Claudia C. Wagner

National University of Central Buenos Aires, Tandil, Provincia de Buenos Aires, Argentina

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Publications (17)23.47 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The FTIR and FT-Raman spectra of the gallium(III) complexes of 8-hydroxyquinoline (oxine) and 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), were recorded and briefly discussed by comparison with the spectra of the uncoordinated ligands and with some related species.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 05/2011; 79(5):1762-5. · 1.98 Impact Factor
  • Claudia C Wagner, Enrique J Baran
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    ABSTRACT: The infrared and Raman spectra of Na[FeEDTA(H(2)O)]x2H(2)O and Na(4)[(FeEDTA)(2)O]x3H(2)O (EDTA=tetra anion of ethylenediaminetetraacetic acid), two complexes proposed as adequate for iron supplementation, were recorded and analyzed in relation to its structural peculiarities. Some comparisons between the recorded spectra are also presented, and the characteristics of the carboxylate motions as well as those of the metal-to-ligand vibrations are discussed in detail.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 02/2010; 75(2):807-10. · 1.98 Impact Factor
  • Claudia C Wagner, Enrique J Baran
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    ABSTRACT: The infrared and Raman spectra of the bis-chelated Zn(II) complexes of the amino acids glycine, alanine, valine, leucine, isoleucine and phenylalanine were recorded and analyzed in relation to its structural peculiarities. Some comparisons between the recorded spectra are also presented and the characteristics of the carboxylate motions as well as those of the metal-to-ligand vibrations are discussed in detail.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 01/2009; 72(5):936-40. · 1.98 Impact Factor
  • Claudia C. Wagner, Enrique J. Baran
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    ABSTRACT: Polaprezinc, the Zn(II) complex of the dipeptide carnosine (β-alanyl histidine) presents an interesting biological and pharmacological activity, specially as an anti-ulcer agent. The infrared and Raman spectra of this compound were recorded and briefly discussed. Some comparisons were made with related complexes and with free carnosine. The results confirm the coordination environment of the Zn(II) cation, constituted by the terminal amino N-atom, the deprotonated amide N-atom and one carboxylate oxygen of one dipeptide molecule and the N-atom of the imidazole moiety of a second carnosine molecule. Copyright © 2007 John Wiley & Sons, Ltd.
    Journal of Raman Spectroscopy 11/2007; 39(4):474 - 477. · 2.68 Impact Factor
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    ABSTRACT: The infrared and Raman spectra of 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) and that of its Cu(II) complex of stoichiometry [Cu(CQ)2] were recorded and briefly discussed. Some comparisons were made with related complexes. The interest of the investigated systems in relation to Alzheimer's disease is briefly commented. Copyright © 2006 John Wiley & Sons, Ltd.
    Journal of Raman Spectroscopy 11/2006; 38(4):373 - 376. · 2.68 Impact Factor
  • Claudia C. Wagner, Enrique J. Baran
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    ABSTRACT: The infrared and Raman spectra of lithium, zinc, calcium and magnesium complexes of L-pyroglutamic acid were recorded and are briefly discussed. For the first three compounds the spectral discussion is based on their known structural characteristics. Comparing the spectroscopic behaviour of the complexes and the free acid, some comments on the structural peculiarities of the magnesium compound could be advanced. The pharmacological interest of these complexes is also briefly discussed. Copyright © 2004 John Wiley & Sons, Ltd.
    Journal of Raman Spectroscopy 05/2004; 35(5):395 - 400. · 2.68 Impact Factor
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    ABSTRACT: The electrochemical properties and the stability of the CrIII complexes [Cr(pic)3]·H2O and [Cr(pic)2(OH)]2·5H2O (Hpic = pyridine-2-carboxylic acid = picolinic acid) were investigated in DMF solutions by cyclic voltammetry, and complemented by electronic spectroscopy. The electrochemical results indicate that both compounds undergo a one-electron reversible reduction process. The mononuclear species has a more accessible reduction potential than the binuclear one. In this last case, the observed one-electron process can be ascribed to a considerable stabilization of the mixed valence CrIII/CrII species. Both complexes were also characterized by infrared and Raman spectroscopy.Voltammetrische und spektrospische Untersuchung von Chrom(III)/Picolinat KomplexenDas elektrochemische Verhalten und die Stabilität der CrIII-Komplexe [Cr(pic)3]·H2O und [Cr(pic)2(OH)]2·5H2O (Hpic = Pyridin-2-Carboxyl-Säure = Picolin- Säure) wurde in DMF Lösung durch cyklische Voltammetrie untersucht und durch Elektronenspektroskopie ergänzt. Die elektrochemischen Ergebnisse zeigen, dass in beiden Verbindungen ein umkehrbarer Ein-Elektron-Reduktionsprozess stattfindet. Die mononukleare Spezies hat ein geringeres Reduktionspotential als die zweikernige. Der in diesem letzten Fall beobachtete Ein-Elektron-Prozess lässt sich durch eine beträchtliche Stabilisierung der gemischten-Valenz CrIII/CrII-Spezies erklären. Beide Komplexe wurden auch mittels Infrarot und Raman Spektroskopie charakterisiert.
