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Nagahito Saito,
Katsuhiro Higashiura,
Kazunori Ehata,
Shinji Kurosawa,
Kenta Honma,
Masayuki Abe,
Akihiko Kimura, Mio Suzuki,
Shigeo Nakamura,
Hiroshi Shiku,
Hong Kean Ooi
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ABSTRACT: Deletion of the long arm of chromosome 20 (del 20q) has been observed in patients with myelodysplastic syndrome (MDS) or myeloid malignancies. We experienced an MDS female case of del 20q accompanied by clusters of plasmacytic cells in bone marrow. Her bone marrow cells showed morphological abnormalities in three lineages and the chromosomal abnormality of 46, XX, del (20) (q11.2q13.3). Although the percentage of plasma cells was low in free cells, such cells showed nuclear abnormalities. In bone marrow clots, we also observed clusters of anti-CD38 and anti-CD138 antibody-positive cells. According to the FAB or WHO classification, the diagnosis was unclear. Therefore, we were obliged to term this case as MDS with plasma cell dysplasia. This patient was considered to be a rare case of MDS related to abnormalities in myeloid and B-lymphoid cells.
Journal of Clinical and Experimental Hematopathology 01/2011; 51(2):141-5.
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Masayoshi Ono,
Shunsuke Ohnishi,
Reizo Onishi,
Shojiro Takahashi,
Yoshimitsu Kobayashi, Mio Suzuki,
Kimitoshi Kubo,
Masayoshi Dazai,
Junji Yamamoto,
Hisashi Oda,
Kenji Tada,
Tatsuro Takahashi,
Takuto Miyagishima
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ABSTRACT: A 70-year-old male, who had undergone resection of gastric malignant lymphoma in 1992, presented with cervical lymph node swelling in January 2008. Pathological examination of the lymph node biopsy demonstrated recurrence of malignant lymphoma, and he was treated with the R-CHOP regimen. Although he did not develop fever during the first through third course of R-CHOP, from the fourth course, he repeatedly demonstrated fever over 38°C for about one week after each course of chemotherapy, despite the absence of neutropenia. Helicobacter cinaedi infection was confirmed by blood culture each time. Although it is difficult to diagnose Helicobacter cinaedi infection by the standard culture method, increased numbers of recent reports especially in immunocompromised patients have emphasized the importance of diagnosing Helicobacter cinaedi infection.
[Rinshō ketsueki] The Japanese journal of clinical hematology 12/2010; 51(12):1781-5.
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Takahide SASAKI,
Shunsuke OHNISHI,
Reizo ONISHI,
Ryou TAKEMURA,
Yoshimitsu KOBAYASHI, Mio SUZUKI,
Masayoshi DAZAI,
Tamotsu HATA,
Junji YAMAMOTO,
Hisashi ODA,
Tatsuro TAKAHASHI,
Kazuhiro OGASAWARA,
Takuto MIYAGISHIMA
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ABSTRACT: A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of vascular endothelial growth factor (VEGF), and was diagnosed with POEMS syndrome. Following administration of methyl prednisolone, ascites immediately decreased and her performance status improved; however, about 18 months later, renal failure occurred, and she died despite increased steroid dosage. Lymph node swelling is often found in POEMS syndrome; however, its histological appearance is not well known, and it is very rare to be concomitant with malignant lymphoma. Therefore, it is important to perform a lymph node biopsy and investigate it in relation with VEGF.
[Rinshō ketsueki] The Japanese journal of clinical hematology 11/2009; 50(11):1621-5.
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ABSTRACT: A 60-year-old man was referred to our hospital since his stool examination was positive for occult blood. Colonoscopy showed a tumor of Bauhin's valve and terminal ileum. Biopsy of the tumor was performed and pathological examination revealed adenocarcinoma. No other lesions were detected by gastroduodenoscopy and double-balloon enteroscopy. CT also showed multiple liver metastases. Ileocecal resection was performed because of severe stenosis of the terminal ileum. Histopathological examination revealed moderately-differentiated adenocarcinoma of Bauhin's valve and the terminal ileum, and no adenocarcinoma was found in the cecum and ascending colon. He was diagnosed with primary adenocarcinoma of the ileum with multiple liver metastases. Chemotherapy with mFOLFOX6 was performed after surgical resection. After 5 courses of chemotherapy, abdominal CT showed marked regression of the liver metastases, and tumor marker (CA19-9) was normalized from 1,100 U/mL to 36 U/mL. Effectiveness of mFOLFOX6 for primary adenocarcinoma of small intestine is suggested.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(11):1927-9.
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Mitsuteru Natsuizaka,
Mineo Kudo, Mio Suzuki,
Masatoshi Takano,
Masako Tsuyuguchi,
Naoyuki Kawamura,
Shinsuke Noguchi,
Akinori Wada,
Masanobu Nakata,
Masahiro Ogasawara,
Yoshio Kiyama,
Masahiro Asaka,
Masaharu Kasai
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ABSTRACT: We describe a case of diffuse large B-cell lymphoma with massive portal vein tumor thrombosis in a patient with alcoholic cirrhosis. The tumor was detected only in the intrahepatic portal vein and the spermatic cord by FDG-PET/CT. Percutaneous liver biopsy and orchiectomy were performed and histological examination revealed diffuse large B-cell lymphoma. The tumor showed complete response after six courses of the combination chemotherapy. Portal vein tumor thrombosis of malignant lymphoma is extremely rare; moreover, it is possible that this is the first case of malignant lymphoma originating from the spermatic cord producing portal vein tumor thrombosis.
Internal Medicine 02/2009; 48(10):805-8. · 0.94 Impact Factor
