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ABSTRACT: A temperature-responsive polymer poly{2-(dimethylamino)ethyl methacrylate-co-[cis-butenedioic anhydride-poly[(N-isopropylacrylamide)-co-(butyl methacrylate)]]} (PDMNIB) was synthesized by free radical polymerization. The polymer had a significant temperature-responsive behavior with a lower critical solution temperature (LCST) at 20 degrees C. Gel retardation assay showed that PDMNIB could efficiently interact with DNA. Dynamic light scattering (DLS) and zeta potential measurement indicated that the average sizes and the surface electric charges of the PDMNIB/DNA complexes could be changed by temperature. Due to the thermosensitive interaction between PDMNIB and DNA, the gene transfection efficiency of PDMNIB could be improved by temperature.
Macromolecular Bioscience 11/2009; 10(2):202-10. · 3.89 Impact Factor
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Lei Liu,
Xinxin Li,
Sen Hou,
Yonglai Xue,
Yang Yao, Yongzheng Ma,
Xizeng Feng,
Song He,
Yan Lu,
Yongmei Wang,
Xianshun Zeng
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ABSTRACT: Luminescent bifunctional core-shell nanoparticles were successfully constructed from block copolymer encapsulating Re(phen) complexes for simultaneous cell imaging and gene transfection in living cells.
Chemical Communications 11/2009; · 6.17 Impact Factor
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ABSTRACT: Fabrication of porous polymer films is important for its potential applications in industry and everyday life. In this study, a thermoresponsive polymer poly(N-isopropylacrylamide-co-butylmethacrylate) (PNIBMA) was introduced to fabricate porous films on the glass surface. PNIBMA can alter its structure with temperature and has a lower critical solution temperature (LCST) of about 20 °C. The porous film of PNIBMA was prepared by drying a drop of PNIBMA solution (in CHCl3) on a glass surface under a moist air flow. Atomic force microscope (AFM) images showed that the porous polymer film contained many layers of vacant spheres with diameters of about 1 μm. This unique surface characteristic endowed the porous film with higher hydrophobicity than a flat PNIBMA film made by direct coating. This study expanded the materials for porous films fabrication in the field of thermoreponsive polymers and should be of great potential in scientific researches and industry applications.
Colloids and Surfaces A: Physicochemical and Engineering Aspects.