    Zeitschrift für anorganische Chemie 05/2003; 629(6):1085 - 1090. · 1.16 Impact Factor
  • Enrique J. Baran, Claudia C. Wagner
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    ABSTRACT: The infrared and Raman spectra of silver saccharinate Ag(C7H4NO3S), were recorded and are briefly discussed on the basis of its structural characteristics and by comparison with the spectra of some related species. Copyright © 2001 John Wiley & Sons, Ltd.
    Journal of Raman Spectroscopy 11/2001; 32(12):1064 - 1066. · 2.68 Impact Factor
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    ABSTRACT: The crystal structure of [Tl2(sac)2(H2O)]n (sac = saccharinate anion) has been solved using single crystal X-ray diffraction. It crystallizes in the triclinic space group P 1 with Z = 2 and presents a polymeric structure formed by two saccharinate anions, one water molecule and two chemically different TlI cations, one 8-coordinate and the other 5-coordinate. Saccharinate shows an unprecedented coordination behavior as it acts as chelating ligand through its N and carbonyl O atoms with the N atom interacting simultaneously with both metal centers, and participation of sulphonyl oxygen atoms in bonding. The most important features of the IR spectrum of the complex are discussed on the basis of the structural peculiarities.Charakterisierung von Thallium(I) Saccharinat: eine neuartige Bindungsform des Saccharinat LigandenDie Kristallstruktur von [Tl2(sac)2(H2O)]n (sac = Anion des Saccharins) wurde röntgenographisch an Einkristallen bestimmt. Es kristallisiert in der triklinen Raumgruppe P 1 mit Z = 2 und zeigt eine polymere Struktur, welche aus zwei Saccharinat Anionen, einem Wasser-Molekül und zwei chemisch verschiedenen TlI-Kationen (eines mit der KZ = 8 und das andere mit der KZ = 5) besteht. Das Saccharinat zeigt eine neuartige Bindungsform, da es als Chelatligand über seine N- und O(carbonyl)-Atome fungiert, wobei das N-Atom gleichzeitig mit beiden Metallzentren in Wechselwirkung tritt, und auch die Sulphonyl-Sauerstoffatome an den Bindungen beteiligt sind. Die wichtigsten Aspekte des IR-Spektrums des Komplexes werden an Hand der Strukturbesonderheiten analysiert und besprochen.
    Zeitschrift für anorganische Chemie 01/2001; 627(1):85-89. · 1.16 Impact Factor
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    ABSTRACT: The crystal structure of [Pb(sac)2ophen(H2O)2] (sac = saccharinate anion; ophen = 1,10-phenanthroline) has been solved by single X-ray diffractometry. It crystallizes in the monoclinic space group C2/c with Z = 4. The PbII atom presents the coordination number eight with unusual coordination of the ligand atoms between square-antiprism and dodecahedron. The saccharinate anion acts as a bidentate ligand. The i. r. spectrum of the complex has been analyzed in detail and assigned on the basis of the structural peculiarities.Kristallstruktur und IR-Spektrum von Diaqua(o-Phenanthrolin)-bis(saccharinato)blei(II)Die Kristallstruktur von [Pb(sac)2ophen(H2O)2] (sac = Anion des Saccharins; ophen = 1,10-Phenanthrolin) wurde röntgenographisch an Einkristallen bestimmt. Es kristallisiert in der monoklinen Raumgruppe C2/c mit Z = 4. PbII hat die Koordinationszahl acht, mit einer ungewöhnlichen Ligand-Anordnung zwischen viereckigen-Antiprisma und Dodekaeder. Das Saccharinat-Anion fungiert als zweizähniger Ligand. Das IR-Spektrum wird eingehend analysiert und auf Grund der Strukturdaten zugeordnet.
    Zeitschrift für anorganische Chemie 03/2000; 626(3):701-705. · 1.16 Impact Factor
  • Claudia C. Wagner, Enrique J. Baran
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    ABSTRACT: The infrared and Raman spectra of a platinum complex of the antiinflammatory drug piroxicam (Pir) and dimethylsulfoxide (DMSO) of composition [PtCl2Pir(DMSO)] were recorded and briefly discussed on the basis of its structural characteristics. The metal-to-ligand vibrations are analyzed in detail.
