Sheijy S V Mogami

Publications (2)4.81 Total impact

• Source

  Available from: André Luis Souza dos Santos

  Article: Multiple effects of amprenavir against Candida albicans.

  Lys A Braga-Silva, Sheijy S V Mogami, Roberta S Valle, Ignácio D Silva-Neto, André L S Santos
  [show abstract] [hide abstract]
  ABSTRACT: Secreted aspartyl peptidases (Saps) are virulence attributes produced by Candida albicans that participate in multiple aspects of the fungal biology and pathogenesis. In the present paper, we have shown that amprenavir, a peptidase inhibitor used in HIV chemotherapy, inhibited Sap2 and growth of C. albicans and also promoted ultrastructural alterations. Esterase activity, sterol content, biofilm formation and the expression of surface mannose- and sialic acid-rich glycoconjugates were also reduced by amprenavir.
  FEMS Yeast Research 03/2010; 10(2):221-4. · 2.40 Impact Factor
• Article: Multiple effects of amprenavir against Candida albicans

  Lys A. Braga-Silva, Sheijy S.V. Mogami, Roberta S. Valle, Ignácio D. Silva-Neto, André L.S. Santos
  [show abstract] [hide abstract]
  ABSTRACT: Secreted aspartyl peptidases (Saps) are virulence attributes produced by Candida albicans that participate in multiple aspects of the fungal biology and pathogenesis. In the present paper, we have shown that amprenavir, a peptidase inhibitor used in HIV chemotherapy, inhibited Sap2 and growth of C. albicans and also promoted ultrastructural alterations. Esterase activity, sterol content, biofilm formation and the expression of surface mannose- and sialic acid-rich glycoconjugates were also reduced by amprenavir.
  FEMS Yeast Research 02/2010; 10(2):221 - 224. · 2.40 Impact Factor