Rezene Fessehatsion

Publications (2)8.08 Total impact

• Article: Hashimoto's thyroiditis in a benign cystic teratoma of the ovary: case report and literature review.

  Isabella Lupi, Rezene Fessehatsion, Alessandra Manca, Paolo Cossu-Rocca, Enio Martino, Enrico Macchia
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  ABSTRACT: Ectopic thyroid tissue in ovarian teratoma or in struma ovarii appears to be histologically identical to the thyroid gland tissue and may virtually exhibit all the pathological patterns found in the thyroid gland. However, the concurrent lymphocytic infiltration of the thyroid gland, as found in Hashimoto's thyroiditis, and of the ectopic thyroid tissue is extremely rare. We describe the case of an 18-years old patient, in which a right ovarian 4 cm cyst has been found during pelvic ultrasound exam. The cyst was resected and microscopic examination of the mass revealed a mature cystic teratoma in which epidermal-like lining with skin adnexa, admixed with respiratory type epithelium, and areas of mature fatty, chondroid and dentigerous tissues were found. In a peripheral area of 0.7 cm  ×  0.5 cm, a prominent lymphocytic infiltrate surrounding thyroid follicles was identifiable. Thyroid function evaluation at different time points after surgery, revealed the development of mild hypothyroidism. Anti-TPO and anti-Tg autoantibodies were elevated, at fine needle aspiration biopsy a lymphocytic infiltrate, compatible with Hashimoto's thyroiditis, was present. We report here a rare case of Hashimoto's thyroiditis occurring both in the thyroid and in the ectopic thyroid tissue in the context of a benign cystic teratoma of the ovary.
  Gynecological Endocrinology 05/2011; 28(1):39-42. · 1.58 Impact Factor
• Article: Impact of lithium on efficacy of radioactive iodine therapy for Graves' disease: a cohort study on cure rate, time to cure, and frequency of increased serum thyroxine after antithyroid drug withdrawal.

  Fausto Bogazzi, Clara Giovannetti, Rezene Fessehatsion, Maria Laura Tanda, Alberto Campomori, Emanuele Compri, Giuseppe Rossi, Claudia Ceccarelli, Paolo Vitti, Aldo Pinchera, Luigi Bartalena, Enio Martino
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  ABSTRACT: Radioactive iodine (RAI) is a common therapy for hyperthyroidism due to Graves' disease. A small but significant proportion of patients have recurrence of hyperthyroidism after RAI therapy. Lithium might increase RAI effectiveness by increasing RAI retention in the thyroid. However, whether lithium favorably affects the long-term outcome of RAI therapy is still a matter of argument. The objective of the study was to compare the efficacy of RAI given with or without concomitant lithium treatment. This was a retrospective cohort study. The study was conducted at a tertiary university center. Patients: Six hundred fifty-one patients with newly diagnosed Graves' disease participated in the study. Two hundred ninety-eight patients were treated with RAI plus lithium (900 mg/d for 12 d) and 353 with RAI alone. Main Outcome Proportion of cured patients and time to achieve cure of hyperthyroidism during 1 yr of follow-up was measured. Patients treated with RAI plus lithium had a higher cure rate (91.0%) than those treated with RAI alone (85.0%, P = 0.030). In addition, patients treated with RAI plus lithium were cured more rapidly (median 60 d) than those treated with RAI alone (median 90 d, P = 0.000). Treatment with lithium prevented the serum free T(4) increase after methimazole withdrawal and RAI therapy. Side effects after RAI therapy occurred in a subset of patients and were mild, transient, and without differences in the two groups. Conclusions: RAI combined with lithium is safe and more effective than RAI alone in the cure of hyperthyroidism due to Graves' disease.
  The Journal of clinical endocrinology and metabolism 11/2009; 95(1):201-8. · 6.50 Impact Factor