    Spectroscopy Letters 11/1999; 32(6):953-961. · 0.67 Impact Factor
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    ABSTRACT: The synthesis and X-ray crystal and molecular structures of a new Li(I) complex of stoichiometry [Li(isoor)H2O]2, where isoor is the monoanion of 5-carboxyuracil (isoorotic acid), are reported. It crystallizes in the monoclinic P21/n space group with Z=2, and a five-fold bipyramidal coordination around the Li(I) was observed for the first time. The electronic, infrared and Raman spectra of the complex are briefly discussed. Its thermal behavior was investigated by means of thermal gravimetry (TG) and differential thermal analysis (DTA). Dissolution studies were also performed in order to test the pharmacological characteristics of the complex.
    Journal of Inorganic Biochemistry. 01/1999;
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    ABSTRACT: The infrared and Raman spectra of a series of tetrametagermanates of composition Ln2CuGe4O12 (with Ln=Eu–Lu and Y), containing a Ge4O128- ring, were recorded and assigned on the basis of their structural characteristics. Force constants and mean amplitudes of vibration for the terminal GeO2 groups were also estimated. © 1997 John Wiley & Sons, Ltd.
    Journal of Raman Spectroscopy 12/1997; 28:927-931. · 2.68 Impact Factor
  • Source
    Claudia C Wagner, María H Torre, Enrique J Baran
  • Claudia C Wagner, Enrique J Baran
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    ABSTRACT: Acta Farm. Bonaerense 21 (4): 287-90 (2002) Recibido el 13 de junio de 2002 Aceptado el 7 de septiembre de 2002 Trabajos originales KEY WORDS: Bis(L-methioninate)Cu(II), IR spectrum, Raman spectrum. PALABRAS CLAVE: Bis(L-metioninato)Cu(II), Espectro IR, Espectro Raman. SUMMARY. The infrared and Raman spectra of the tittle complex were recorded and briefly discussed on the basis of its structural characteristics. Some comparisons with related Cu(II)/amino acid complexes were made. RESUMEN. "Espectro Vibracional del Bis(L-metioninato)cobre(II)". Se registraron los espectros de infrarojo y Raman del complejo del título y se los discutió brevemente en base a sus carcaterísticas estructurales. Se hacen algunas comparaciones con otros complejos de Cu(II)/amino ácidos relacionados. INTRODUCTION Copper (II) complexes of simple amino acids are of great pharmacological interest and importance as much of them present a wide spectrum of effects, including anti-inflammatory, antiulcer, anticonvulsant and even antitumoral activity 1-4 . As part of a research project devoted to the characterization of copper complexes with re-cognized pharmacological activity, in the last ye-ars we have investigated the spectroscopic pro-perties of the copper (II) complexes with amino acids containing hydrophobic 5 , hydroxylic 6 and acidic 7 residues. Most recently, we have al-so investigated the structure and general physi-cochemical properties of some simple Cu(II)/di-peptide complexes 8,9 . As a continuation of the-se studies we have now prepared and investiga-ted the infrared and Raman spectra of bis(L-met-hioninato)copper(II). Methionine (Figure 1) is one of the nine es-sential amino acids needed by human beings and is the only essential amino acid containing sulfur in its structure. Its copper (II) complex showed some antiulcer activity as revealed by animal model studies 10 and has also found so-me interest in veterinary medicine, for copper supplementation 11,12 .
