prophylaxis and empirical treatment groups, and we investigated the efficacy of itraconazole prophylaxis in pediatric autologous HSCT. Total 87 autologous HSCT episodes in 55 children with high-risk solid tumors were studied. No invasive fungal infections occurred in either group. However, patients in the prophylaxis group had a significantly shorter duration of fever (p < 0.05) and received antibacterial treatment of shorter duration (p < 0.05) with fewer numbers of antibiotics (p < 0.05 for the use of second line antibiotics) than those in the empirical group. No significant additional adverse events were found with itraconazole prophylaxis. Although beneficial effects such as a shorter duration of fever and reduced need for antibiotic use were observed in the prophylaxis group, the results were not sufficient to draw a definite recommendation about the routine use of antifungal prophylaxis in pediatric autologous HSCT recipients with high-risk solid tumors (Trial registration: NCT00336531).
    Yonsei medical journal 03/2011; 52(2):293-300. DOI:10.3349/ymj.2011.52.2.293 · 1.26 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: An abstract is unavailable. This article is available as HTML full text and PDF.
    Retina (Philadelphia, Pa.) 11/2010; DOI:10.1097/IAE.0b013e3181fcbf32 · 3.18 Impact Factor
  • Article: Reply.
    Oh Woong Kwon, Su Jin Lim, Mi In Roh
    Retina (Philadelphia, Pa.) 09/2010; 30(8):1323. DOI:10.1097/IAE.0b013e3181e445c6 · 3.18 Impact Factor

Publication Stats

119 Citations
48.25 Total Impact Points

Institutions

  • 2008–2015
    • Sungkyunkwan University
      • • School of Advanced Materials Science and Engineering (AMSE)
      • • Department of Pediatrics
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2014
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
    • Chung-Ang University
      Sŏul, Seoul, South Korea
  • 2013
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2009–2013
    • Kim's Eye Hospital
      Sŏul, Seoul, South Korea
  • 2012
    • Gangneung Yeongdong College
      Gangneung, Gangwon-do, South Korea
  • 2011
    • Samsung Medical Center
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
  • 2010
    • Catholic University of Korea
      • Department of Anesthesiology and Pain Medicine
      Sŏul, Seoul, South Korea
    • Kyung Hee University
      Sŏul, Seoul, South Korea