Hiroshi Endo

Publications (2)3.81 Total impact

• Article: Clinical course of patients with aplastic anemia or myelodysplastic syndrome associated with persistent neutropenia.

  Shinichi Kako, Hideki Nakasone, Hiroshi Endo, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako, Misato Kikuchi, Shun-ichi Kimura, Shinya Okuda, Rie Yamazaki, Kumi Oshima, Aki Tanihara, Junji Nishida, Kensuke Usuki, Yoshinobu Kanda
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  ABSTRACT: Patients with aplastic anemia (AA) or myelodysplastic syndrome (MDS) often have persistent severe neutropenia and are susceptible to infectious complications. We retrospectively reviewed the clinical course of patients with AA or MDS who had neutropenia (neutrophil count < 500/µl) for more than 25 days. A total of 46 patients, 11 with AA and 35 with MDS, were included. Twenty-three patients had infectious events (IE), and the cumulative incidence of IE was 30% at 6 months and 51% at 1 year. The cumulative incidence of IE was 67% at 1 year in 30 patients who experienced very severe neutropenia of less than 200/µl. Overall survival in all patients was 76% at 6 months and 65% at 1 year. In a multivariate analysis, male sex, underlying diseases, and a neutrophil count of less than 200/µl as a time-dependent covariate significantly affected IE. In analyses that excluded patients with AA, male sex was the only factor. In conclusion, severe neutropenia was significantly associated with IE in patients with AA or MDS, and IE might be lethal. When we only considered patients with MDS, the neutrophil count alone could not be used to predict the prognosis.
  Hematological Oncology 06/2011; 30(2):82-8. · 2.47 Impact Factor
• Article: Diabetes mellitus is associated with high early-mortality and poor prognosis in patients with autoimmune hemolytic anemia.

  Hideki Nakasone, Shinichi Kako, Hiroshi Endo, Ayumu Ito, Miki Sato, Kiriko Terasako, Shinya Okuda, Yukie Tanaka, Rie Yamazaki, Kumi Oshima, Aki Tanihara, Michiko Kida, Takakazu Higuchi, Koji Izutsu, Junji Nishida, Akio Urabe, Kensuke Usuki, Yoshinobu Kanda
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  ABSTRACT: The incidence of autoimmune hemolytic anemia (AIHA) is highest among the elderly, and thus it is frequently associated with co-morbidities such as diabetes mellitus (DM). However, there have been few reports on the impact of these co-morbidities on survival in patients with AIHA. Therefore, we retrospectively reviewed the records of 53 consecutive AIHA patients and assessed the impact of DM on survival. Eighteen of the 53 patients had DM. The estimated 4-year overall survival (4y-OS) for all patients was 84.9%. Infection was the most frequent cause of death, and fatal infections were exclusively observed in patients with DM. The deaths in DM patients occurred frequently within 1 year, to give significantly poor survival (4y-OS; 69.3% versus 93.6%, P=0.0064). The presence of DM was identified as the only significant risk factor for survival. A large prospective investigation is warranted to assess the impact of co-morbidities on survival in patients with AIHA.
  Hematology (Amsterdam, Netherlands) 12/2009; 14(6):361-5. · 1.33 Impact Factor