  • Source
    Claudia C Wagner, Enrique J Baran
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    ABSTRACT: Acta Farm. Bonaerense 23 (3): 339-42 (2004) Recibido el 17 de noviembre de 2003 Aceptado el 10 de abril de 2004 Trabajos originales KEY WORDS: Bis(L-tryptophanate)Cu(II), Electronic spectrum, IR spectrum, Magnetic Susceptibility, Raman spectrum. PALABRAS CLAVE: Bis(L-triptofanato)Cu(II), Espectro Electrónico, Espectro IR, Espectro Raman, Susceptibi-lidad Magnética. SUMMARY. A copper(II) complex of the amino acid L-tryptophan, of stroichiometry Cu(Trp) 2 , was ob-tained from aqueous solution. Its structural characteristics were deduced from the careful analysis of in-frared, Raman and electronic absorption spectra, complemented with magnetic susceptibility measure-ments in the temperature range between 2 and 300 K. The metal center presents a distorted octahedral CuN 2 O 4 environment with a trans arrangement of the amino acids in the equatorial plane, involving the terminal amino and carboxylate groups. The coordination sphere is complemented with two longer apical Cu-O bonds involving "free" O-carboxylato atoms of neighboring complex moieties. RESUMEN. "Comportamiento Espectroscópico y Magnético del Complejo de Cobre (II) con L-Triptofano". Un complejo de cobre (II) con el amino ácido L-triptofano, de estequiometría Cu(Trp) 2 , fue obtenido de solución acuosa. Sus características estructurales fueron deducidas en base a un pormenorizado análisis de sus espectros de infrarrojo, Raman y de absorción electrónica, complementado con medidas de susceptibilidad magnética en el intervalo de temperaturas entre 2 y 300 K. El centro metálico presenta un entorno CuN 2 O 4 octaédrico distorsio-nado con una disposición trans de los amino ácidos en el plano ecuatorial, involucrando los grupos amino y car-boxilato terminales. La esfera de coordinación se complementa con dos enlaces Cu-O axiales más largos, involu-crando átomos de oxígeno "libres" de grupos carboxilato de unidades complejas vecinas. INTRODUCTION As a continuation of our studies of the gen-eral physicochemical properties of copper com-plexes of amino acids with pharmacological ac-tivity 1-5 , we have now prepared and investigat-ed the spectroscopic (vibrational and electronic) and magnetic behaviour of the corresponding complex of L-tryptophan, with Cu(Trp) 2 stoi-chiometry. As known, this complex presents an interesting anti-inflammatory, antiulcer and anti-convulsant activity 6-9 .
  • Claudia C Wagner, Enrique J Baran
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    ABSTRACT: . The recently reported mixed metal glutamate complex of stoichiometry [CuMg(L-glu) 2 (H 2 O) 3 ].2H 2 O was obtained as microcrystalline powder from aqueous solution. Its structure was con-firmed by X-ray diffractometry. The infrared spectrum of the complex was recorded and briefly discussed in relation to its structural characteristics. Its magnetic behavior was investigated by magnetic susceptibil-ity measurements in the temperature range between 2 and 300 K, complemented with ESR (Q-and X-band) spectra. These measurements confirmed a certain magnetic interaction between the Cu(II) centers present in the polymeric structure of the compound. The study was completed with a series of dissolution tests, which confirmed the potential usefulness of this complex for metal supplementation in human and veterinary medicine. RESUMEN. "Propiedades Vibracionales y Magnéticas de un Complejo deCu/Mg con Glutamato". El complejo metálico mixto de glutamato recientemente descripto, de estequiometría [CuMg(L-glu) 2 (H 2 O) 3 ].2H 2 O, fue obte-nido en forma de polvo microcristalino de solución acuosa. Su estructua fue confirmada por difracción de rayos X. El espectro de infrarrojo del complejo fue registrado y discutido brevemente en base a sus peculiaridades es-tructurales. Su comportamiento magnético se investigó a través de mediciones de susceptibilidad magnética en el intervalo de temperaturas entre 2 y 300 K, complementadas con espectros ESR (en bandas Q y X). Estas medidas confirmaron una cierta interacción entre los centros de Cu(II) presentes en la estructura polimérica del compues-to. El estudio se completó con una serie de ensayos de disolución, los que confirmaron la potencial utilidad de este complejo para la suplementación de metales en medicina humana y veterinaria. INTRODUCTION As a continuation of our studies devoted to the synthesis and characterization of new simple systems potentially useful for trace elements supplementation 1-9 , we have now investigated the recently reported mixed metal complex of glutamic acid, of composition [CuMg(L-Glu) 2 (H 2 O) 3 ].2H 2 O 10 . L-glutamic acid (L-H 2 Glu, Fig. 1) complexes are considered an ideal form for magnesium supplementation 11 , whereas copper (II) com-plexes of simple amino acids have been often used for copper supplementation and in other pharmacological applications 8,12-14 . Therefore, this new mixed cation complex seems to be sui-table for the simultaneous supplementation of both essential metal elements. In this paper we present the results of our investigation of its vi-brational and magnetic behaviour complemen-ted with some dissolution assays.

Publication Stats

34 Citations
23.47 Total Impact Points

Institutions

  • 1997–2011
    • National University of Central Buenos Aires
      • • Departamento de Ingeniería Química
      • • Facultad de Ingeniería
      Tandil, Provincia de Buenos Aires, Argentina
  • 1999–2001
    • National University of La Plata
      • • Facultad de Ciencias Exactas
      • • Centro de Química Inorgánica (CEQUINOR)
      La Plata, Provincia de Buenos Aires, Argentina